Ola Gutzeit
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View article: O-295 Analysis of human sperm behavior and assessment of non-hormonal contraceptive efficacy in a human cervix chip
O-295 Analysis of human sperm behavior and assessment of non-hormonal contraceptive efficacy in a human cervix chip Open
Study question Can a microfluidic Organ Chip model of the human cervix replicate cervical conditions to evaluate sperm translocation, motility and the efficacy of non-hormonal contraceptives? Summary answer Human Cervix Chip mimics the cer…
View article: Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health
Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health Open
Advancements in women's reproductive health have been hindered by insufficient knowledge and the underrepresentation of women in research, leading to symptom‐focused care with poor outcomes. Modeling female reproductive biology and disease…
View article: Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips
Induction of cervical dysfunction associated with preterm birth by IL-1 and dysbiotic microbiome revealed in human endocervix chips Open
Cervical dysfunction, a major contributor to preterm labor and neonatal mortality, remains poorly understood due to the absence of physiologically relevant human models. Here, we show that a microfluidic human Endocervix Chip lined by prim…
View article: P-574 Anti-Müllerian hormone: A novel marker for ovarian torsion?
P-574 Anti-Müllerian hormone: A novel marker for ovarian torsion? Open
Study question Can measuring plasma AMH levels assist in diagnosing ovarian torsion? Summary answer AMH levels show fluctuations during the acute phase of ovarian torsion, potentially aiding in clinical diagnosis. What is known already Ant…
View article: Modulation of dysbiotic vaginal complications by cervical mucus revealed in linked human vagina and cervix chips
Modulation of dysbiotic vaginal complications by cervical mucus revealed in linked human vagina and cervix chips Open
Background The cervicovaginal mucus which coats the upper surface of the vaginal epithelium is thought to serve as a selective barrier that helps to clear pathogens, however, its role in modulating the physiology and pathophysiology of the…
View article: Modulation of dysbiotic vaginal complications by cervical mucus revealed in linked human vagina and cervix chips
Modulation of dysbiotic vaginal complications by cervical mucus revealed in linked human vagina and cervix chips Open
Background The cervicovaginal mucus that coats the upper surface of the vaginal epithelium is thought to serve as a selective barrier that helps to clear pathogens, however, its role in modulating the physiology and pathophysiology of the …
View article: The Relationship between Preterm Premature Rupture of Membranes and Colonization of GBS - A Review
The Relationship between Preterm Premature Rupture of Membranes and Colonization of GBS - A Review Open
Purpose: Group B streptococcus (GBS) is the leading cause of newborn infection. The most important risk factor for this debilitating infection in newborns is maternal colonization of the genitourinary and gastrointestinal tracts. This revi…
View article: P-605 Hypoxia leads to diminished ovarian reserve in an age dependent manner
P-605 Hypoxia leads to diminished ovarian reserve in an age dependent manner Open
Study question To determine whether hypoxic ovarian damage is due to increased growth and follicles “burnout” or due increased apoptosis, and whether this damage is age dependent. Summary answer Direct tissue hypoxia causes activation and …
View article: O-019 Decreased Sperm Motility Associated With Bacterial Vaginosis Modeled in a Human Cervix Chip
O-019 Decreased Sperm Motility Associated With Bacterial Vaginosis Modeled in a Human Cervix Chip Open
Study question What is the underlying cause of infertility associated with bacterial vaginosis (BV)? Summary answer We provide the first evidence to suggest that BV-associated infertility could be the result of sperm dysfunction induced by…
View article: Intestine and brain TLR-4 modulation following N-acetyl-cysteine treatment in NEC rodent model
Intestine and brain TLR-4 modulation following N-acetyl-cysteine treatment in NEC rodent model Open
Necrotizing enterocolitis (NEC) brain injury is mediated through Toll-like receptor 4 (TLR4) on the intestinal epithelium and brain microglia. Our aim was to determine whether postnatal and/or prenatal NAC can modify NEC associated intesti…
View article: Hypoxia leads to diminished ovarian reserve in an age dependent manner
Hypoxia leads to diminished ovarian reserve in an age dependent manner Open
Objective In a previous study, we demonstrated that perinatal hypoxia leads to premature activation and initiation of growth in dormant follicles, leading to diminished ovarian reserve. Other reports have also established a connection betw…
View article: Double balloon device for labor induction in women with and without previous cesarean delivery
Double balloon device for labor induction in women with and without previous cesarean delivery Open
Purpose Induction of labor (IOL) after cesarean delivery is reasonable option and should be discussed. While IOL has been shown to be superior to expectant management in low-risk nulliparous women, the literature in women after cesarean de…
View article: Intestine and brain TLR-4 modulation following N-Acetyl-Cysteine treatment in NEC rodent model
Intestine and brain TLR-4 modulation following N-Acetyl-Cysteine treatment in NEC rodent model Open
Objective: Necrotizing enterocolitis (NEC) brain injury is mediated through Toll-like receptor 4 (TLR4) on the intestinal epithelium and on brain microglia. We sought to determine whether postnatal and/or prenatal NAC can modify NEC associ…
View article: Intestine and brain TLR-4 modulation following N-Acetyl-Cysteine treatment in NEC rodent model
Intestine and brain TLR-4 modulation following N-Acetyl-Cysteine treatment in NEC rodent model Open
Objective: Necrotizing enterocolitis (NEC) brain injury is mediated through Toll-like receptor 4 (TLR4) on the intestinal epithelium and on brain microglia. We sought to determine whether postnatal and/or prenatal NAC can modify NEC associ…
View article: Maternal N‐acetyl‐cysteine prevents neonatal brain injury associated with necrotizing enterocolitis in a rat model
Maternal N‐acetyl‐cysteine prevents neonatal brain injury associated with necrotizing enterocolitis in a rat model Open
Introduction Preterm infants with necrotizing enterocolitis (NEC) are at increased risk of cerebral injury and neurodevelopmental dysfunction. N‐acetyl‐cysteine (NAC) is a known anti‐inflammatory and antioxidant agent. Currently, there is …
View article: Prophylactic antenatal N-Acetyl Cysteine administration combined with postnatal administration can decrease mortality and injury markers associated with necrotizing enterocolitis in a rat model
Prophylactic antenatal N-Acetyl Cysteine administration combined with postnatal administration can decrease mortality and injury markers associated with necrotizing enterocolitis in a rat model Open
Antenatal NAC decreases injury markers and mortality associated with NEC in a rat model. Antenatal administration of NAC may present a novel approach for NEC prophylaxis in pregnancies with risk for preterm birth.
View article: Postpartum Female Sexual Function: Risk Factors for Postpartum Sexual Dysfunction
Postpartum Female Sexual Function: Risk Factors for Postpartum Sexual Dysfunction Open
Introduction Women's sexual health is a vital and important part of life at any age. In particular, pregnancy and childbirth bring biological, psychological, and social changes which may influence sexual health. It has been shown that sexu…