Oliver Kobler
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View article: Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion Open
Two evolutionary highly conserved functions of dopamine are to carry “teaching” signals during associative learning and to control movement. In mammals and humans these functions are generally thought to be produced by different population…
View article: Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion Open
Two evolutionary highly conserved functions of dopamine are to carry “teaching” signals during associative learning and to control movement. In mammals and humans these functions are generally thought to be produced by different population…
View article: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms Open
At many vertebrate synapses, presynaptic functions are tuned by expression of different Ca v 2 channels. Most invertebrate genomes contain only one Ca v 2 gene. The Drosophila Ca v 2 homolog, cacophony (cac), induces synaptic vesicle relea…
View article: Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion
Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion Open
Two evolutionary highly conserved functions of dopamine are to carry “teaching” signals during associative learning and to control movement. In mammals and humans these functions are generally thought to be produced by different population…
View article: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms Open
The multiplicity of neural circuits that accommodate the sheer infinite number of computations conducted by brains requires diverse synapse and neuron types. At many vertebrate synapses release probability and other aspects of presynaptic …
View article: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms Open
The multiplicity of neural circuits that accommodate the sheer infinite number of computations conducted by brains requires diverse synapse and neuron types. At the vertebrate presynaptic active zone functional diversity can be achieved by…
View article: Author response: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
Author response: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms Open
The multiplicity of neural circuits that accommodate the sheer infinite number of computations conducted by brains requires diverse synapse and neuron types. At the vertebrate presynaptic active zone functional diversity can be achieved by…
View article: Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms Open
At many vertebrate synapses, presynaptic functions are tuned by expression of different Ca v 2 channels. Most invertebrate genomes contain only one Ca v 2 gene. The Drosophila Ca v 2 homolog, cacophony (cac), induces synaptic vesicle relea…
View article: Specific presynaptic functions require distinct Drosophila Ca <sub>v</sub> 2 splice isoforms
Specific presynaptic functions require distinct Drosophila Ca <sub>v</sub> 2 splice isoforms Open
The multiplicity of neural circuits that accommodate the sheer infinite number of computations conducted by brains requires diverse synapse and neuron types. At many vertebrate synapses release probability and other aspects of presynaptic …
View article: Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval <i>Drosophila</i>
Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in Larval <i>Drosophila</i> Open
Larvae of the fruit fly Drosophila melanogaster are a powerful study case for understanding the neural circuits underlying behavior. Indeed, the numerical simplicity of the larval brain has permitted the reconstruction of its synaptic conn…
View article: Actin Y53 Phosphorylation Regulates Somatic F-actin Radial Translocation to Promote Neuronal Polarization
Actin Y53 Phosphorylation Regulates Somatic F-actin Radial Translocation to Promote Neuronal Polarization Open
How neurons accomplish the growth of an axon, and several dendrites sequentially is a cellular process not well understood. Here, we show that preferential somatic F-actin delivery to neurites inhibits neurite growth during axon formation.…
View article: Rewarding capacity of optogenetically activating a giant GABAergic central-brain interneuron in larval<i>Drosophila</i>
Rewarding capacity of optogenetically activating a giant GABAergic central-brain interneuron in larval<i>Drosophila</i> Open
Larvae of the fruit fly Drosophila melanogaster are a powerful study case for understanding the neural circuits underlying behavior. Indeed, the numerical simplicity of the larval brain has permitted the reconstruction of its synaptic conn…
View article: Centrosome-dependent microtubule modifications set the conditions for axon formation
Centrosome-dependent microtubule modifications set the conditions for axon formation Open
Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neu…
View article: Separation of presynaptic Ca <sub>v</sub> 2 and Ca <sub>v</sub> 1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca <sup>2+</sup> pump PMCA
Separation of presynaptic Ca <sub>v</sub> 2 and Ca <sub>v</sub> 1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca <sup>2+</sup> pump PMCA Open
Significance Synaptic vesicle (SV) release from presynaptic terminals requires nanometer precise control of action potential (AP)–triggered calcium influx through voltage-gated calcium channels (VGCCs). SV recycling also depends on calcium…
View article: A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval <i>Drosophila</i>
A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval <i>Drosophila</i> Open
Larval Drosophila are used as a genetically accessible study case in many areas of biological research. Here we report a fast, robust and user-friendly procedure for the whole-body multi-fluorescence imaging of Drosophila larvae; the proto…
View article: A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval<i>Drosophila</i>
A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval<i>Drosophila</i> Open
Larval Drosophila are used as a genetically accessible study case in many areas of biological research. Here we report a fast, robust and user-friendly procedure for the whole-body multifluorescence imaging of Drosophila larvae; the protoc…
View article: A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval <i>Drosophila</i>
A quick and versatile protocol for the 3D visualization of transgene expression across the whole body of larval <i>Drosophila</i> Open
Larval Drosophila are used as a genetically accessible study case in many areas of biological research. Here we report a fast, robust and user-friendly procedure for the whole-body multi-fluorescence imaging of Drosophila larvae; the proto…
View article: Centrosome-dependent microtubule organization sets the conditions for axon formation
Centrosome-dependent microtubule organization sets the conditions for axon formation Open
Microtubule remodeling is critical during axon development when the more stable microtubules populate the axon. It is not completely understood, however, how this local cytoskeleton remodeling is coordinated. The centrosome, the main micro…
View article: Struktur und Dynamik der neuromuskulären Synapse von Drosophila melanogaster : Untersuchungen am Dlg-Gerüstkomplex mittels hochauflösender Lichtmikroskopie und 3D/4D-Bildanalysen
Struktur und Dynamik der neuromuskulären Synapse von Drosophila melanogaster : Untersuchungen am Dlg-Gerüstkomplex mittels hochauflösender Lichtmikroskopie und 3D/4D-Bildanalysen Open
Brain functions, in particular learning and memory, are based on neuronal networks, which, once established are subject to experience-dependent adjustments. Neuronal networks in turn consist of neurons, which are connected with each other …
View article: F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes
F-actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes Open
Organelle positioning within neurites is required for proper neuronal function. In dendrites with their complex cytoskeletal organization, transport of organelles is guided by local specializations of the microtubule and actin cytoskeleton…
View article: Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila
Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila Open
Copper-catalyzed azide-alkyne-cycloaddition (CuAAC), also known as 'click chemistry' serves as a technique for bio-orthogonal, that is, bio-compatible labeling of macromolecules including proteins or lipids. Click chemistry has been widely…
View article: Radial F-actin Organization During Early Neuronal Development
Radial F-actin Organization During Early Neuronal Development Open
The centrosome is thought to be the major neuronal microtubule-organizing center (MTOC) in early neuronal development, producing microtubules with a radial organization. In addition, albeit in vitro, recent work showed that isolated centro…
View article: Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila
Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila Open
Advanced mass spectrometry technology has pushed proteomic analyses to the forefront of biological and biomedical research. Limitations of proteomic approaches now often remain with sample preparations rather than with the sensitivity of p…