Ola Wallerman
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View article: Ecological genomics in the Northern krill uncovers loci for local adaptation across ocean basins
Ecological genomics in the Northern krill uncovers loci for local adaptation across ocean basins Open
Krill are vital as food for many marine animals but also impacted by global warming. To learn how they and other zooplankton may adapt to a warmer world we studied local adaptation in the widespread Northern krill ( Meganyctiphanes norvegi…
View article: High-Quality Genome Assemblies of 4 Members of the <i>Podospora anserina</i> Species Complex
High-Quality Genome Assemblies of 4 Members of the <i>Podospora anserina</i> Species Complex Open
The filamentous fungus Podospora anserina is a model organism used extensively in the study of molecular biology, senescence, prion biology, meiotic drive, mating-type chromosome evolution, and plant biomass degradation. It has recently be…
View article: High-quality genome assemblies of four members of the<i>Podospora anserina</i>species complex
High-quality genome assemblies of four members of the<i>Podospora anserina</i>species complex Open
The filamentous fungus Podospora anserina is a model organism used extensively in the study of molecular biology, senescence, prion biology, meiotic drive, mating-type chromosome evolution, and plant biomass degradation. It has recently be…
View article: Evolutionary constraint and innovation across hundreds of placental mammals
Evolutionary constraint and innovation across hundreds of placental mammals Open
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases …
View article: Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Leveraging base-pair mammalian constraint to understand genetic variation and human disease Open
Thousands of genomic regions have been associated with heritable human diseases, but attempts to elucidate biological mechanisms are impeded by an inability to discern which genomic positions are functionally important. Evolutionary constr…
View article: Ecological genomics in the Northern krill uncovers loci for local adaptation across ocean basins
Ecological genomics in the Northern krill uncovers loci for local adaptation across ocean basins Open
Krill is a vital food source for many marine animals but also strongly impacted by climate change. Genetic adaptation could support populations, but remains uncharacterized. We assembled the 19 Gb Northern krill genome and compared genome-…
View article: Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease
Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease Open
Although thousands of genomic regions have been associated with heritable human diseases, attempts to elucidate biological mechanisms are impeded by a general inability to discern which genomic positions are functionally important. Evoluti…
View article: Evolutionary constraint and innovation across hundreds of placental mammals
Evolutionary constraint and innovation across hundreds of placental mammals Open
Evolutionary constraint and acceleration are powerful, cell-type agnostic measures of functional importance. Previous studies in mammals were limited by species number and reliance on human-referenced alignments. We explore the evolution o…
View article: Rapid adaptive radiation of Darwin’s finches depends on ancestral genetic modules
Rapid adaptive radiation of Darwin’s finches depends on ancestral genetic modules Open
Recent adaptive radiations are models for investigating mechanisms contributing to the evolution of biodiversity. An unresolved question is the relative importance of new mutations, ancestral variants, and introgressive hybridization for p…
View article: Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut
Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut Open
Atlantic Halibut ( Hippoglossus hippoglossus ) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly from a male and identified parts of chromosome 13 as the Y c…
View article: A genomic and morphometric analysis of alpine bumblebees: Ongoing reductions in tongue length but no clear genetic component
A genomic and morphometric analysis of alpine bumblebees: Ongoing reductions in tongue length but no clear genetic component Open
Over the last six decades, populations of the bumblebees Bombus sylvicola and Bombus balteatus in Colorado have experienced decreases in tongue length, a trait important for plant‐pollinator mutualisms. It has been hypothesized that this o…
View article: Darwin’s finches - an adaptive radiation constructed from ancestral genetic modules
Darwin’s finches - an adaptive radiation constructed from ancestral genetic modules Open
Recent adaptive radiations are models for investigating mechanisms contributing to the evolution of biodiversity. An unresolved question is the relative importance of new mutations, ancestral variants, and introgressive hybridization for p…
View article: The <i>Enterprise</i> , a massive transposon carrying <i>Spok</i> meiotic drive genes
The <i>Enterprise</i> , a massive transposon carrying <i>Spok</i> meiotic drive genes Open
The genomes of eukaryotes are full of parasitic sequences known as transposable elements (TEs). Here, we report the discovery of a putative giant tyrosine-recombinase-mobilized DNA transposon, Enterprise , from the model fungus Podospora a…
View article: Genetic Barriers to Historical Gene Flow between Cryptic Species of Alpine Bumblebees Revealed by Comparative Population Genomics
