Oldřich Bartoš
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View article: Sex Chromosome Turnover and Structural Interspecific Genome Divergence Shapes Meiotic Outcomes in Hybridizing <i>Cobitis</i>
Sex Chromosome Turnover and Structural Interspecific Genome Divergence Shapes Meiotic Outcomes in Hybridizing <i>Cobitis</i> Open
It has been empirically established that genome mixing between divergent species can trigger meiotic aberrations, ultimately leading to the emergence of asexual reproduction through the production of unreduced gametes in various metazoan l…
View article: Evaluation of Soluble Urokinase Plasminogen Activator Receptor in COVID-19 Patients
Evaluation of Soluble Urokinase Plasminogen Activator Receptor in COVID-19 Patients Open
Background/Objectives: This retrospective study analyzed soluble urokinase plasminogen activator receptor (suPAR) plasma levels alongside routine inflammatory markers, including the neutrophil-to-lymphocyte count ratio, C-reactive protein …
View article: Haemoglobin Gene Repertoire in Teleost and Cichlid Fishes Shaped by Gene Duplications and Genome Rearrangements
Haemoglobin Gene Repertoire in Teleost and Cichlid Fishes Shaped by Gene Duplications and Genome Rearrangements Open
Haemoglobin is a key molecule for oxygen transport in vertebrates. It exhibits remarkable gene diversity in teleost fishes, reflecting adaptation to various aquatic environments. In this study, we present the dynamic evolution of haemoglob…
View article: Author Correction: The overlooked evolutionary dynamics of 16S rRNA revises its role as the “gold standard” for bacterial species identification
Author Correction: The overlooked evolutionary dynamics of 16S rRNA revises its role as the “gold standard” for bacterial species identification Open
View article: The overlooked evolutionary dynamics of 16S rRNA revises its role as the “gold standard” for bacterial species identification
The overlooked evolutionary dynamics of 16S rRNA revises its role as the “gold standard” for bacterial species identification Open
View article: Multiple and frequent trypanosomatid co-infections of insects: the Cuban case study
Multiple and frequent trypanosomatid co-infections of insects: the Cuban case study Open
Trypanosomatids are obligate parasites of animals, predominantly insects and vertebrates, and flowering plants. Monoxenous species, representing the vast majority of trypanosomatid diversity, develop in a single host, whereas dixenous spec…
View article: Hemoglobin gene repertoire in teleost and cichlid fishes shaped by gene duplications and genome rearrangements
Hemoglobin gene repertoire in teleost and cichlid fishes shaped by gene duplications and genome rearrangements Open
Hemoglobin is a crucial element of the oxygen transport system in vertebrates. It exhibits remarkable gene diversity across teleost fishes, reflecting their evolutionary adaptations for thriving in various aquatic environments. In this stu…
View article: Prevalence of SARS-CoV-2 variants in Prague wastewater determined by nanopore-based sequencing
Prevalence of SARS-CoV-2 variants in Prague wastewater determined by nanopore-based sequencing Open
The early detection of upcoming disease outbreaks is essential to avoid both health and economic damage. The last four years of COVID-19 pandemic have proven wastewater-based epidemiology is a reliable system for monitoring the spread of S…
View article: Two novel Bartonella (sub)species isolated from edible dormice (Glis glis): hints of cultivation stress-induced genomic changes
Two novel Bartonella (sub)species isolated from edible dormice (Glis glis): hints of cultivation stress-induced genomic changes Open
Bartonelloses are neglected emerging infectious diseases caused by facultatively intracellular bacteria transmitted between vertebrate hosts by various arthropod vectors. The highest diversity of Bartonella species has been identified in r…
View article: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Author Response: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Author Response: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract Asexual reproduction c…
View article: Specific immune responses after BNT162b2 mRNA vaccination and COVID-19 infection
Specific immune responses after BNT162b2 mRNA vaccination and COVID-19 infection Open
Although vaccines against COVID-19 are effective tools in preventing severe disease, recent studies have shown enhanced protection after vaccine boosters. The aim of our study was to examine the dynamics and duration of both humoral and ce…
View article: Reviewer #1 (Public Review): Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Reviewer #1 (Public Review): Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Author Response: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Author Response: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Sequence capture: Obsolete or irreplaceable? A thorough validation across phylogenetic distances and its applicability to hybrids and allopolyploids
Sequence capture: Obsolete or irreplaceable? A thorough validation across phylogenetic distances and its applicability to hybrids and allopolyploids Open
As whole‐genome sequencing has become pervasive, some have suggested that reduced genomic representation approaches, for example, sequence capture, are becoming obsolete. In the present study, we argue that these techniques still provide e…
View article: Genetic and karyotype divergence between parents affect clonality and sterility in hybrids
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids Open
Asexual reproduction can be triggered by interspecific hybridization, but its emergence is supposedly rare, relying on exceptional combinations of suitable genomes. To examine how genomic and karyotype divergence between parental lineages …
View article: Is soluble urokinase plasminogen activator receptor levels still a prognostic biomarker of COVID-19 in the Omicron era?
