Olin Janssen
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View article: Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum Open
This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that…
View article: Novel perspectives from existing data on early Alzheimer’s disease pathology and dementia care use
Novel perspectives from existing data on early Alzheimer’s disease pathology and dementia care use Open
Alzheimer’s disease (AD) has a long disease duration and a progressive course. To stop or slow down cognitive decline as early as possible, intervention studies are increasingly focusing on the earliest stage of the disease. To evaluate th…
View article: Characteristics of subjective cognitive decline associated with amyloid positivity
Characteristics of subjective cognitive decline associated with amyloid positivity Open
Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the as…
View article: Predictors of preclinical Alzheimer’s disease in persons with subjective cognitive decline
Predictors of preclinical Alzheimer’s disease in persons with subjective cognitive decline Open
Background To identify at‐risk individuals that will likely benefit from disease‐modifying treatment and improve selection for clinical trials, the role of unobjectified cognitive complaints (subjective cognitive decline, SCD) in preclinic…
View article: Duration of Care Trajectories in Persons With Dementia Differs According to Demographic and Clinical Characteristics
Duration of Care Trajectories in Persons With Dementia Differs According to Demographic and Clinical Characteristics Open
View article: Time from diagnosis to institutionalization and death in people with dementia
Time from diagnosis to institutionalization and death in people with dementia Open
Introduction Reliable estimates of time from diagnosis until institutionalization and death in people with dementia from routine nationally representative databases are lacking. Methods We selected 9230 people with dementia and 24,624 matc…
View article: What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health‐care professionals? A systematic review
What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health‐care professionals? A systematic review Open
Introduction Clinical trials involving patients with Alzheimer's disease (AD) continue to try to identify disease‐modifying treatments. Although trials are designed to meet regulatory and registration requirements, many do not measure outc…
View article: P3‐585: COGNITIVE RESERVE MODULATES THE ASSOCIATION OF CEREBRAL AMYLOID PATHOLOGY WITH COGNITIVE PERFORMANCE IN PERSONS WITH ALZHEIMER'S DISEASE DEMENTIA
P3‐585: COGNITIVE RESERVE MODULATES THE ASSOCIATION OF CEREBRAL AMYLOID PATHOLOGY WITH COGNITIVE PERFORMANCE IN PERSONS WITH ALZHEIMER'S DISEASE DEMENTIA Open
The relationship between amyloid-ß deposition and the subsequent clinical expression of Alzheimer's disease (AD)-type dementia is found to be moderated by cognitive reserve. We here aim to investigate whether the protective effect of cogni…