Olga Andrini
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View article: <i>Caenorhabditis elegans</i> as an <i>in vivo</i> model system for human inherited primary arrhythmia syndromes
<i>Caenorhabditis elegans</i> as an <i>in vivo</i> model system for human inherited primary arrhythmia syndromes Open
Inherited primary arrhythmia syndromes (IPAS) are genetic heart diseases associated with an elevated risk of sudden cardiac death, particularly in young individuals. Modelling these rare and serious conditions is essential to elucidate the…
View article: Constitutive sodium permeability in a <i>Caenorhabditis elegans</i> two-pore domain potassium channel
Constitutive sodium permeability in a <i>Caenorhabditis elegans</i> two-pore domain potassium channel Open
Two-pore domain potassium (K2P) channels play a central role in modulating cellular excitability and neuronal function. The unique structure of the selectivity filter in K2P and other potassium channels determines their ability to allow th…
View article: Constitutive sodium permeability in a<i>C. elegans</i>two-pore domain potassium channel
Constitutive sodium permeability in a<i>C. elegans</i>two-pore domain potassium channel Open
SUMMARY Two-pore domain potassium (K2P) channels play a central role in modulating cellular excitability and neuronal function. The unique structure of the selectivity filter in K2P and other potassium channels determines their ability to …
View article: Clinical and Genetic Spectrum of Bartter Syndrome Type 3
Clinical and Genetic Spectrum of Bartter Syndrome Type 3 Open
Bartter syndrome type 3 is a clinically heterogeneous hereditary salt-losing tubulopathy caused by mutations of the chloride voltage-gated channel Kb gene ( CLCNKB ), which encodes the ClC-Kb chloride channel involved in NaCl reabsorption …
View article: The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron
The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron Open
Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and potassium homeostasis. Chloride uptake from the urinary fluid is mediated by various apical transporters, whereas basolateral chloride exit is thoug…
View article: ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3
ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3 Open
The mutations in the CLCNKB gene encoding the ClC-Kb chloride channel are responsible for Bartter syndrome type 3, one of the four variants of Bartter syndrome in the genetically based nomenclature. All forms of Bartter syndrome are charac…