Oliver H. Weiergräber
YOU?
Author Swipe
View article: Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning Open
Developing macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource intensive and provide little control over binding mode. Despite progress in protein design, there are currently no r…
View article: Characterization of a C-methyltransferase from <i>Streptomyces griseoviridis</i> – crystal structure, mechanism, and substrate scope
Characterization of a C-methyltransferase from <i>Streptomyces griseoviridis</i> – crystal structure, mechanism, and substrate scope Open
This study elucidates the structure, catalytic mechanism, and substrate selectivity of the SAM-dependent methyltransferase from Streptomyces griseoviridis , which catalyses the synthesis of pyrroloindole motifs in tryptophan-based diketopi…
View article: Accurate<i>de novo</i>design of high-affinity protein binding macrocycles using deep learning
Accurate<i>de novo</i>design of high-affinity protein binding macrocycles using deep learning Open
The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite considerable progress in physics-based metho…
View article: Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP
Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP Open
We report the first structure-activity studies of arylidene-indolinone compound GW5074 which was reported as a ligand of autophagy-related protein LC3B. The literature has conflicting information on the binding affinity of this compound an…
View article: Highlighting the hidden: A tagging strategy for monitoring the association of GABARAP with microtubules in living cells
Highlighting the hidden: A tagging strategy for monitoring the association of GABARAP with microtubules in living cells Open
GABARAP, like other ATG8 proteins, is a ubiquitin-like modifier and its C-terminal lipid conjugation enables association with cellular membranes. To prevent interference with the lipidation process, N-terminal fluorescent protein (FP) tagg…
View article: Structure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity
Structure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity Open
Human C-C motif ligand 16 (CCL16) is a chemokine that is distinguished by a large cleavable C-terminal extension of unknown significance. Conflicting data have been reported concerning its tissue distribution and modulation of expression, …
View article: Correction: Freischem et al. Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules 2021, 11, 1057
Correction: Freischem et al. Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria. Biomolecules 2021, 11, 1057 Open
In the original article [...]
View article: Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses
Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses Open
View article: Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria
Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria Open
Novel antimicrobial strategies are urgently required because of the rising threat of multi drug resistant bacterial strains and the infections caused by them. Among the available target structures, the so-called penicillin binding proteins…
View article: Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein Open
Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate importa…
View article: A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations Open
Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurodevelopment and a prominent candidate protein in the pathology of major mental illness. DISC1 modulates a number of critical neuronal signalin…
View article: Correction: Corrigendum: Trading off stability against activity in extremophilic aldolases
Correction: Corrigendum: Trading off stability against activity in extremophilic aldolases Open
Scientific Reports 6: Article number: 17908; published online: 19 January 2016; updated: 11 November 2016
View article: Trading off stability against activity in extremophilic aldolases
Trading off stability against activity in extremophilic aldolases Open
View article: Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies
Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies Open
Understanding the deactivation mechanism of 2-deoxy- d -ribose-5-phosphate aldolase by its natural substrate leads to a single mutant showing complete acetaldehyde resistance.
View article: The mammalian autophagy initiator complex contains 2 HORMA domain proteins
The mammalian autophagy initiator complex contains 2 HORMA domain proteins Open
ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure o…