Oliver Devine
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View article: Multiple outcomes of the germline <scp>p16<sup>INK4a</sup></scp> mutation affecting senescence and immunity in human skin
Multiple outcomes of the germline <span>p16<sup>INK4a</sup></span> mutation affecting senescence and immunity in human skin Open
The integrated behaviour of multiple senescent cell types within a single human tissue leading to the development of malignancy is unclear. Patients with Familial Melanoma Syndrome (FMS) have heterozygous germline defects in the CDKN2A gen…
View article: An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory Open
View article: Medical leadership training varies substantially between UK medical schools: Report of the leadership in undergraduate medical education national survey (LUMENS)
Medical leadership training varies substantially between UK medical schools: Report of the leadership in undergraduate medical education national survey (LUMENS) Open
Doctors are increasingly expected to demonstrate medical leadership and management (MLM) skills. The Faculty of Medical Leadership and Management (FMLM) has published an indicative undergraduate curriculum to guide the development of MLM c…
View article: Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging Open
View article: Intercellular telomere transfer extends T cell lifespan
Intercellular telomere transfer extends T cell lifespan Open
The common view is that T-lymphocytes activate telomerase, a DNA polymerase that extends telomeres at chromosome ends, to delay senescence. We show that independently of telomerase, T cells elongate telomeres by acquiring telomere vesicles…
View article: Adjusting to Disrupted Assessments, Placements and Teaching (ADAPT): a snapshot of the early response by UK medical schools to COVID-19
Adjusting to Disrupted Assessments, Placements and Teaching (ADAPT): a snapshot of the early response by UK medical schools to COVID-19 Open
Background Medical school assessments, clinical placements and teaching have been disrupted by the COVID-19 pandemic. The ADAPT consortium was formed to document and analyse the effects of the pandemic on medical education in the United Ki…
View article: The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning
The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning Open
View article: Publisher Correction: Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Publisher Correction: Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly Open
View article: Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly Open
View article: Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing
Monocyte-derived Prostaglandin E2 inhibits antigen-specific cutaneous immunity during ageing Open
Ageing results in a decline in immune function. We showed previously that healthy older humans (>65 years old) have reduced antigen-specific cutaneous immunity to varicella zoster virus (VZV) antigen challenge. This was associated with p38…
View article: Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8<sup>+</sup> T cells in human cutaneous leishmaniasis
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8<sup>+</sup> T cells in human cutaneous leishmaniasis Open
Summary Cytotoxic activity mediated by CD8 + T cells is the main signature of the immunopathogenesis of cutaneous leishmaniasis (CL). Here, we performed a broad evaluation of natural killer (NK) cell phenotypic and functional features duri…
View article: Additional file 1 of The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning
Additional file 1 of The Analysis of Teaching of Medical Schools (AToMS) survey: an analysis of 47,258 timetabled teaching events in 25 UK medical schools relating to timing, duration, teaching formats, teaching content, and problem-based learning Open
Additional file 1: Supplementary file 1. Data for Fig. 5 as Excel file.
View article: Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition Open
Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express the non-classical MH…
View article: CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age
CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age Open
Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with…
View article: Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis
Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis Open
Leishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a cell-mediated Th1 i…
View article: 83 How do medical students view leadership? A national curriculum analysis and survey
83 How do medical students view leadership? A national curriculum analysis and survey Open
This project, conducted by the FMLM Medical Student Group, was the first national analysis of UK medical students' access to medical leadership and management (MLM) teaching, within the undergraduate curriculum, and their opinions regardin…
View article: Pneumothorax secondary to pulmonary alveolar microlithiasis
Pneumothorax secondary to pulmonary alveolar microlithiasis Open
Key Clinical Message Pulmonary alveolar microlithiasis ( PAM ) is a rare impairment of pulmonary phosphate clearance that leads to gradual precipitation of intra‐alveolar calcium phosphate microliths. There is often a striking difference b…
View article: Colonic perforation by an intrathecal baclofen pump catheter causing delayed<i>Escherichia coli</i>meningitis
Colonic perforation by an intrathecal baclofen pump catheter causing delayed<i>Escherichia coli</i>meningitis Open
Intrathecal baclofen (ITB) delivery via an implanted pump is frequently used for the treatment of spasticity. This is an effective and safe neurosurgical and pharmacological intervention associated with an improvement in patient quality of…
View article: Unusual placement of intrathecal baclofen pumps: report of two cases
Unusual placement of intrathecal baclofen pumps: report of two cases Open
View article: Assessment at UK medical schools varies substantially in volume, type and intensity and correlates with postgraduate attainment
Assessment at UK medical schools varies substantially in volume, type and intensity and correlates with postgraduate attainment Open
There are substantial differences in the volume, format and intensity of undergraduate assessment between UK medical schools. These findings suggest a potential for differences in the reliability of detecting poorly performing students, or…