Oliver E. Amin
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View article: Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality
Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality Open
IgG-based anti-cancer therapies have achieved promising clinical outcomes, but, especially for patients with solid tumors, response rates vary. IgE antibodies promote distinct immune responses compared to IgG and have shown anti-tumoral pr…
View article: Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS Open
The liver is bathed in bacterial products, including lipopolysaccharide transported from the intestinal portal vasculature, but maintains a state of tolerance that is exploited by persistent pathogens and tumours1-4. The cellular basis med…
View article: Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response Open
Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immun…
View article: Immune boosting by B.1.1.529 <b>(</b> Omicron) depends on previous SARS-CoV-2 exposure
Immune boosting by B.1.1.529 <b>(</b> Omicron) depends on previous SARS-CoV-2 exposure Open
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individ…
View article: NK cells limit therapeutic vaccine–induced CD8 <sup>+</sup> T cell immunity in a PD-L1–dependent manner
NK cells limit therapeutic vaccine–induced CD8 <sup>+</sup> T cell immunity in a PD-L1–dependent manner Open
A better understanding of mechanisms that regulate CD8 + T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers. We show here that NK cell depletion enh…
View article: The human liver microenvironment shapes the homing and function of CD4 <sup>+</sup> T-cell populations
The human liver microenvironment shapes the homing and function of CD4 <sup>+</sup> T-cell populations Open
Objective Tissue-resident memory T cells (T RM ) are vital immune sentinels that provide protective immunity. While hepatic CD8 + T RM have been well described, little is known about the location, phenotype and function of CD4 + T RM . Des…
View article: O06 Aminobisphosphonates enhance liver-resident gamma delta T cells for efficient targeting of hepatocellular carcinoma
O06 Aminobisphosphonates enhance liver-resident gamma delta T cells for efficient targeting of hepatocellular carcinoma Open
Background More effective immunotherapeutic strategies are urgently needed for hepatocellular carcinoma (HCC). Gamma delta (γδ) T-cells are attractive candidates for cancer immunotherapy due to their potent cytotoxicity, tissue localisatio…
View article: Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study Open
Barts Charity, Wellcome Trust, and National Institute of Health Research.
View article: Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 infection
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 infection Open
Individuals with likely exposure to the highly infectious SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T cells can contribute to the rapid clearan…
View article: Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose Open
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived infection with the virus was tested. A year after the pandemic was declared, vaccination of previously infec…
View article: Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators
Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators Open
Background and Aims GS‐9688 (selgantolimod) is a toll‐like receptor 8 agonist in clinical development for the treatment of chronic hepatitis B (CHB). Antiviral activity of GS‐9688 has previously been evaluated in vitro in HBV‐infected hepa…
View article: Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection Open
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after Uni…
View article: Healthcare workers with mild / asymptomatic SARS-CoV-2 infection show T cell responses and neutralising antibodies after the first wave
Healthcare workers with mild / asymptomatic SARS-CoV-2 infection show T cell responses and neutralising antibodies after the first wave Open
Studies of adaptive immunity to SARS-CoV-2 include characterisation of lethal, severe and mild cases 1-8 . Understanding how long immunity lasts in people who have had mild or asymptomatic infection is crucial. Healthcare worker (HCW) coho…
View article: The human liver microenvironment shapes the homing and function of CD4<sup>+</sup>T-cell populations
The human liver microenvironment shapes the homing and function of CD4<sup>+</sup>T-cell populations Open
Background & Aims Tissue-resident memory T cells (T RM ) are important immune sentinels that provide efficient in situ immunity. Liver-resident CD8 + T RM have been previously described, and contribute to viral control in persistent hepato…
View article: Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes
Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes Open
The human liver contains specialized subsets of mononuclear phagocytes (MNPs) and T cells, but whether these have definitive features of tissue residence (long-term retention, lack of egress) and/or can be replenished from the circulation …
View article: Circulating and intrahepatic antiviral B cells are defective in hepatitis B
Circulating and intrahepatic antiviral B cells are defective in hepatitis B Open
B cells are increasingly recognized as playing an important role in the ongoing control of hepatitis B virus (HBV). The development of antibodies against the viral surface antigen (HBV surface antigen [HBsAgs]) constitutes the hallmark of …