Olga G. Jaime
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View article: Antisense oligonucleotides targeting valosin‐containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy
Antisense oligonucleotides targeting valosin‐containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy Open
Background Valosin‐containing protein (VCP) related disease, also known as multisystem proteinopathy 1 (MSP1), is an autosomal dominant disease caused by gain‐of‐function pathogenic variants of the VCP gene. The disease presents with varia…
View article: Antisense oligonucleotides targeting Valosin-containing protein improve muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy
Antisense oligonucleotides targeting Valosin-containing protein improve muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy Open
Valosin-containing protein (VCP) related disease, also known as multisystem proteinopathy 1 (MSP1), is an autosomal dominant disease caused by gain-of-function pathogenic variants of the VCP gene. The disease is associated with inclusion b…
View article: Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model
Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model Open
View article: Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model
Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model Open
Despite the major roles of choroid plexus epithelial cells (CPECs) in brain homeostasis and repair, their developmental lineage and diversity remain undefined. In simplified differentiations from human pluripotent stem cells, derived CPECs…
View article: SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs
SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs Open
The earliest skeletal muscle progenitor cells (SMPCs) derived from human pluripotent stem cells (hPSCs) are often identified by factors expressed by a diverse number of progenitors. An early transcriptional checkpoint that defines myogenic…
View article: Mosquito cryptochromes expressed in Drosophila confer species-specific behavioral light responses
Mosquito cryptochromes expressed in Drosophila confer species-specific behavioral light responses Open