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View article: Optimizing mucosal vaccination: Exploiting Lactobionic acid-modified chitosan for superior gene delivery systems
Optimizing mucosal vaccination: Exploiting Lactobionic acid-modified chitosan for superior gene delivery systems Open
The increasing prevalence of respiratory disorders highlights the urgent need for effective mucosal vaccines that elicit targeted immune responses at pathogen entry sites. However, the advancement of mucosal vaccines is limited by challeng…
View article: Yeast-Derived Glucan Particles: Biocompatibility, Efficacy, and Immunomodulatory Potential as Adjuvants and Delivery Systems
Yeast-Derived Glucan Particles: Biocompatibility, Efficacy, and Immunomodulatory Potential as Adjuvants and Delivery Systems Open
Background/Objectives: Glucan particles (GPs), derived from Saccharomyces cerevisiae yeast, possess unique biomedical properties. Nevertheless, it is imperative that a comprehensive risk assessment is conducted during pre-clinical developm…
View article: Immunohistochemical Profiling of Immune Checkpoints in Chronic Hepatitis B Liver Tissue
Immunohistochemical Profiling of Immune Checkpoints in Chronic Hepatitis B Liver Tissue Open
Chronic hepatitis B (CHB) remains a significant global health concern due to complications like cirrhosis and liver cancer. Immune cell exhaustion, characterized by increased suppressive molecules and inhibitory receptors, represents a cri…
View article: Exploring TLR agonists as adjuvants for COVID-19 oral vaccines
Exploring TLR agonists as adjuvants for COVID-19 oral vaccines Open
The COVID-19 pandemic underscored the importance of advancing technologies that enable the rapid development and distribution of more effective vaccines when required. Since SARS-CoV-2 enters the body through the nasal mucosa, optimising t…
View article: Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells
Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells Open
In Hepatitis B patients, the virus targets liver cells, leading to inflammation and liver damage, which can result in severe complications such as liver failure, cirrhosis, and liver cancer. Therapeutic options for liver disease are curren…
View article: Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors
Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors Open
Background/Objectives: Nasal vaccines are a promising strategy for enhancing mucosal immune responses and preventing diseases at mucosal sites by stimulating the secretion of secretory IgA, which is crucial for early pathogen neutralizatio…
View article: Cell wall nanoparticles from hyphae of <i>Alternaria infectoria</i> grown with caspofungin, nikkomycin, or pyroquilon trigger different activation profiles in macrophages
Cell wall nanoparticles from hyphae of <i>Alternaria infectoria</i> grown with caspofungin, nikkomycin, or pyroquilon trigger different activation profiles in macrophages Open
Alternaria infectoria causes opportunistic human infections and is a source of allergens leading to respiratory allergies. In this work, we prepared cell wall nanoparticles (CWNPs) as a novel approach to study macrophage immunomodulation b…
View article: Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression
Insights into Immune Exhaustion in Chronic Hepatitis B: A Review of Checkpoint Receptor Expression Open
Hepatitis B, caused by the hepatitis B virus (HBV), often progresses to chronic infection, leading to severe complications, such as cirrhosis, liver failure, and hepatocellular carcinoma. Chronic HBV infection is characterized by a complex…
View article: Exploring the immunomodulatory properties of glucan particles in human primary cells
Exploring the immunomodulatory properties of glucan particles in human primary cells Open
The immunomodulatory properties of β-glucans have sparked interest among various medical fields. As vaccine adjuvants, glucan particles offer additional advantages as antigen delivery systems. This study reported the immunomodulatory prope…
View article: Unraveling the potential of Giardia extracellular vesicles as a vaccine candidat
Unraveling the potential of Giardia extracellular vesicles as a vaccine candidat Open
In this study, we investigated the role of Giardia EVs in cellular communication and their potential as vaccine candidates. Our findings revealed that Giardia EVs activate pro-inflammatory signalling cascades, including SAPK/JNK and ERK1/E…
View article: Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies
Endotoxin contamination of nanoparticle formulations: A concern in vaccine adjuvant mechanistic studies Open
The increasing awareness of endotoxin contamination has raised important questions during the study of the mechanism of action of the vaccine adjuvants. The endotoxins or lipopolysaccharides (LPS) can contaminate vaccine formulations contr…
View article: Synthetic and Natural Polymeric Drug Delivery Systems - A Comprehensive Overview of Polycaprolactone and Glucan Particles
Synthetic and Natural Polymeric Drug Delivery Systems - A Comprehensive Overview of Polycaprolactone and Glucan Particles Open
The small size and large surface area of nano and microparticles are interesting properties for drug delivery, hypothetically capable of overcoming some limitations of conventional therapeutic medicine and diagnostic agents. Although their…
View article: The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute
The Effect of Curcumin-Loaded Glucan Nanoparticles on Immune Cells: Size as a Critical Quality Attribute Open
Curcumin is known for its multiple health benefits, largely due to its antioxidant and anti-inflammatory properties. It has been extensively studied as a therapeutic agent, however, it does not have good clinical efficacy due to its poor w…
View article: Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-by-Design Concepts
Editorial: Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-by-Design Concepts Open
Horizon 2020 framework program of the European Union, ProSafe Joint Transnational Call 2016, and from the CTI (1.1.2018 Innosuisse) under grant agreement number 19267.1 PFNM-NM.
