Explanipedia

Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes Open

Hila Milo Rasouly, Sarath Babu Krishna Murthy, Natalie Vena, Gundula Povysil, Andrew Beenken , et al. · 2025

#2966 Indirect evaluation of bone metabolism in dialysis: do we all have the same bones? Open

Matteo Righini, Anna Mistretta, Martina Titone, Davide Martelli, Lilio Hu , et al. · 2025

Background and Aims Bone disorders have emerged as a new area of study in the context of autosomal dominant polycystic kidney diseases (ADPKD). The observed bone defect in patients with ADPKD is discernibly different from the presentation …

Exome analysis links kidney malformations to developmental disorders and reveals causal genes Open

Hila Milo Rasouly, Sarath Babu Krishna Murthy, Natalie Vena, Gundula Povysil, Andrew Beenken , et al. · 2025

Bloodstream Infection Caused by Raoultella ornithinolytica in a Chronic Hemodialysis Patient Open

Matteo Righini, Martina Titone, Davide Martelli, Elisabetta Isola, Elena Tampieri , et al. · 2025

Bloodstream infections are a significant cause of morbidity and mortality among hemodialysis patients. These infections primarily involve Gram-positive bacteria and, less frequently, Gram-negative bacilli. Raoultella ornithinolytica is a G…

Individualized Diets in Patients with Kidney Disease and Kidney Transplants: A Narrative Review Open

Lilio Hu, Greta Borelli, Elisa Gessaroli, Chiara Ruotolo, Sofia Bin , et al. · 2025

Chronic kidney disease (CKD) is a widespread condition with significant cardiovascular risks and a progression to end-stage kidney failure. In recent years, increasing attention has been paid to the role of dietary interventions as a facto…

Exome-wide analysis of congenital kidney anomalies reveals new genes and shared architecture with developmental disorders Open

Hila Milo Rasouly, Sarath Babu Krishna Murthy, Natalie Vena, Gundula Povysil, Andrew Beenken , et al. · 2024

Kidney anomalies (KA) are developmental disorders that commonly cause pediatric chronic kidney disease and mortality. We examined rare coding variants in 248 KA trios and 1,742 singleton KA cases and compared them to 22,258 controls. Diagn…

Role of serum complement C3 and C4 on kidney outcomes in IgA nephropathy Open

Edoardo Tringali, Daniele Vetrano, Francesco Tondolo, Federica Maritati, Benedetta Fabbrizio , et al. · 2024

Looking for a new role of known players: the additional value of plasmatic C3 and C4 in predicting IgA Nephropathy prognosis, an observational study Open

Edoardo Tringali, Daniele Vetrano, Francesco Tondolo, Federica Maritati, Benedetta Fabbrizio , et al. · 2024

Introduction IgA Nephropathy (IgAN) is the prevalent glomerular disease worldwide. Complement system activation is crucial in its pathogenesis. Few studies correlated serum C3 and C4 with disease activity and prognosis. Methods This retros…

Estimated glomerular filtration rate in observational and interventional studies in chronic kidney disease Open

Michele Provenzano, Lilio Hu, Chiara Abenavoli, Giuseppe Cianciolo, Giuseppe Coppolino , et al. · 2024

Estimated glomerular filtration rate is considered the principal measure of kidney function and, together with albuminuria, is a relevant prognostic factor for the development of end-stage kidney disease. Due to the strong association betw…

Role of Estimated Glomerular Filtration Rate in Clinical Research: The Never-Ending Matter Open

Chiara Abenavoli, Michele Provenzano, Sara H. Ksiazek, Lilio Hu, Vania Cuna , et al. · 2024

Background: Chronic kidney disease (CKD) burden is crucial both on a global scale and at individual patient level, affecting morbidity and mortality directly and through its effect on both cardiovascular damage and CKD progression to end-s…

Rituximab as possible therapy in TNF inhibitor-induced IgA vasculitis with severe renal involvement Open

Agnieszka Przygocka, Gian Marco Berti, Anita Campus, Francesco Tondolo, Gisella Vischini , et al. · 2023

Background We observe the increasing use of tumor necrosis factor (TNF) inhibitors in patients affected by chronic inflammatory diseases. These drugs provide good control of symptoms, contributing to significant improvement in the quality …

Lessons for the clinical nephrologist: acute kidney injury during therapy with apixaban Open

Gisella Vischini, S. Speciale, Agnieszka Przygocka, L. Martano, Gaetano La Manna , et al. · 2023

Diet and Physical Activity in Adult Dominant Polycystic Kidney Disease: A Review of the Literature Open

Irene Capelli, Sarah Lerario, Valeria Aiello, Michele Provenzano, Roberta Di Costanzo , et al. · 2023

Autosomal polycystic kidney disease is the most common inherited kidney disease determining 5% of all end-stage kidney disease. The only therapy approved for this condition is Tolvaptan, which, with its aquaretic effect, has a strong effec…

Safety and Efficacy of Vedolizumab in Kidney Transplant Recipients With Crohn’s Disease Open

Marco Busutti, Olga Baraldi, Clara Valentina Porcu, Gianluca Samele, Anita Campus , et al. · 2023

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Rare Single Nucleotide and Copy Number Variants and the Etiology of Congenital Obstructive Uropathy: Implications for Genetic Diagnosis Open

Dina Ahram, Tze Y. Lim, Juntao Ke, Gina Jin, Miguel Verbitsky , et al. · 2023

Significance Statement Congenital obstructive uropathy (COU) is a prevalent human developmental defect with highly heterogeneous clinical presentations and outcomes. Genetics may refine diagnosis, prognosis, and treatment, but the genomic …

