Olga Kerber
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View article: Zn(II) to Ag(I) Swap in Rad50 Zinc Hook Domain Leads to Interprotein Complex Disruption through the Formation of Highly Stable Ag<i><sub>x</sub></i>(Cys)<i><sub>y</sub></i> Cores
Zn(II) to Ag(I) Swap in Rad50 Zinc Hook Domain Leads to Interprotein Complex Disruption through the Formation of Highly Stable Ag<i><sub>x</sub></i>(Cys)<i><sub>y</sub></i> Cores Open
The widespread application of silver nanoparticles in medicinal and daily life products increases the exposure to Ag(I) of thiol-rich biological environments, which help control the cellular metallome. A displacement of native metal cofact…
View article: An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH
An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH Open
Invited for the cover of this issue is the group of Artur Krężel at the University of Wrocław in collaboration with Lars Hemmingsen at The University of Copenhagen and Eva Freisinger at the University of Zürich. The image depicts the outco…
View article: Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022)
Front Cover: An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH (Chem. Eur. J. 66/2022) Open
HgII interacting with a naturally ZnII-containing Rad50 protein interface yields HgS4 species, the strongest metal–protein interaction known to date. It also introduces the novel manifestation of HgII mechanism of prokaryotic and eukaryoti…
View article: An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH
An Extremely Stable Interprotein Tetrahedral Hg(Cys)<sub>4</sub> Core Forms in the Zinc Hook Domain of Rad50 Protein at Physiological pH Open
In nature, thiolate‐based systems are the primary targets of divalent mercury (Hg II ) toxicity. The formation of Hg(Cys) x cores in catalytic and structural protein centers mediates mercury's toxic effects and ultimately leads to cellular…
View article: 2',3'-cAMP treatment mimics the stress molecular response in Arabidopsis thaliana.
2',3'-cAMP treatment mimics the stress molecular response in Arabidopsis thaliana. Open
The role of the RNA degradation product 2',3'-cyclic adenosine monophosphate (2',3'-cAMP) is poorly understood. Recent studies have identified 2',3'-cAMP in plant material and determined its role in stress signaling. The level of 2',3'-cAM…
View article: 2′,3′-cAMP treatment mimics the stress molecular response in <i>Arabidopsis thaliana</i>
2′,3′-cAMP treatment mimics the stress molecular response in <i>Arabidopsis thaliana</i> Open
The role of the RNA degradation product 2′,3′-cyclic adenosine monophosphate (2′,3′-cAMP) is poorly understood. Recent studies have identified 2′,3′-cAMP in plant material and determined its role in stress signaling. The level of 2′,3′-cAM…
View article: 2’,3’-cAMP treatment mimics stress molecular response in<i>Arabidopsis thaliana</i>
2’,3’-cAMP treatment mimics stress molecular response in<i>Arabidopsis thaliana</i> Open
The role of the RNA degradation product 2’,3’-cyclic adenosine monophosphate (2’,3’-cAMP) is poorly understood. Recent studies have identified 2’,3’-cAMP in plant material and determined its role in stress signaling. The level of 2’,3’-cAM…
View article: Metal Exchange in the Interprotein Zn<sup>II</sup>‐Binding Site of the Rad50 Hook Domain: Structural Insights into Cd<sup>II</sup>‐Induced DNA‐Repair Inhibition
Metal Exchange in the Interprotein Zn<sup>II</sup>‐Binding Site of the Rad50 Hook Domain: Structural Insights into Cd<sup>II</sup>‐Induced DNA‐Repair Inhibition Open
Cd II is a major genotoxic agent that readily displaces Zn II in a multitude of zinc proteins, abrogates redox homeostasis, and deregulates cellular metalloproteome. To date, this displacement has been described mostly for cysteine(Cys)‐ri…
View article: Structural zinc binding sites shaped for greater works: Structure-function relations in classical zinc finger, hook and clasp domains
Structural zinc binding sites shaped for greater works: Structure-function relations in classical zinc finger, hook and clasp domains Open
Metal ions are essential elements present in biological systems able to facilitate many cellular processes including proliferation, signaling, DNA synthesis and repair. Zinc ion (Zn(II)) is an important cofactor for numerous biochemical re…
View article: Interaction of 2',3'-cAMP with Rbp47b plays a role in stress granule formation
Interaction of 2',3'-cAMP with Rbp47b plays a role in stress granule formation Open
29,39-cAMP is an intriguing small molecule that is conserved among different kingdoms. 29,39-cAMP is presumably produced during RNA degradation, with increased cellular levels observed especially under stress conditions. Previously, we obs…