Oliver Dutton
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View article: Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data
Improving Inverse Folding models at Protein Stability Prediction without additional Training or Data Open
Deep learning protein sequence models have shown outstanding performance at de novo protein design and variant effect prediction. We substantially improve performance without further training or use of additional experimental data by intro…
View article: ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers
ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers Open
Intrinsically disordered proteins (IDPs) are important for a broad range of biological functions and are involved in many diseases. An understanding of intrinsic disorder is key to develop compounds that target IDPs. Experimental character…
View article: NeRFax: An efficient and scalable conversion from the internal representation to Cartesian space
NeRFax: An efficient and scalable conversion from the internal representation to Cartesian space Open
Motivation Accurate modelling of protein ensembles requires sampling of a large number of 3D conformations. A number of sampling approaches that use internal coordinates have been proposed, yet poor performance in the conversion from inter…
View article: ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers
ADOPT: intrinsic protein disorder prediction through deep bidirectional transformers Open
Intrinsically disordered proteins (IDP) are important for a broad range of biological functions and are involved in many diseases. An understanding of intrinsic disorder is key to develop compounds that target IDPs. Experimental characteri…
View article: Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains
Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains Open
Conformationally controlled flexible molecules are ideal for applications in medicine and materials, where shape matters but an ability to adapt to multiple and changing environments is often required. The conformation of flexible hydrocar…