Oliver Ullrich
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View article: Association of Foehn winds with physiological parameters in the general population
Association of Foehn winds with physiological parameters in the general population Open
Background Foehn winds—warm, dry downslope winds common in alpine regions—may impact human health, especially in weather-sensitive individuals, though evidence is lacking. Wearable devices now enable continuous health monitoring, offering …
View article: Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity
Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity Open
Introduction The effect of micro-gravity on the lumbar and in particular thoracic regions is poorly understood. The aim of this study was to evaluate spinal curvature across the lumbar and thoracic region, and extensor muscle activity duri…
View article: Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology
Digitalized organoids: integrated pipeline for high-speed 3D analysis of organoid structures using multilevel segmentation and cellular topology Open
Organoids replicate tissue architecture and function and offer a unique opportunity to explore the impact of external perturbations in vitro. However, conducting large-scale screening procedures to investigate the effects of various stress…
View article: Femoral nerve palsy following Girdlestone resection arthroplasty: An observational cadaveric study
Femoral nerve palsy following Girdlestone resection arthroplasty: An observational cadaveric study Open
BACKGROUND When patients with a failed hip arthroplasty are unsuitable for reimplantation, Girdlestone resection arthroplasty (GRA) is a viable treatment option. We report on a patient who was treated with a GRA due to a periprosthetic inf…
View article: Increased H3K9me3 and F-Actin Reorganization in the Rapid Adaptive Response to Hypergravity in Human T Lymphocytes
Increased H3K9me3 and F-Actin Reorganization in the Rapid Adaptive Response to Hypergravity in Human T Lymphocytes Open
Our study explored the impact of hypergravity on human T cells, which experience additional acceleration forces beyond Earth’s gravity due to various factors, such as pulsatile blood flow, and technology, such as high-performance aircraft …
View article: Digitalized organoids: integrated pipeline for 3D high-speed analysis of organoid structures using multilevel segmentation and cellular topology
Digitalized organoids: integrated pipeline for 3D high-speed analysis of organoid structures using multilevel segmentation and cellular topology Open
Analysing the tissue morphogenesis and function is crucial for unravelling the underlying mechanisms of tissue development and disease. Organoids, 3D in vitro models that mimic the architecture and function of human tissues, offer a unique…
View article: Swiss Parabolic Flights: Development of a Non-Governmental Parabolic Flight Program in Switzerland Based on the Airbus A310 ZERO-G
Swiss Parabolic Flights: Development of a Non-Governmental Parabolic Flight Program in Switzerland Based on the Airbus A310 ZERO-G Open
Parabolic flights are one of the most important pillars for research, development, and applications in space. Accordingly, we developed the world’s first non-governmental parabolic flight program using Novespace’s Airbus A310 ZERO-G. Throu…
View article: Gravity’s Influence on Human Motivation
Gravity’s Influence on Human Motivation Open
Earth’s mass generates a definitive Earth-vertical reference, shaping life’s evolution. Notably, these gravity models influence self-perception and the first-person viewpoint in the CNS, tied to bodily self-awareness and spatial orientatio…
View article: Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Expression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation Open
View article: Editorial: Space resources and planetary sustainability—challenges and opportunities
Editorial: Space resources and planetary sustainability—challenges and opportunities Open
EDITORIAL article Front. Astron. Space Sci., 06 June 2023Sec. Planetary Science Volume 10 - 2023 | https://doi.org/10.3389/fspas.2023.1200726
View article: Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols
Transcriptional Response in Human Jurkat T Lymphocytes to a near Physiological Hypergravity Environment and to One Common in Routine Cell Culture Protocols Open
Cellular effects of hypergravity have been described in many studies. We investigated the transcriptional dynamics in Jurkat T cells between 20 s and 60 min of 9 g hypergravity and characterized a highly dynamic biphasic time course of gen…
View article: Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages
Rapid Downregulation of H3K4me3 Binding to Immunoregulatory Genes in Altered Gravity in Primary Human M1 Macrophages Open
The sensitivity of human immune system cells to gravity changes has been investigated in numerous studies. Human macrophages mediate innate and thus rapid immune defense on the one hand and activate T- and B-cell-based adaptive immune resp…
View article: Sixty Years of Manned Spaceflight—Incidents and Accidents Involving Astronauts between Launch and Landing
Sixty Years of Manned Spaceflight—Incidents and Accidents Involving Astronauts between Launch and Landing Open
Introduction: Since Gagarin became the first human to travel into space and complete one orbit around the Earth, on 12 April 1961, the number of manned spaceflights has increased significantly. Spaceflight is still complex and has potentia…
View article: Gravitational Cell Biology
Gravitational Cell Biology Open
The evolution of life on Earth has been subject to a range of influences, whereas gravity was the only constant and universal force during all times of Earth's history. Since the last decades, a lot of evidence has been obtained suggesting…
View article: Post-Transcriptional Dynamics is Involved in Rapid Adaptation to Hypergravity in Jurkat T Cells
Post-Transcriptional Dynamics is Involved in Rapid Adaptation to Hypergravity in Jurkat T Cells Open
