Oliver Baretella
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View article: Target trial emulation of statin discontinuation in multimorbid older adults with polypharmacy
Target trial emulation of statin discontinuation in multimorbid older adults with polypharmacy Open
Background The benefit of statins in multimorbid older adults is controversial. Prior observational studies evaluating statin discontinuation in older adults were retrospective cohorts, did not focus on multimorbidity, or lacked adjustment…
View article: Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex
Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex Open
Context Subclinical thyroid dysfunction (ScTD), comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper), has been associated with increased risk for cardiovascular events. Objective To assess associations bet…
View article: Statin therapy in multimorbid older patients with polypharmacy- a cross-sectional analysis of the Swiss OPERAM trial population
Statin therapy in multimorbid older patients with polypharmacy- a cross-sectional analysis of the Swiss OPERAM trial population Open
Background Statin therapy in multimorbid older individuals with polypharmacy is controversial, particularly in primary prevention of cardiovascular disease. Thereby, physicians must weigh potential benefits against potential side effects, …
View article: Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease
Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease Open
Objective Atherosclerosis expression varies across not only coronary, cerebrovascular, and peripheral arteries but also within the peripheral vascular tree. The underlying pathomechanisms of distinct atherosclerosis phenotypes in lower ext…
View article: Overtreatment and associated risk factors among multimorbid older patients with diabetes
Overtreatment and associated risk factors among multimorbid older patients with diabetes Open
Background In multimorbid older patients with type 2 diabetes mellitus (T2DM), the intensity of glucose‐lowering medication (GLM) should be focused on attaining a suitable level of glycated hemoglobin (HbA 1c ) while avoiding side effects.…
View article: Association between diabetes overtreatment in older multimorbid patients and clinical outcomes: an ancillary European multicentre study
Association between diabetes overtreatment in older multimorbid patients and clinical outcomes: an ancillary European multicentre study Open
Background Diabetes overtreatment is a frequent and severe issue in multimorbid older patients with type 2 diabetes (T2D). Objective This study aimed at assessing the association between diabetes overtreatment and 1-year functional decline…
View article: No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials
No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials Open
Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin le…
View article: Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients.
Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients. Open
BACKGROUND Older adults with chronic conditions are at high risk of complications from influenza and pneumococcal infections. Evidence about factors associated with influenza and pneumococcal vaccination among older multimorbid persons in …
View article: Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients
Cross-sectional study on the prevalence of influenza and pneumococcal vaccination and its association with health conditions and risk factors among hospitalized multimorbid older patients Open
Background Older adults with chronic conditions are at high risk of complications from influenza and pneumococcal infections. Evidence about factors associated with influenza and pneumococcal vaccination among older multimorbid persons in …
View article: Biomarkers, Clinical Variables, and the CHA2DS2-VASc Score to Detect Silent Brain Infarcts in Atrial Fibrillation Patients
Biomarkers, Clinical Variables, and the CHA2DS2-VASc Score to Detect Silent Brain Infarcts in Atrial Fibrillation Patients Open
View article: Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial
Optimizing Therapy to Prevent Avoidable Hospital Admissions in Multimorbid Older Adults (OPERAM): cluster randomised controlled trial Open
Objective To examine the effect of optimising drug treatment on drug related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters of…
View article: The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation
The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation Open
The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) rema…
View article: Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation
Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation Open
ClinicalTrials.gov, no. NCT02105844.
View article: Association of Sex and Cardiovascular Risk Factors with Atherosclerosis Distribution Pattern in Lower Extremity Peripheral Artery Disease
Association of Sex and Cardiovascular Risk Factors with Atherosclerosis Distribution Pattern in Lower Extremity Peripheral Artery Disease Open
View article: The Admit-AF risk score: a clinical risk score for predicting hospital admissions in patients with atrial fibrillation
The Admit-AF risk score: a clinical risk score for predicting hospital admissions in patients with atrial fibrillation Open
Background Patients with atrial fibrillation (AF) have a high risk of hospital admissions, but there is no validated prediction tool to identify those at highest risk. Purpose To develop and externally validate a risk score for all-cause h…
View article: Prognostic significance of present atrial fibrillation on a single office electrocardiogram in patients with atrial fibrillation
Prognostic significance of present atrial fibrillation on a single office electrocardiogram in patients with atrial fibrillation Open
Background Evidence for the association of atrial fibrillation (AF) present on the ECG and cardiovascular outcomes in AF patients is limited. Objective To investigate the prognostic significance of AF on a single surface ECG for cardiovasc…
View article: Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019)
Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019) Open
View article: P3712The omega-3 fatty acid eicosapentaenoic acid (EPA) is inversely associated with ischemic brain infarcts in elderly patients with atrial fibrillation
P3712The omega-3 fatty acid eicosapentaenoic acid (EPA) is inversely associated with ischemic brain infarcts in elderly patients with atrial fibrillation Open
Background The association of individual omega-3 fatty acids (n-3 FAs) with ischemic stroke remains unclear. Experimental data strongly suggest that n-3 FAs reduce ischemic stroke due to their anti-thrombotic and anti-inflammatory properti…
View article: Supplementary Material for: No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss
Supplementary Material for: No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss Open
Background: Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes. Methods: Mice with const…
View article: Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors
Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors Open
View article: Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice
Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice Open
View article: Prostanoid-mediated contractions in rodent conduit and renal arteries
Prostanoid-mediated contractions in rodent conduit and renal arteries Open