Olimpia E. Curran
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View article: Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival Open
Better understanding of GBM signalling networks in-vivo would help develop more physiologically relevant ex vivo models to support therapeutic discovery. A “functional proteomics” screen was undertaken to measure the specific activity of a…
View article: MYD88 L265P mutation in primary central nervous system lymphoma is associated with better survival: A single-center experience
MYD88 L265P mutation in primary central nervous system lymphoma is associated with better survival: A single-center experience Open
Background The myeloid differentiation primary response gene (MYD88) mutation in primary central nervous system lymphomas (PCNSL) may be associated with unfavorable prognosis; however, current evidence remains limited. We aimed to characte…
View article: Species differences in the cerebellar distribution of six members of the Kv1 channel subfamily
Species differences in the cerebellar distribution of six members of the Kv1 channel subfamily Open
Comprehensive studies on the distribution of the Kv1 subfamily have been performed in rat (Chung et al., 2001) and gerbil (Chung et al., 2005), but not in mouse or human. We hypothesized that species differences may exist in the localizati…
View article: MYD88 L265P mutation in primary central nervous system lymphoma is associated with better survival: A single centre experience
MYD88 L265P mutation in primary central nervous system lymphoma is associated with better survival: A single centre experience Open
Background The Myeloid differentiation primary response gene ( MYD88 ) mutation in primary central nervous system lymphomas (PCNSL) may be associated with unfavourable prognosis, however the evidence remains limited. We aimed to comprehens…
View article: A single‐synapse resolution survey of PSD95‐positive synapses in twenty human brain regions
A single‐synapse resolution survey of PSD95‐positive synapses in twenty human brain regions Open
Mapping the molecular composition of individual excitatory synapses across the mouse brain reveals high synapse diversity with each brain region showing a distinct composition of synapse types. As a first step towards systematic mapping of…
View article: The human and mouse synaptome architecture of excitatory synapses show conserved features
The human and mouse synaptome architecture of excitatory synapses show conserved features Open
Large-scale mapping of the location of synapses and their molecular properties in the mouse has shown that diverse synapse types are spatially distributed across the brain. The diversity of synapses is known as the synaptome and the spatia…
View article: Rare pituitary Perivascular Epithelioid Cell tumour (PEComa)
Rare pituitary Perivascular Epithelioid Cell tumour (PEComa) Open
A 63 year old lady presented with general weakness and 4 months progressive visual disturbance. She has a family history of Birt-Hogg-Dube syndrome. Examination revealed bi-temporal hemianopia. MRI imaging showed a pituitary lesion with su…