Oliver Borsch
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View article: Transplanted human cones incorporate into the retina and function in a murine cone degeneration model.
Transplanted human cones incorporate into the retina and function in a murine cone degeneration model. Open
Once human photoreceptors die, they do not regenerate, thus, photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation, and synaptic co…
View article: Transplanted human cones incorporate into the retina and function in a murine cone degeneration model
Transplanted human cones incorporate into the retina and function in a murine cone degeneration model Open
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View article: Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections
Evidence for endogenous exchange of cytoplasmic material between a subset of cone and rod photoreceptors within the adult mammalian retina via direct cell-cell connections Open
Photoreceptor cell transplantation into the mouse retina has been shown to result in the transfer of cytoplasmic material between donor and host photoreceptors. Recently it has been found that this inter-photoreceptor material transfer pro…
View article: Label-free imaging flow cytometry for analysis and sorting of enzymatically dissociated tissues
Label-free imaging flow cytometry for analysis and sorting of enzymatically dissociated tissues Open
Biomedical research relies on identification and isolation of specific cell types using molecular biomarkers and sorting methods such as fluorescence or magnetic activated cell sorting. Labelling processes potentially alter the cells’ prop…
View article: Extensive incorporation, polarisation and improved maturation of transplanted human cones in a murine cone degeneration model
Extensive incorporation, polarisation and improved maturation of transplanted human cones in a murine cone degeneration model Open
Summary Once human photoreceptors die, they do not regenerate, thus photoreceptor transplantation has emerged as a potential treatment approach for blinding diseases. Improvements in transplant organization, donor cell maturation and synap…
View article: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues
Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues Open
Biomedical research often relies on identification and isolation of specific cell types using molecular biomarkers and sorting methods such as fluorescence or magnetic activated cell sorting. Labelling processes potentially alter the cells…
View article: Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues
Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues Open
Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues. This repository contains data to reproduce each figure contained in the manuscript "Label-free imaging flo…
View article: Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues
Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues Open
Datasets corresponding to publication: Label-free imaging flow cytometry: analysis and sorting of enzymatically dissociated tissues. This repository contains data to reproduce each figure contained in the manuscript "Label-free imaging flo…
View article: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Rod photoreceptors of nocturnal mammals display a striking inversion of nuclear architecture, which has been proposed as an evolutionary adaptation to dark environments. However, the nature of visual benefits and the underlying mechanisms …
View article: Author response: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Author response: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Rod photoreceptors of nocturnal mammals di…
View article: Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice
Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice Open
Rod photoreceptors of nocturnal mammals display a striking inversion of nuclear architecture, which has been proposed as an evolutionary adaptation to dark environments. However, the nature of visual benefits and underlying mechanisms rema…
View article: Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives Open
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal degenerative diseases such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP) result in a permanent loss of the light-sensing photore…
View article: Rebuilding the Missing Part—A Review on Photoreceptor Transplantation
Rebuilding the Missing Part—A Review on Photoreceptor Transplantation Open
Vision represents one of the main senses for humans to interact with their environment. Our sight relies on the presence of fully functional light sensitive cells - rod and cone photoreceptors - allowing us to see under dim (rods) and brig…
View article: Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange Open
Pre-clinical studies provided evidence for successful photoreceptor cell replacement therapy. Migration and integration of donor photoreceptors into the retina has been proposed as the underlying mechanism for restored visual function. Her…
View article: Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy
Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy Open
Comparison of photoreceptor grafts in preclinical models with incomplete or complete photoreceptor loss, showed differential transplant success with effective and impaired integration, respectively. Thus, Cpfl1/Rho-/- mice represent a pote…
View article: In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors
In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors Open
Point mutations in peripherin-2 (PRPH2) are associated with severe retinal degenerative disorders affecting rod and/or cone photoreceptors. Various disease-causing mutations have been identified, but the exact contribution of a given mutat…