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View article: Expression levels of the Band-7 protein FLOTILLIN modulate salt tolerance, growth and development in the moss <i>Physcomitrium patens</i>
Expression levels of the Band-7 protein FLOTILLIN modulate salt tolerance, growth and development in the moss <i>Physcomitrium patens</i> Open
The Band-7 proteins, known as FLOTILLINs (FLOT), are present at the plasma membranes of most land plants. They function in clathrin-independent endocytosis and contribute to nodule formation following symbiotic infections. This study revea…
Identification and characterization of <i>DICER‐LIKE</i> genes and their roles in <i>Marchantia polymorpha</i> development and salt stress response Open
SUMMARY DICER‐LIKE (DCL) proteins play a central role in plant small RNA (sRNA) biogenesis. The genome of the early land plant Marchantia polymorpha encodes four DCL proteins: MpDCL1a, MpDCL1b, MpDCL3, and MpDCL4. While MpDCL1a, MpDCL3 and…
Identification and characterization of <i>DICER-LIKE</i> genes and their roles in <i>Marchantia polymorpha</i> development and stress adaptation Open
DICER-LIKE (DCL) proteins have a central role in plant small RNA (sRNA) biogenesis. The Marchantia polymorpha genome encodes four DCL proteins: two DCL1 homologs, MpDCL1a and MpDCL1b, MpDCL3 and MpDCL4. While MpDCL1a, MpDCL3 and MpDCL4 sho…
<i>DICER‐LIKE1a</i> autoregulation based on intronic microRNA processing is required for stress adaptation in <i>Physcomitrium patens</i> Open
SUMMARY The Physcomitrium patens DICER‐LIKE1a ( PpDCL1a ) mRNA encoding the essential Dicer protein for microRNA (miRNA) biogenesis harbors an intronic miRNA (miR1047). An autoregulatory mechanism to control PpDCL1a abundance that is based…
Identification of Small RNAs During High Light Acclimation in Arabidopsis thaliana Open
The biological significance of non-coding RNAs (ncRNAs) has been firmly established to be important for the regulation of genes involved in stress acclimation. Light plays an important role for the growth of plants providing the energy for…
Expression of a human cDNA in moss results in spliced mRNAs and fragmentary protein isoforms Open
Production of biopharmaceuticals relies on the expression of mammalian cDNAs in host organisms. Here we show that the expression of a human cDNA in the moss Physcomitrella patens generates the expected full-length and four additional trans…
Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors Open
The human complement system is an important part of the immune system responsible for lysis and elimination of invading microorganisms and apoptotic body cells. Improper activation of the system due to deficiency, mutations, or autoantibod…
Critical Evaluation of Strategies for the Production of Blood Coagulation Factors in Plant-Based Systems Open
The use of plants as production platforms for pharmaceutical proteins has been on the rise for the past two decades. The first marketed plant-made pharmaceutical, taliglucerase alfa against Gaucher's disease produced in carrot cells by Pfi…