Oluwagbemiga A. Ojo
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View article: Figure S17 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S17 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 17. Characterization of monocyte subsets in each treatment group identifies varied effects.
View article: Figure S23 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 23. Tumor cells do not suppress Stat1 expression in naïve macrophages.
View article: Figure S19 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 19. Tumor cell secretions dampen the macrophage pro- inflammatory response to TLR agonism.
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Supplemental Figure 7. Combination therapy requires a sufficient number of cisplatin doses and daily BVT948 treatment.
View article: Figure S16 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 16. Neutrophil clusters and associated gene expression identify both pro- and anti-tumor subsets though there is a general expansion after combination therapy.
View article: Figure S12 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 12. Macrophage pathway analysis identifies upregulated signaling networks for each cluster
View article: Figure S5 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 5. Pros1 deficient tumors show reduced tumor growth after cisplatin treatment and increased immune activation.
View article: Figure S3 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 3. BVT948 treatment of early GEMM6 tumors results in some durable responses and reduces growth when combined with vemurafenib in larger tumors.
View article: Figure S2 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S2 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 2. The efficacy of chemotherapy is improved by PTP inhibition.
View article: Figure S22 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 22. Tumor cell secretions do not suppress MyD88 levels of naïve macrophages.
View article: Figure S29 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 29. PTP1b inhibition prevents Mer:PTP1b:Stat1 complex formation.
View article: Figure S15 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 15. The T cell population is reduced by cisplatin therapy and altered by BVT948 or combination therapy
View article: Figure S14 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 14. Intra-tumoral B cell subpopulations across different treatment groups
View article: Figure S24 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S24 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 24. Stat1 has two binding sites on the MyD88 promoter (proximal, distal) but tumor cell secretions do not affect association at the distal site.
View article: Figure S18 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S18 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 18. Immune cell signaling is altered between treatment groups.
View article: Figure S20 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S20 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 20. Cisplatin treated macrophages are not M1 activated.
View article: Figure S10 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 10. Changes in tumor immune cell composition following respective treatments.
View article: Figure S21 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 21. BVT948 treatment restores macrophage sensitivity to tumor DAMPs.
View article: Figure S9 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 9. Flow cytometry gating strategy to identify live CD45+ immune cells.
View article: Figure S1 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 1. PTP inhibition improves the efficacy of radiotherapy in limiting tumor growth in multiple preclinical models.
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Supplemental Figure 8. Two doses of cisplatin in combination with BVT948 PTP inhibition substantially reduces B16F10 tumor growth.
View article: Table S1 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Table S1 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Primers used in the study.
View article: Data from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Data from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Traditional anticancer therapies induce tumor cell death and subsequent release of damage-associated molecular patterns (DAMPs) that activate the innate inflammatory response. Paradoxically, after treatment, macrophages often adopt a pro–w…
View article: Figure S4 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 4. PTP inhibitors have limited effects on tumor cell viability in vitro and increase angiogenesis associated pathways in vivo.
View article: Figure S13 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S13 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 13. Macrophage signaling is affected by respective treatments.
View article: Figure S28 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 28. PTP1B-MER and PTP1B-insulin receptor tyrosine kinase complex structures show an overlapping binding surface on PTP1B.
View article: Figure S27 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
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Supplemental Figure 27. Macrophages isolated from Tyro3, Mer, and Axl knock-out mice respond equivalently to wildtype cells when stimulated with IFNγ+LPS.
View article: Figure S6 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S6 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 6. Encapsome and Isotype control treatment of tumor bearing mice do not significantly affect outcomes.
View article: Figure S26 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy
Figure S26 from PTP Inhibition Improves the Macrophage Antitumor Immune Response and the Efficacy of Chemo- and Radiotherapy Open
Supplemental Figure 26. Targeted siRNAs reduce tumor expression of Pros1 or Gas6.