Early Light Chains Removal and Albumin Levels with a Double Filter-Based Extracorporeal Treatment for Acute Myeloma Kidney Open

Gabriele Donati, Fulvia Zappulo, Elisa Maietti, Anna Scrivo, Lorenzo Gasperoni , et al. · 2022

Renal impairment in Multiple Myeloma (MM) represents one of the most important factors that influences patient survival. In fact, before the introduction of modern chemotherapy, less than 25% of patients with acute kidney injury (AKI) and …

POS-001 A NOVEL CFHR5 COPY NUMBER VARIATION ASSOCIATED WITH POST-PARTUM ATYPICAL HUS SUPERIMPOSED TO HELLP SYNDROME Open

Rossella Piras, Marco Alberti, Elena Bresin, Olga Baraldi, Gaetano La Manna , et al. · 2022

IntroductionPregnancy and postpartum are triggers for various forms of thrombotic microangiopathy (TMA), a lesion characterized by endothelial injury and thrombosis in the microcirculation of various organs. These forms include thrombotic …

The risks associated with percutaneous native kidney biopsies: a prospective study Open

Simeone Andrulli, Michele Rossini, Giuseppe Gigliotti, Gaetano La Manna, Sandro Feriozzi , et al. · 2022

Background The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quanti…

Everolimus-associated alveolar hemorrage relapse after drug discontinuation in a kidney transplant recipient Open

Marco Busutti, Alessandra Cingolani, Filippo Natali, Maria Mattiotti, Valeria Grandinetti , et al. · 2022

The Relationship between Timing of Pretransplant Kidney Biopsy, Graft Loss, and Survival in Kidney Transplantation: An Italian Cohort Study Open

Federica Odaldi, Matteo Serenari, Giorgia Comai, Gaetano La Manna, Raffaele Bova , et al. · 2021

Introduction: Kidney biopsy is performed to assess if an extended criteria graft can be used for transplantation. It may be performed before or after cross-clamping during organ procurement. This study aims to evaluate whethe…

Renal involvement in sarcoidosis: histological patterns and prognosis, an Italian survey. Open

Francesco Rastelli, Ivano Baragetti, Laura Buzzi, Francesca Ferrario, Luisa Benozzi , et al. · 2021

sGIN-AKI-patients with no complete recovery at 1°line steroid should be treated with other immunosuppressive to avoid CKD, in particular if males with subacute onset and III stage-not hypercalcaemic AKI.

The Relationship Between Timing of Pre-Transplant Kidney Biopsy, Graft Loss, and Survival in Kidney Transplantation: An Italian Cohort Study. Open

Federica Odaldi, Matteo Serenari, Giorgia Comai, Gaetano La Manna, Raffaele Bova , et al. · 2020

Kidney biopsy is performed to assess if an extended criteria graft can be used for transplantation. It may be performed before or after cross-clamping during organ procurement. This study aims to evaluate whether the timing of biopsy may m…

New mineralocorticoid receptor antagonists: update on their use in chronic kidney disease and heart failure Open

Irene Capelli, Lorenzo Gasperoni, Marco Ruggeri, Gabriele Donati, Olga Baraldi , et al. · 2019

Preliminary experience of sequential use of normothermic and hypothermic oxygenated perfusion for donation after circulatory death kidney with warm ischemia time over the conventional criteria - a retrospective and observational study Open

Matteo Ravaioli, Vanessa De Pace, Giorgia Comai, Irene Capelli, Olga Baraldi , et al. · 2018

Donation after circulatory death (DCD) is a potential source of reducing organ demand. In Italy, DCD requires a 20-min no-touch period that prolongs warm ischemia and increases delayed graft function (DGF) risk and graft loss. We report he…

Erratum Open

Mauro Ursino, Irene Capelli, Olga Baraldi, Gaetano La Manna, Gabriele Donati , et al. · 2018

Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review Open

Giorgia Comai, Olga Baraldi, Vania Cuna, Valeria Corradetti, Maria Cappuccilli , et al. · 2018

Tubulo-interstitial nephritis (TIN) in patients affected by inflammatory bowel disease, both ulcerative colitis and Crohn’s disease, is usually considered as drug-associated to aminosalicylate. We report a rare case of granulomatous active…

Increase in Serum Amylase and Resistive Index After Kidney Transplant Are Biomarkers of Delayed Graft Function Open

Giorgia Comai, Olga Baraldi, Vania Cuna, Valeria Corradetti, Andrea Angeletti , et al. · 2018

Patients with concomitant amylase increase >20% and RI>0.7 might require closer monitoring to diagnose DGF early and modify the therapeutic approach accordingly.

Title page / Table of contents Open

Mauro Ursino, Irene Capelli, Olga Baraldi, Gaetano La Manna, Gabriele Donati , et al. · 2018

Cabozantinib‐induced renal thrombotic microangiopathy Open

Gaetano La Manna, Olga Baraldi, Valeria Corradetti, Giorgia Comai · 2017

A 61-year-old woman, affected by medullary thyroid cancer with multiple metastases (lymph nodes, liver, pancreas) treated with surgical intervention, started cabozantinib therapy with a good response. After 3 years she developed oedema, pr…

Sodium Prescription in the Prevention of Intradialytic Hypotension: New Insights into an Old Concept Open

Gabriele Donati, Mauro Ursino, Alessandra Spazzoli, Nicolò Natali, Roberto Schillaci , et al. · 2017

Background: Sodium prescription in patients with intradialytic hypotension remains a challenge for the attending nephrologist, as it increases dialysate conductivity in hypotension-prone patients, thereby adding to dietary so…

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