Oksana Chepurna
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View article: Nano-Polymers as Cas9 Inhibitors
Nano-Polymers as Cas9 Inhibitors Open
Despite wide applications of CRISPR/Cas9 technology, effective approaches for CRISPR delivery with functional control are limited. In an attempt to develop a nanoscale CRSIPR/Cas9 delivery platform, we discovered that several biocompatible…
View article: Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation
Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation Open
Heating of core-thermoresponsive shell nanoparticles loaded with fluorescent molecules resulted in an increased fluorescence and singlet oxygen generation, which holds promise for thermally enhanced fluorescence bioimaging and photodynamic…
View article: Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction
Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction Open
We investigated the role of histone 3 lysine 9 trimethylation (H3K9me3), an epigenetic mechanism involved in the repression of synaptic plasticity and memory-related genes, within aging and Alzheimer’s disease (AD). Our study reveals that …
View article: Targeted Boron Neutron Capture Therapy Using Polymalic Acid Derived Nano-Boron to Treat Glioblastoma
Targeted Boron Neutron Capture Therapy Using Polymalic Acid Derived Nano-Boron to Treat Glioblastoma Open
Despite extensive efforts, glioblastoma multiforme (GBM), the most malignant brain cancer, continues to pose significant challenges to effective treatment, with limited progress in patient survival over the last three decades. This study a…
View article: Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes
Dual Stimuli‐Responsive Ternary Core‐Shell Polystyrene@Pnipam‐Pedot Latexes Open
The ability of stimuli‐responsive materials to respond to external stimuli depends on their intra‐ and intermolecular interactions, which, in turn, are governed by changes in the material composition. Here, the importance of these factors …
View article: Drug resistance in glioblastoma: from chemo- to immunotherapy
Drug resistance in glioblastoma: from chemo- to immunotherapy Open
As the most common and aggressive type of primary brain tumor in adults, glioblastoma is estimated to end over 10,000 lives each year in the United States alone. Stand treatment for glioblastoma, including surgery followed by radiotherapy …
View article: Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse study
Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse study Open
Air pollution poses a significant threat to human health, though a clear understanding of its mechanism remains elusive. In this study, we sought to better understand the effects of various sized particulate matter from polluted air on Alz…
View article: β-Amyloid targeting nanodrug for neuron-specific delivery of nucleic acids in Alzheimer's disease mouse models
β-Amyloid targeting nanodrug for neuron-specific delivery of nucleic acids in Alzheimer's disease mouse models Open
Delivery of therapeutic substances into the brain poses a significant challenge in the treatment of neurological disorders. This is primarily due to the blood-brain barrier (BBB), which restricts access, alongside the limited stability and…
View article: New Boron Delivery Agents
New Boron Delivery Agents Open
This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that…
View article: Study of the laser radiation effect in combination with doxorubicin on the survival of MCF7 and MCF7DOX culture cells
Study of the laser radiation effect in combination with doxorubicin on the survival of MCF7 and MCF7DOX culture cells Open
The use of lasers in oncology is constantly evolving. In recent years, the mechanisms of the effect of laser radiation, particularly of the infrared spectrum, on tumour cells in combination with various chemotherapeutic agents have been st…
View article: Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy
Multifunctional Magneto-Plasmonic Fe3O4/Au Nanocomposites: Approaching Magnetophoretically-Enhanced Photothermal Therapy Open
Magneto-plasmonic nanocomposites can possess properties inherent to both individual components (iron oxide and gold nanoparticles) and are reported to demonstrate high potential in targeted drug delivery and therapy. Herein, we report on F…
View article: Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex
Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex Open
A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon…
View article: To question of increasing of efficiency of photodynamic therapy of tumors on the basis of multispectral treatment and diagnostic device
To question of increasing of efficiency of photodynamic therapy of tumors on the basis of multispectral treatment and diagnostic device Open
Damage to tumor cells as a result of photodynamic therapy is a multi-stage process, the effectiveness of which depends on a number of factors, and in particular on the properties of the photosensitizer used and the parameters of light irra…