Olga Spadaro
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View article: Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity Open
The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mi…
View article: RETRACTED: Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy
RETRACTED: Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy Open
The authors have requested that this preprint be removed from Research Square.
View article: Caloric restriction in humans reveals immunometabolic regulators of health span
Caloric restriction in humans reveals immunometabolic regulators of health span Open
The extension of life span driven by 40% caloric restriction (CR) in rodents causes trade-offs in growth, reproduction, and immune defense that make it difficult to identify therapeutically relevant CR-mimetic targets. We report that about…
View article: Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis
Aging induces Nlrp3 inflammasome dependent adipose B cell expansion to impair metabolic homeostasis Open
Summary Visceral adiposity in elderly is associated with alterations in adipose tissue immune cells leading to inflammation and metabolic dysfunction. The Nlrp3 inflammasome is a critical regulator of macrophage activation, inflammation, a…
View article: SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model
SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model Open
Anorexia Nervosa (AN) is an eating disorder characterized by severe hypophagia, high levels of physical activity, harsh weight loss and an intense fear of weight gain. It has the highest mortality rate among psychiatric illnesses and, due …
View article: Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms
Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms Open
Significance Cross-sectional studies have demonstrated that hypothyroidism is an independent risk factor for nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of hypothyroidism-induced NAFLD has yet to be characterized. H…
View article: Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence Open
The hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion of effector memory, and loss of naive T lymphocytes due in part to systemic activation of innate immune sensor NLRP3 inflammasome in myeloid lineag…