Olaf Pongs
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View article: Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages
Myristoylated Neuronal Calcium Sensor-1 captures the preciliary vesicle at distal appendages Open
The primary cilium is a microtubule-based organelle that cycles through assembly and disassembly. In many cell types, formation of the cilium is initiated by recruitment of preciliary vesicles to the distal appendage of the mother centriol…
View article: Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages
Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages Open
Summary The primary cilium is a microtubule-based organelle that cycles through assembly and disassembly. In many cell types, formation of the cilium is initiated by recruitment of ciliary vesicles to the distal appendage of the mother cen…
View article: NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons
NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons Open
Neuronal Ca2+ sensor proteins (NCS) transduce changes in Ca2+ homeostasis into altered signaling and neuronal function. NCS-1 activity has emerged as important for neuronal viability and pathophysiology. The progressive degeneration of dop…
View article: Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease Open
Degeneration of dopaminergic neurons in the substantia nigra causes the motor symptoms of Parkinson’s disease. The mechanisms underlying this age-dependent and region-selective neurodegeneration remain unclear. Here we identify Cav2.3 chan…
View article: Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom
Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom Open
MiDCA1, a phospholipase A2 (PLA2) neurotoxin isolated from Micrurus dumerilii carinicauda coral snake venom, inhibited a major component of voltage-activated potassium (Kv) currents (41 ± 3% inhibition with 1 μM toxin) in mouse cultured do…
View article: NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice
NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice Open
Neuronal calcium sensor-1 (NCS-1) knockout (KO) in mice (NCS-1-/- mice) evokes behavioral phenotypes ranging from learning deficits to avolition and depressive-like behaviors. Here, we showed that with the onset of adulthood NCS-1-/- mice …