Oliver J. Watson
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View article: Slowing artemisinin resistance in Africa
Slowing artemisinin resistance in Africa Open
Diversifying antimalarial drug use across Africa offers the most immediate strategy to slow antimalarial resistance and limit potential increases in treatment failure rates.
View article: Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions Open
Since their first detection in 2010, Plasmodium falciparum malaria parasites lacking the P. falciparum histidine-rich protein 2 gene (pfhrp2) have been observed in 40 of 47 surveyed countries, as documented by the World Health Organization…
View article: Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions Open
View article: Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic Open
View article: Toward Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The “What” and “Why”
Toward Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The “What” and “Why” Open
The coronavirus disease 2019 pandemic showcased the power of genomic surveillance in tracking infectious diseases, driving rapid public health responses, and global collaboration. This same infrastructure is being leveraged for malaria mol…
View article: The global return-on-investment of COVID-19 vaccines in the first year of the vaccination programme
The global return-on-investment of COVID-19 vaccines in the first year of the vaccination programme Open
COVID-19 vaccines played a critical role in reducing global health burden during the COVID-19 pandemic, but their rapid development required extraordinary effort. This study aims to evaluate their global return-on-investment (ROI) during t…
View article: Towards Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The “What” and the “Why”
Towards Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance with Targeted Sequencing: The “What” and the “Why” Open
The COVID-19 pandemic showcased the power of genomic surveillance in tracking infectious diseases, driving rapid public health responses, and global collaboration. This same infrastructure is being leveraged for malaria molecular surveilla…
View article: The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC Open
View article: Implementation of a national AI technology program on cardiovascular outcomes and the health system
Implementation of a national AI technology program on cardiovascular outcomes and the health system Open
Coronary artery disease (CAD) is a major cause of ill health and death worldwide. Coronary computed tomographic angiography (CCTA) is the first-line investigation to detect CAD in symptomatic patients. This diagnostic approach risks greate…
View article: Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study
Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study Open
View article: Towards Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance (MMS) with Targeted Sequencing: The “What” and the “Why”
Towards Setting Minimum and Optimal Data to Report for Malaria Molecular Surveillance (MMS) with Targeted Sequencing: The “What” and the “Why” Open
The COVID-19 pandemic showcased the power of genomic surveillance in tracking infectious diseases, driving rapid public health responses and global collaboration. This same infrastructure is being leveraged for malaria molecular surveillan…
View article: The impact of physical activity and intensity on clot mechanical microstructure and contraction in middle-aged/older habitual runners
The impact of physical activity and intensity on clot mechanical microstructure and contraction in middle-aged/older habitual runners Open
View article: Artificial intelligence for modelling infectious disease epidemics
Artificial intelligence for modelling infectious disease epidemics Open
View article: The Global Return-On-Investment of COVID-19 Vaccines in the First Year of the Vaccination Programme
The Global Return-On-Investment of COVID-19 Vaccines in the First Year of the Vaccination Programme Open
View article: Bridging the Gap: Enhancing the Evaluation & Interpretation of Epidemic Forecasts for Researchers & Policymakers in Resource-Constrained Settings
Bridging the Gap: Enhancing the Evaluation & Interpretation of Epidemic Forecasts for Researchers & Policymakers in Resource-Constrained Settings Open
View article: High frequency of artemisinin partial resistance mutations in the Great Lakes region revealed through rapid pooled deep sequencing
High frequency of artemisinin partial resistance mutations in the Great Lakes region revealed through rapid pooled deep sequencing Open
BACKGROUND: In Africa, the first Plasmodium falciparum artemisinin partial resistance mutation, was Kelch13 (K13) 561H - detected and validated at appreciable frequency in Rwanda in 2014. Surveillance to better define the extent of the eme…
View article: Impact of the 100 days mission for vaccines on COVID-19: a mathematical modelling study