View article: A Methodological Safe-by-Design Approach for the Development of Nanomedicines
A Methodological Safe-by-Design Approach for the Development of Nanomedicines Open
Safe-by-Design (SbD) concepts foresee the risk identification and reduction as well as uncertainties regarding human health and environmental safety in early stages of product development. The EU's NANoREG project and further on the H2020 …
View article: How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept Open
Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization o…
View article: Safe-by-Designof Glucan Nanoparticles: Size MattersWhen Assessing the Immunotoxicity
Safe-by-Designof Glucan Nanoparticles: Size MattersWhen Assessing the Immunotoxicity Open
Glucan (from Alcaligenes\nfaecalis) is a polymer\ncomposed of β-1,3-linked glucose residues, and it has been addressed\nin different medical fields, namely in nanotechnology, as a vaccine\nor a drug delivery system. However, due to their s…
View article: Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility
Chitosan Nanoparticles: Shedding Light on Immunotoxicity and Hemocompatibility Open
Nanoparticles (NPs) assumed an important role in the area of drug delivery. Despite the number of studies including NPs are growing over the last years, their side effects on the immune system are often ignored or omitted. One of the most …
View article: Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model
Oral treatment with T6-loaded yeast cell wall particles reduces the parasitemia in murine visceral leishmaniasis model Open
Yeast cell wall particles isolated from Saccharomyces cerevisiae ( sc YCWPs) have a rich constitution of β-glucan derived from the cell wall. After removing intracellular contents, β-glucan molecules are readily recognized by dectin-1 rece…
View article: Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far
Hazard Assessment of Polymeric Nanobiomaterials for Drug Delivery: What Can We Learn From Literature So Far Open
The physicochemical properties of nanobiomaterials, such as their small size and high surface area ratio, make them attractive, novel drug-carriers, with increased cellular interaction and increased permeation through several biological ba…
View article: Activity and Cell-Death Pathway in Leishmania infantum Induced by Sugiol: Vectorization Using Yeast Cell Wall Particles Obtained From Saccharomyces cerevisiae
Activity and Cell-Death Pathway in Leishmania infantum Induced by Sugiol: Vectorization Using Yeast Cell Wall Particles Obtained From Saccharomyces cerevisiae Open
Visceral leishmaniasis, caused by Leishmania infantum, is a neglected tropical disease, to which efforts in the innovation of effective and affordable treatments remain limited, despite the rising incidence in several regions of the world.…
View article: Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases Its Immunotoxicity
Poly(D,L-Lactic Acid) Nanoparticle Size Reduction Increases Its Immunotoxicity Open
Polylactic acid (PLA), a biodegradable and biocompatible polymer produced from renewable resources, has been widely used as a nanoparticulate platform for antigen and drug delivery. Despite generally regarded as safe, its immunotoxicologic…
View article: Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies
Easy and effective method to generate endotoxin-free chitosan particles for immunotoxicology and immunopharmacology studies Open
Objectives The cationic biopolymer chitosan (CH) has emerged as a promising candidate adjuvant due to its safety profile and immunostimulatory properties. The presence of endotoxin contamination in biomaterials is generally underappreciate…
View article: Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant
Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant Open
Current vaccine research is mostly based on subunit antigens. Despite the better toxicity profile of these antigens they are often poorly immunogenic, so adjuvant association has been explored as a strategy to obtain a potent vaccine formu…