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View article: GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated EZH2 and TP53 at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses
GMP-like and MLP-like Subpopulations of Hematopoietic Stem and Progenitor Cells Harboring Mutated EZH2 and TP53 at Diagnosis Promote Acute Myeloid Leukemia Relapse: Data of Combined Molecular, Functional, and Genomic Single-Stem-Cell Analyses Open
Acute myeloid leukemia (AML) is associated with unfavorable patient outcomes primarily related to disease relapse. Since specific types of leukemic hematopoietic stem and progenitor cells (HSPCs) are suggested to contribute to AML propagat…
View article: Time-aligned hourglass gastrulation models in rabbit and mouse
Time-aligned hourglass gastrulation models in rabbit and mouse Open
The hourglass model describes the convergence of species within the same phylum to a similar body plan during development; however, the molecular mechanisms underlying this phenomenon in mammals remain poorly described. Here, we compare ra…
View article: Whole-Genome Amplification—Surveying Yield, Reproducibility, and Heterozygous Balance, Reported by STR-Targeting MIPs
Whole-Genome Amplification—Surveying Yield, Reproducibility, and Heterozygous Balance, Reported by STR-Targeting MIPs Open
Whole-genome amplification is a crucial first step in nearly all single-cell genomic analyses, with the following steps focused on its products. Bias and variance caused by the whole-genome amplification process add numerous challenges to …
View article: Short tandem repeat stutter model inferred from direct measurement of<i>in vitro</i>stutter noise
Short tandem repeat stutter model inferred from direct measurement of<i>in vitro</i>stutter noise Open
Short tandem repeats (STRs) are polymorphic genomic loci valuable for various applications such as research, diagnostics and forensics. However, their polymorphic nature also introduces noise during in vitro amplification, making them diff…
View article: Retrospective cell lineage reconstruction in Humans using short tandem repeats
Retrospective cell lineage reconstruction in Humans using short tandem repeats Open
Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin 1 . Recently, novel in vivo methods and technologies utilizing genome editing enabled important insights into the cell lineages of an…
View article: Comparison of seven single cell Whole Genome Amplification commercial kits using targeted sequencing
Comparison of seven single cell Whole Genome Amplification commercial kits using targeted sequencing Open
Advances in biochemical technologies have led to a boost in the field of single cell genomics. Observation of the genome at a single cell resolution is currently achieved by pre-amplification using whole genome amplification (WGA) techniqu…
View article: A generic, cost-effective, and scalable cell lineage analysis platform
A generic, cost-effective, and scalable cell lineage analysis platform Open
Advances in single-cell genomics enable commensurate improvements in methods for uncovering lineage relations among individual cells. Current sequencing-based methods for cell lineage analysis depend on low-resolution bulk analysis or rely…
View article: Short Tandem Repeat stutter_model_inferred from direct measurement of in vitro stutter noise
Short Tandem Repeat stutter_model_inferred from direct measurement of in vitro stutter noise Open
Short tandem repeats (STRs) are polymorphic genomic loci valuable for various applications such as research, diagnostics and forensics. However, their polymorphic nature also introduces noise during in vitro amplification, making them diff…