Impact of the 100 days mission for vaccines on COVID-19: a mathematical modelling study Open
View article: High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing
High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing Open
Background In Africa, the first Plasmodium falciparum artemisinin partial resistance mutation was Kelch13 (K13) 561H, detected and validated at appreciable frequency in Rwanda in 2014. Surveillance to better define the extent of the emerge…
View article: Risk of selection and timelines for the continued spread of artemisinin and partner drug resistance in Africa
Risk of selection and timelines for the continued spread of artemisinin and partner drug resistance in Africa Open
long The introduction of artemisinin combination therapies (ACTs) has significantly reduced the burden of Plasmodium falciparum malaria, yet the emergence of artemisinin partial resistance (ART-R) as well as partner drug resistance threate…
View article: Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic Open
COVID-19 has underscored the need for more timely access to vaccines during future pandemics. This has motivated development of broad-spectrum vaccines providing protection against viral families, which could be stockpiled ahead of an outb…
View article: Author Correction: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context
Author Correction: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context Open
View article: Selection of artemisinin partial resistance Kelch13 mutations in Uganda in 2016-22 was at a rate comparable to that seen previously in South-East Asia
Selection of artemisinin partial resistance Kelch13 mutations in Uganda in 2016-22 was at a rate comparable to that seen previously in South-East Asia Open
Background Artemisinin partial resistance, mediated by mutations in the Plasmodium falciparum Kelch13 protein (K13), rapidly spread in South-East Asia (SEA), undermining antimalarial efficacies of artemisinin-based combination therapies (A…
View article: Harboring of Plasmodium Falciparum and Plasmodium Ovale Wallikeri Multiple Species Associated with Symptomatic Malaria in Endemic Population
Harboring of Plasmodium Falciparum and Plasmodium Ovale Wallikeri Multiple Species Associated with Symptomatic Malaria in Endemic Population Open
View article: Selection of Artemisinin Partial Resistance Kelch13 Mutations in Uganda in 2016-22 Was at a Rate Comparable to that Seen Previously in South-East Asia
Selection of Artemisinin Partial Resistance Kelch13 Mutations in Uganda in 2016-22 Was at a Rate Comparable to that Seen Previously in South-East Asia Open
View article: Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study
Long-term vaccination strategies to mitigate the impact of SARS-CoV-2 transmission: A modelling study Open
Background Vaccines have reduced severe disease and death from Coronavirus Disease 2019 (COVID-19). However, with evidence of waning efficacy coupled with continued evolution of the virus, health programmes need to evaluate the requirement…
View article: Global risk of selection and spread of<i>Plasmodium falciparum</i>histidine-rich protein 2 and 3 gene deletions
Global risk of selection and spread of<i>Plasmodium falciparum</i>histidine-rich protein 2 and 3 gene deletions Open
In the thirteen years since the first report of pfhrp2 -deleted parasites in 2010, the World Health Organization (WHO) has found that 40 of 47 countries surveyed worldwide have reported pfhrp2/3 gene deletions. Due to a high prevalence of …
View article: The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo
The epidemiology of Plasmodium vivax among adults in the Democratic Republic of the Congo Open
Reports of P. vivax infections among Duffy-negative hosts have accumulated throughout sub-Saharan Africa. Despite this growing body of evidence, no nationally representative epidemiological surveys of P. vivax in sub-Saharan Africa have be…
View article: Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach
Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach Open
View article: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context
Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context Open
Reported COVID-19 cases and associated mortality remain low in many sub-Saharan countries relative to global averages, but true impact is difficult to estimate given limitations around surveillance and mortality registration. In Lusaka, Za…
View article: Alternative epidemic indicators for COVID-19 in three settings with incomplete death registration systems
Alternative epidemic indicators for COVID-19 in three settings with incomplete death registration systems Open
Not all COVID-19 deaths are officially reported, and particularly in low-income and humanitarian settings, the magnitude of reporting gaps remains sparsely characterized. Alternative data sources, including burial site worker reports, sate…