Oliver McCallion
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View article: Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance
Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance Open
We previously showed that infiltrating cytotoxic immune cells are reprogrammed to regulatory-like/exhausted cells within accepted kidney allografts through a ‘defensive tolerance’ mechanism. We observed a regulatory B cell (Breg) signature…
View article: Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer
Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transfer Open
Adoptive transfer of antigen-specific regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. However, their low frequency in peripheral blood poses challenges for both man…
View article: Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants
Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants Open
This work was funded by the 7th EU Framework Programme, grant/award no. 260687, and the National Institute for Health Research (NIHR).
View article: Gene editing of<i>CD3 epsilon</i>gene to redirect regulatory T cells for adoptive T cell transfer
Gene editing of<i>CD3 epsilon</i>gene to redirect regulatory T cells for adoptive T cell transfer Open
I. Abstract Adoptive transfer of regulatory T cells (Tregs) is a promising strategy to combat immunopathologies in transplantation and autoimmune diseases. Antigen-specific Tregs are more effective in modulating undesired immune reactions,…
View article: Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic ‘off-the-shelf’ regulatory T cell therapy
Matching or genetic engineering of HLA Class I and II facilitates successful allogeneic ‘off-the-shelf’ regulatory T cell therapy Open
The potential to harness regulatory T cells (Tregs) for the treatment of autoimmune diseases and transplant rejection has been restricted by several barriers: donor variability, manufacturing complications, and time-consuming expansion pro…
View article: Regulatory T-cell therapy approaches
Regulatory T-cell therapy approaches Open
Summary Regulatory T cells (Tregs) have enormous therapeutic potential to treat a variety of immunopathologies characterized by aberrant immune activation. Adoptive transfer of ex vivo expanded autologous Tregs continues to progress throug…
View article: Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo
Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo Open
Cell therapies have significant therapeutic potential in diverse fields including regenerative medicine, transplantation tolerance, and autoimmunity. Within these fields, regulatory T cells (Treg) have been deployed to ameliorate aberrant …
View article: Infantile virilisation caused by an androstenedione-producing adrenal adenoma
Infantile virilisation caused by an androstenedione-producing adrenal adenoma Open
A previously well fifteen-month-old female infant presented to a district general hospital in the United Kingdom with a three-month history of virilisation developing facial acne, coarse pubic hair, labia majora hypertrophy, menstruation, …
View article: The functional neuroanatomy of musical memory in Alzheimer's disease
The functional neuroanatomy of musical memory in Alzheimer's disease Open
Our findings define functional neuroanatomical substrates for the differential involvement of musical semantic and incidental episodic memory in major phenotypes of Alzheimer's disease. The complex dynamic profile of brain activation group…
View article: Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation
Deciphering the Contribution of γδ T Cells to Outcomes in Transplantation Open
γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activiti…
View article: Music models aberrant rule decoding and reward valuation in dementia
Music models aberrant rule decoding and reward valuation in dementia Open
Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patie…
View article: Intrauterine fetal death and risk of shoulder dystocia at delivery
Intrauterine fetal death and risk of shoulder dystocia at delivery Open
Introduction Vaginal delivery is recommended after intrauterine fetal death. However, little is known about the risk of shoulder dystocia in these deliveries. We studied whether intrauterine fetal death increases the risk of shoulder dysto…
View article: P2‐099: Musical rules and reward in dementia
P2‐099: Musical rules and reward in dementia Open
Music is a universal stimulus that generates powerful emotion and reward in listeners. Responses to music depend on internalised musical 'rules' that generate strong psychological expectancies even in musically untrained individuals. Music…