Genetic Barriers to Historical Gene Flow between Cryptic Species of Alpine Bumblebees Revealed by Comparative Population Genomics Open
Evidence is accumulating that gene flow commonly occurs between recently diverged species, despite the existence of barriers to gene flow in their genomes. However, we still know little about what regions of the genome become barriers to g…
View article: A genomic and morphometric analysis of alpine bumblebees: ongoing reductions in tongue length but no clear genetic component
A genomic and morphometric analysis of alpine bumblebees: ongoing reductions in tongue length but no clear genetic component Open
Over the last six decades, populations of the bumblebees Bombus sylvicola and Bombus balteatus in Colorado have experienced decreases in tongue length, a trait important for plant-pollinator mutualisms. It has been hypothesized that this o…
View article: Heterochiasmy facilitated the establishment of<i>gsdf</i>as a novel sex determining gene in Atlantic halibut
Heterochiasmy facilitated the establishment of<i>gsdf</i>as a novel sex determining gene in Atlantic halibut Open
Atlantic Halibut (Hippoglossus hippoglossus) has a X/Y genetic sex determination system, but the sex determining factor is not known. We produced a high-quality genome assembly and identified parts of chromosome 13 as the Y chromosome due …
View article: The Human Adenovirus 2 Transcriptome: an Amazing Complexity of Alternatively Spliced mRNAs
The Human Adenovirus 2 Transcriptome: an Amazing Complexity of Alternatively Spliced mRNAs Open
Work in the adenovirus system led to the groundbreaking discovery of RNA splicing and alternative RNA splicing in 1977. These mechanisms are essential in mammalian evolution, as they increase the coding capacity of a genome.
View article: Reconstruction of the birth of a male sex chromosome present in Atlantic herring
Reconstruction of the birth of a male sex chromosome present in Atlantic herring Open
Significance Understanding the evolution of sex determination mechanisms and sex chromosomes is of fundamental importance in biology. Here we have reconstructed the evolution of the sex-determining region in the Atlantic herring. The regio…
View article: GSD_1.0 (canFam4): A novel canine reference genome resolves genomic architecture and uncovers transcript complexity
GSD_1.0 (canFam4): A novel canine reference genome resolves genomic architecture and uncovers transcript complexity Open
We present GSD_1.0, a novel high-quality domestic dog reference genome with chromosome length scaffolds and gap number reduced 41-fold, from 23,836 to 585. Annotation with novel and existing long and short read RNA-seq, miRNA-seq and ATAC-…
View article: A new long-read dog assembly uncovers thousands of exons and functional elements missing in the previous reference
A new long-read dog assembly uncovers thousands of exons and functional elements missing in the previous reference Open
Here we present a new high-quality canine reference genome with gap number reduced 41-fold, from 23,836 to 585. Analysis of existing and novel data, RNA-seq, miRNA-seq and ATAC-seq, revealed a large proportion of these harboured previously…
View article: The<i>Enterprise</i>: A massive transposon carrying<i>Spok</i>meiotic drive genes
The<i>Enterprise</i>: A massive transposon carrying<i>Spok</i>meiotic drive genes Open
The genomes of eukaryotes are full of parasitic sequences known as transposable elements (TEs). Most TEs studied to date are relatively small (50 – 12000 bp), but can contribute to very large proportions of genomes. Here we report the disc…
View article: A chromosome-level assembly of the Atlantic herring genome—detection of a supergene and other signals of selection
A chromosome-level assembly of the Atlantic herring genome—detection of a supergene and other signals of selection Open
The Atlantic herring is a model species for exploring the genetic basis for ecological adaptation, due to its huge population size and extremely low genetic differentiation at selectively neutral loci. However, such studies have so far bee…
View article: A chromosome-level assembly of the Atlantic herring – detection of a supergene and other signals of selection
A chromosome-level assembly of the Atlantic herring – detection of a supergene and other signals of selection Open
The Atlantic herring is a model species for exploring the genetic basis for ecological adaptation, due to its huge population size and extremely low genetic differentiation at selectively neutral loci. However, such studies have so far bee…
View article: Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard Open
Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympa…
View article: Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases
Allele specific chromatin signals, 3D interactions, and motif predictions for immune and B cell related diseases Open
Several Genome Wide Association Studies (GWAS) have reported variants associated to immune diseases. However, the identified variants are rarely the drivers of the associations and the molecular mechanisms behind the genetic contributions …
View article: Regulatory Changes in Pterin and Carotenoid Genes Underlie Balanced Color Polymorphisms in the Wall Lizard
Regulatory Changes in Pterin and Carotenoid Genes Underlie Balanced Color Polymorphisms in the Wall Lizard Open
Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympa…