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View article: DLK1-expressing neural progenitor cells promote tissue repair and functional recovery after cervical spinal cord injury
DLK1-expressing neural progenitor cells promote tissue repair and functional recovery after cervical spinal cord injury Open
Spinal cord injury (SCI) elicits a hostile microenvironment characterized by inflammation, gliosis, and disrupted signaling pathways that collectively impede neural repair. Neural progenitor cells (NPCs) represent a promising regenerative …
View article: Utility Engineering: Analyzing and Controlling Emergent Value Systems in AIs
Utility Engineering: Analyzing and Controlling Emergent Value Systems in AIs Open
As AIs rapidly advance and become more agentic, the risk they pose is governed not only by their capabilities but increasingly by their propensities, including goals and values. Tracking the emergence of goals and values has proven a longs…
View article: Humanity's Last Exam
Humanity's Last Exam Open
Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve over 90\% accuracy on popular benchmarks like MMLU, lim…
View article: The WMDP Benchmark: Measuring and Reducing Malicious Use With Unlearning
The WMDP Benchmark: Measuring and Reducing Malicious Use With Unlearning Open
The White House Executive Order on Artificial Intelligence highlights the risks of large language models (LLMs) empowering malicious actors in developing biological, cyber, and chemical weapons. To measure these risks of malicious use, gov…
View article: MAUD: An Expert-Annotated Legal NLP Dataset for Merger Agreement Understanding
MAUD: An Expert-Annotated Legal NLP Dataset for Merger Agreement Understanding Open
Reading comprehension of legal text can be a particularly challenging task due to the length and complexity of legal clauses and a shortage of expert-annotated datasets. To address this challenge, we introduce the Merger Agreement Understa…
View article: MAUD: An Expert-Annotated Legal NLP Dataset for Merger Agreement Understanding
MAUD: An Expert-Annotated Legal NLP Dataset for Merger Agreement Understanding Open
Steven Wang, Antoine Scardigli, Leonard Tang, Wei Chen, Dmitry Levkin, Anya Chen, Spencer Ball, Thomas Woodside, Oliver Zhang, Dan Hendrycks. Proceedings of the 2023 Conference on Empirical Methods in Natural Language Processing. 2023.
View article: Temperature as Uncertainty in Contrastive Learning
Temperature as Uncertainty in Contrastive Learning Open
Contrastive learning has demonstrated great capability to learn representations without annotations, even outperforming supervised baselines. However, it still lacks important properties useful for real-world application, one of which is u…
View article: Correction: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice
Correction: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice Open
The byline for the above article should include Anastasia Kralli as a coauthor. It should read: "Yoshitake Cho1,2∗,‡, Shizuko Tachibana1,‡, Kayla Lam1, Yoh Arita3, Shamim Khosrowjerdi1, Oliver Zhang1, Alex Liang1,2, Ruixia Li1,2, Aleksande…
View article: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice
Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice Open
View article: Explainability Metrics of Deep Convolutional Networks for Photoplethysmography Quality Assessment
Explainability Metrics of Deep Convolutional Networks for Photoplethysmography Quality Assessment Open
Photoplethysmography (PPG) is a noninvasive way to monitor various aspects of the circulatory system, and is becoming more and more widespread in biomedical processing. Recently, deep learning methods for analyzing PPG have also become pre…
View article: ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities
ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities Open
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects severa…
View article: Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity
Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Stress gates an astrocytic energy reservoir to impair synaptic plasticity
Stress gates an astrocytic energy reservoir to impair synaptic plasticity Open
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-im…
View article: <i>ZNF423</i>patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities
<i>ZNF423</i>patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities Open
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects severa…
View article: Optimal Transport Based Generative Autoencoders
Optimal Transport Based Generative Autoencoders Open
The field of deep generative modeling is dominated by generative adversarial networks (GANs). However, the training of GANs often lacks stability, fails to converge, and suffers from model collapse. It takes an assortment of tricks to solv…
View article: Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference Open
Physiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning …
View article: Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer
Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer Open
Mitochondria and oxidative metabolism are critical for maintaining cardiac muscle function. Research has shown that mitochondrial dysfunction is an important contributing factor to impaired cardiac function found in heart failure. By contr…