Ola Söderberg
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View article: Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling
Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling Open
The ability to analyze whether DNA contains lesions is essential in identifying mutagenic substances. Currently, the detection of single-stranded DNA breaks (SSBs) lacks precision. To address this limitation, we develop a method for sequen…
View article: Crosstalk between 1,25(OH)2-Vitamin D3 and the growth factors EGF and PDGF-BB: Impact on CYP24A1 expression and cell proliferation
Crosstalk between 1,25(OH)2-Vitamin D3 and the growth factors EGF and PDGF-BB: Impact on CYP24A1 expression and cell proliferation Open
This study explored the signaling interplay between the vitamin D receptor (VDR) and receptor tyrosine kinases (RTKs). Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-BB promotes cell proliferation in normal and can…
View article: Precise mapping of single-stranded DNA breaks by using an engineered, error-prone DNA polymerase for sequence-templated erroneous end-labelling
Precise mapping of single-stranded DNA breaks by using an engineered, error-prone DNA polymerase for sequence-templated erroneous end-labelling Open
The ability to analyze whether DNA includes lesions is important in identifying mitogenic substances. Until now, the detection of single-stranded DNA breaks (SSBs) has lacked precise methods. To overcome this limitation, we have engineered…
View article: PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells
PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells Open
Platelet-derived growth factor (PDGF)-induced signalling via PDGF receptor β (PDGFRβ) leads to activation of downstream signalling pathways which regulate multiple cellular responses. It is unclear how PDGFRβ is degraded; both lysosomal an…
View article: The method developer’s guide to oligonucleotide design
The method developer’s guide to oligonucleotide design Open
Understanding how the methods work is important in selecting an appropriate method for your experiments. We also hope that this paper may be an inspiration for young researchers to enter the field of method development. Seeing a problem is…
View article: Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling
Visualizing DNA single- and double-strand breaks in the Flash comet assay by DNA polymerase-assisted end-labelling Open
In the comet assay, tails are formed after single-cell gel electrophoresis if the cells have been exposed to genotoxic agents. These tails include a mixture of both DNA single-strand breaks (SSBs) and double-strand breaks (DSBs). However, …
View article: Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion
Activated EGFR and PDGFR internalize in separate vesicles and downstream AKT and ERK1/2 signaling are differentially impacted by cholesterol depletion Open
The interplay between membrane subregions and receptor tyrosine kinases (RTK) will influence signaling in both normal and pathological RTK conditions. In this study, epidermal growth factor receptor (EGFR) and platelet-derived growth facto…
View article: Supplementary Figures 1-10 from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Supplementary Figures 1-10 from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
Supplementary Fig. S1: Tissue microarray VN:IGFBP-3 PLA immunoreactivity and patient information; Supplementary Fig. S2: VN peptide array amino acid sequence information; Supplementary Fig. S3: IGFBP-3 peptide array amino acid sequence inf…
View article: Supplementary Figures 1-10 from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Supplementary Figures 1-10 from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
Supplementary Fig. S1: Tissue microarray VN:IGFBP-3 PLA immunoreactivity and patient information; Supplementary Fig. S2: VN peptide array amino acid sequence information; Supplementary Fig. S3: IGFBP-3 peptide array amino acid sequence inf…
View article: Data from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Data from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
We provide proof-of-concept evidence for a new class of therapeutics that target growth factor:extracellular matrix (GF:ECM) interactions for the management of breast cancer. Insulin-like growth factor-I (IGF-I) forms multiprotein complexe…
View article: Supplementary Matierial from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Supplementary Matierial from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
Supplementary materials and methods
View article: Data from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Data from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
We provide proof-of-concept evidence for a new class of therapeutics that target growth factor:extracellular matrix (GF:ECM) interactions for the management of breast cancer. Insulin-like growth factor-I (IGF-I) forms multiprotein complexe…
View article: Supplementary Matierial from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions
Supplementary Matierial from Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I–Induced Breast Cancer Cell Functions Open
Supplementary materials and methods
View article: Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Data from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Data from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-reso…
View article: Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Figure 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Data from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Data from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
This study was designed to identify highly recurrent genetic alterations typical of Sézary syndrome (Sz), an aggressive cutaneous T-cell lymphoma/leukemia, possibly revealing pathogenetic mechanisms and novel therapeutic targets. High-reso…
View article: Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 2 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 4 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 3 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
View article: Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome
Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sezary Syndrome Open
Supplementary Table 1 from Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome