Explanipedia

SAT-337 Utility of BRAFV600E Immunohistochemistry in Differentiated Thyroid Carcinoma Open

Mareike Graff, Abbey Fingeret, Oleg Shats, Cheng Zheng, Benjamin Swanson , et al. · 2025

Disclosure: M.R. Graff: None. A. Fingeret: None. O. Shats: None. C. Zheng: None. B. Swanson: None. W.S. Goldner: None. A. Kotwal: None. Background: Differentiated thyroid carcinoma (DTC), specifically papillary thyroid cancer (PTC), is the…

Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska Open

Cassie Liu, Kaeli Samson, Oleg Shats, Raymond C. Bergan · 2025

Introduction Studies focused on rural–urban disparities in patients with prostate cancer have demonstrated minimal differences in incidence and overall survival (OS). However, available data are limited, especially in understudied geograph…

Characterization of Immune Infiltrate Along the Leading Edge of Differentiated Thyroid Cancer Open

Anupam Kotwal, Krysten E. Vance, Kemal Hajric, Ana Yuil‐Valdes, Benjamin Swanson , et al. · 2024

Background: Although the impact of tumor-immune infiltrate has been reported on differentiated thyroid cancer (DTC) behavior, the expression of immune checkpoints [programmed cell death protein 1 (PD-1) and its ligand (PD-L1)…

Relaxin-2 is a novel biomarker for differentiated thyroid carcinoma in humans Open

Anupam Kotwal, Ronda Simpson, Nicholas Whiteman, Benjamin Swanson, Ana Yuil‐Valdes , et al. · 2024

SAT524 Relaxin: A Novel Marker for Pro-Tumoral Thyroid Cancer Microenvironment? Open

Anupam Kotwal, Robert G. Bennett, Benjamin Swanson, Whitney Goldner, Ana Yuil‐Valdes , et al. · 2023

Disclosure: A. Kotwal: None. R.G. Bennett: None. B. Swanson: None. W. Goldner: None. A. Yuil-Valdes: None. N. Whiteman: None. O. Shats: None. Background: Differentiated thyroid cancer (DTC) generally has a favorable prognosis, however, 30%…

The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers Open

Neetha Nanoth Vellichirammal, Yuan-De Tan, Peng Xiao, James D. Eudy, Oleg Shats , et al. · 2023

Background Female breast cancer remains the second leading cause of cancer-related death in the USA. The heterogeneity in the tumor morphology across the cohort and within patients can lead to unpredictable therapy resistance, metastasis, …

The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers Open

NN Vellichirammal, YD Tan, Peng Xiao, JD Eudy, Oleg Shats , et al. · 2023

Additional supplementary figures and tables that were not included in the main manuscript's supplementary files, but referenced in the main manuscript for supporting data.

The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers Open

NN Vellichirammal, YD Tan, Peng Xiao, JD Eudy, Oleg Shats , et al. · 2023

Additional supplementary figures and tables that were not included in the main manuscript's supplementary files, but referenced in the main manuscript for supporting data.

Receptor for hyaluronan‐mediated motility ( <span>RHAMM</span> ) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients Open

Sarah E Tarullo, Yuyu He, Claire Daughters, Todd P. Knutson, Christine Henzler , et al. · 2023

Breast cancer invasion and metastasis result from a complex interplay between tumor cells and the tumor microenvironment (TME). Key oncogenic changes in the TME include aberrant synthesis, processing, and signaling of hyaluronan (HA). Hyal…

Additional file 1 of The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers Open

Neetha Nanoth Vellichirammal, Yuan-De Tan, Peng Xiao, James D. Eudy, Oleg Shats , et al. · 2023

Additional file 1. Supplementary Tables S1-S14. Table S1: Cancer associated variants differentially mutated across tumor grade. Table S2: Co-occuring or mutually exclusive mutations in Grade1. Table S3: MutSig CV results Grade1. Table S4: …

Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients Open

Sarah E Tarullo, Yuyu He, Claire Daughters, Todd P. Knutson, Christine Henzler , et al. · 2022

Breast cancer invasion and metastasis result from a complex interplay between tumor cells and the tumor microenvironment (TME). Key oncogenic changes in the TME include aberrant metabolism and subsequent signaling of hyaluronan (HA). Hyalu…

Impaired Sleep Influences Health Care Related Quality of Life in Patients With Well Differentiated Thyroid Carcinoma Open

Domenic Disanti, Abbey Fingeret, Sapna Raghunathan, Oleg Shats, Caroline Ouellette , et al. · 2021

Background: Most patients with well differentiated thyroid carcinoma (WDTC) have a favorable prognosis but often report lower health care related quality of life (HRQoL). Sleep quality is one contributor to HRQoL that has also been reporte…

Should BRAFV600E be Incorporated into Treatment Recommendations for Thyroid Cancer Open

Madelyn Fitch, Whitney Goldner, Benjamin Swanson, Abbey Fingeret, Oleg Shats , et al. · 2021

Around 90% of all well-differentiated thyroid cancers are papillary thyroid carcinomas (PTC). PTCs have a recurrence rate of around 20% and a low mortality rate of around 5%. Within PTCs, around 60% of them have the BRAFV600E mutation. Cur…

Investigating Immune Profiles in Differentiated Thyroid Cancer by Multiplex Immunofluorescence Open

Kemal Hajric, Krysten Vance Bs, Ernesto Martinez Duarte, Ana Yuil‐Valdes, Michael A. Hollingsworth , et al. · 2021

BACKGROUND: As the most common endocrine malignancy in the United States (U.S.), differentiated thyroid cancer (DTC) accounts for 3.8% of all cancers in the U.S., with roughly 10% of cases progressing to distant metastatic DTC, which is as…

Thyroid Cancer and Tumor Collaborative Registry (TCCR). Open

Oleg Shats, Whitney Goldner, Jianmin Feng, Alexander Sherman, Russell B. Smith , et al. · 2016

A multicenter, web-based Thyroid Cancer and Tumor Collaborative Registry (TCCR, http://tccr.unmc.edu) allows for the collection and management of various data on thyroid cancer (TC) and thyroid nodule (TN) patients. The TCCR is coupled wit…

Thyroid Cancer and Tumor Collaborative Registry (TCCR) Open

Oleg Shats, Whitney Goldner, Jianmin Feng, Alexander Sherman, Russell B. Smith , et al. · 2016

A multicenter, web-based Thyroid Cancer and Tumor Collaborative Registry (TCCR, http://tccr.unmc.edu ) allows for the collection and management of various data on thyroid cancer (TC) and thyroid nodule (TN) patients. The TCCR is coupled wi…

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