Ofrah Faust
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The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle Open
The Hsp90 molecular chaperone system is regulated by numerous co-chaperones that modulate its function. In Saccharomyces cerevisiae, most of these cofactors can be deleted without affecting viability. Of the three essential ones, only the …
View article: The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle
The essential co-chaperone Sgt1 regulates client dwell time in the Hsp90 chaperone cycle Open
SUMMARY The Hsp90 machinery is the most complex chaperone system in the eukaryotic cell. It is characterized by numerous co-chaperones that modulate the function of Hsp90. In S. cerevisiae , most of these cofactors can be deleted without a…
A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53 Open
SUMMARY J-domain proteins (JDPs) constitute a large family of molecular chaperones that bind a broad spectrum of substrates, targeting them to Hsp70, thus determining the specificity and activating the entire chaperone functional cycle. Th…
Hsp40s play complementary roles in the prevention of tau amyloid formation Open
The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as Alzheimer's disease. In the cell, however, tau aggregation can be prevented by a class of protei…
Author response: Hsp40s play complementary roles in the prevention of tau amyloid formation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The microtubule-associated pr…
Hsp40s display class-specific binding profiles, serving complementary roles in the prevention of tau amyloid formation Open
The microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles, forming insoluble, amyloid-type aggregates associated with neurodegenerative conditions, such as Alzheimer’s disease. Tau aggregation, however, can b…