The transcriptome of human immune cells rapidly reacts to altered gravity in a highly dynamic way. We could show in previous experiments that transcriptional patterns show profound adaption after seconds to minutes of altered gravity. To g…
View article: Effects of Spaceflight on the Immune System
Effects of Spaceflight on the Immune System Open
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated microgravity. Immune system dysf…
View article: CT-based and morphological comparison of glenoid inclination and version angles and mineralisation distribution in human body donors
CT-based and morphological comparison of glenoid inclination and version angles and mineralisation distribution in human body donors Open
View article: Gravitational Force—Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells
Gravitational Force—Induced 3D Chromosomal Conformational Changes Are Associated with Rapid Transcriptional Response in Human T Cells Open
The mechanisms underlying gravity perception in mammalian cells are unknown. We have recently discovered that the transcriptome of cells in the immune system, which is the most affected system during a spaceflight, responds rapidly and bro…
View article: Rapid Transient Transcriptional Adaptation to Hypergravity in Jurkat T Cells Revealed by Comparative Analysis of Microarray and RNA-Seq Data
Rapid Transient Transcriptional Adaptation to Hypergravity in Jurkat T Cells Revealed by Comparative Analysis of Microarray and RNA-Seq Data Open
Cellular responses to micro- and hypergravity are rapid and complex and appear within the first few seconds of exposure. Transcriptomic analyses are a valuable tool to analyze these genome-wide cellular alterations. For a better understand…
View article: Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages
Metabolic Dynamics in Short- and Long-Term Microgravity in Human Primary Macrophages Open
Microgravity acts on cellular systems on several levels. Cells of the immune system especially react rapidly to changes in gravity. In this study, we performed a correlative metabolomics analysis on short-term and long-term microgravity ef…
View article: Microgravity and Hypergravity Induced by Parabolic Flight Differently Affect Lumbar Spinal Stiffness
Microgravity and Hypergravity Induced by Parabolic Flight Differently Affect Lumbar Spinal Stiffness Open
The objective of this study was to determine the response of the lumbar spinal motor control in different gravitational conditions. This was accomplished by measuring indicators of lumbar motor control, specifically lumbar spinal stiffness…
View article: Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation
Rapid Cellular Perception of Gravitational Forces in Human Jurkat T Cells and Transduction into Gene Expression Regulation Open
Cellular processes are influenced in many ways by changes in gravitational force. In previous studies, we were able to demonstrate, in various cellular systems and research platforms that reactions and adaptation processes occur very rapid…
View article: Cells´ Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight
Cells´ Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight Open
Gravitational stress in general and microgravity (µg) in particular are regarded as major stress factors responsible for immune system dysfunction in space. To assess the effects of alternating µg and hypergravity (hyper-g) on immune cells…
View article: Rapid Morphological and Cytoskeletal Response to Microgravity in Human Primary Macrophages
Rapid Morphological and Cytoskeletal Response to Microgravity in Human Primary Macrophages Open
The FLUMIAS (Fluorescence-Microscopic Analyses System for Life-Cell-Imaging in Space) confocal laser spinning disk fluorescence microscope represents a new imaging capability for live cell imaging experiments on suborbital ballistic rocket…
View article: Real-Time 3D High-Resolution Microscopy of Human Cells on the International Space Station
Real-Time 3D High-Resolution Microscopy of Human Cells on the International Space Station Open
Here we report the successful first operation of FLUMIAS-DEA, a miniaturized high-resolution 3D fluorescence microscope on the International Space Station (ISS) by imaging two scientific samples in a temperature-constant system, one sample…
View article: Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity
Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity Open
Immune system deterioration in space represents a major risk, which has to be mitigated for exploration-class missions into the solar system. Altered gravitational forces have been shown to regulate adaptation processes in cells of the imm…
View article: Effects of Spaceflight on the Immune System
Effects of Spaceflight on the Immune System Open
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated microgravity. Immune system dysf…
View article: Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity
Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity Open
Whereby several types of cultured cells are sensitive to gravity, the immune system belongs to the most affected systems during spaceflight. Since reactive oxygen species/reactive nitrogen species (ROS/RNS) are serving as signals of cellul…
View article: Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
Rapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells Open
View article: GRAIN V2.0 (Influence of altered gravity on immune responses demonstrated with neutrophil migration performance) Migration and activation of immune cells in altered gravity
GRAIN V2.0 (Influence of altered gravity on immune responses demonstrated with neutrophil migration performance) Migration and activation of immune cells in altered gravity Open
Event Abstract Back to Event GRAIN V2.0 (Influence of altered gravity on immune responses demonstrated with neutrophil migration performance) Migration and activation of immune cells in altered gravity Dominique Moser1, Shujin Sun2, Ning L…