Is soluble urokinase plasminogen activator receptor levels still a prognostic biomarker of COVID-19 in the Omicron era? Open
The authors have requested that this preprint be removed from Research Square.
View article: Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation
Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation Open
In vertebrates, cannabinoids modulate neuroimmune interactions through two cannabinoid receptors (CNRs) conservatively expressed in the brain (CNR1, syn. CB1) and in the periphery (CNR2, syn. CB2). Our comparative genomic analysis indicate…
View article: Retrospective Analysis Revealed an April Occurrence of Monkeypox in the Czech Republic
Retrospective Analysis Revealed an April Occurrence of Monkeypox in the Czech Republic Open
Herein, we present our findings of an early appearance of the Monkeypox virus in Prague, Czech Republic. A retrospective analysis of biological samples, carried out on the 28th of April, revealed a previously unrecognized case of Monkeypox…
View article: Revealing genomic changes responsible for cannabinoid receptor loss in parrots: mechanism and functional effects
Revealing genomic changes responsible for cannabinoid receptor loss in parrots: mechanism and functional effects Open
In vertebrates, an ancient duplication in the genes for cannabinoid receptors (CNRs) allowed the evolution of specialised endocannabinoid receptors expressed in the brain (CNR1) and the periphery (CNR2). While dominantly conserved througho…
View article: Acute phase of COVID-19 is associated with elevated plasmablasts in the blood
Acute phase of COVID-19 is associated with elevated plasmablasts in the blood Open
Severe course of COVID-19 is associated with significant changes of phenotypes of circulating B-lymphocytes and elevated circulating plasmablasts correlate with decreased SARS-CoV-2-specific IgG antibodies (Tab. 2, Fig. 3, Ref. 14).
View article: Supplementary Data from Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation
Supplementary Data from Cannabinoid receptor 2 evolutionary gene loss makes parrots more susceptible to neuroinflammation Open
Table S21: Putative presence or absence of given immune gene (based on GO term: “negative regulation of inflammatory response“, GO:0050728) based on Avian Immunome database (AVIMM, Mueller et. al. 2020). Chicken gene annotation is used. Ge…
View article: Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication
Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication Open
Parvalbumin is considered a major fish allergen. Here, we report the molecular evolution of the parvalbumin genes in bony fishes based on 19 whole genomes and 70 transcriptomes. We found unexpectedly high parvalbumin diversity in teleosts;…
View article: Genome Fractionation and Loss of Heterozygosity in Hybrids and Polyploids: Mechanisms, Consequences for Selection, and Link to Gene Function
Genome Fractionation and Loss of Heterozygosity in Hybrids and Polyploids: Mechanisms, Consequences for Selection, and Link to Gene Function Open
Hybridization and genome duplication have played crucial roles in the evolution of many animal and plant taxa. The subgenomes of parental species undergo considerable changes in hybrids and polyploids, which often selectively eliminate seg…
View article: Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells
Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells Open
Background. Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response. Objective. The aim of the study was to characterize functional alterations in CD4+ T cell subsets and myeloid-derived suppressor cells (MDSCs) …
View article: Salmonella Paratyphi Infection: Use of Nanopore Sequencing as a Vivid Alternative for the Identification of Invading Bacteria
Salmonella Paratyphi Infection: Use of Nanopore Sequencing as a Vivid Alternative for the Identification of Invading Bacteria Open
In our study we present an overview of the use of Oxford Nanopore Technologies (ONT) sequencing technology on the background of Enteric fever. Unlike traditional methods (e.g., qPCR, serological tests), the nanopore sequencing technology e…
View article: Exosomes released by imatinib‑resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib‑sensitive cells in the presence of imatinib
Exosomes released by imatinib‑resistant K562 cells contain specific membrane markers, IFITM3, CD146 and CD36 and increase the survival of imatinib‑sensitive cells in the presence of imatinib Open
Chronic myeloid leukemia (CML) is a malignant hematopoietic disorder distinguished by the presence of a BCR‑ABL1 fused oncogene with constitutive kinase activity. Targeted CML therapy by specific tyrosine kinase inhibitors (TKIs) leads to …