Olivia A. Ortelli
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View article: A review of operant ethanol self-administration using the sipper model: Methodological advances and a novel standardized analysis tool
A review of operant ethanol self-administration using the sipper model: Methodological advances and a novel standardized analysis tool Open
Despite decades of research, no new FDA-approved medications for alcohol use disorder (AUD) have emerged in over 25 years. Enhancing the translational relevance of preclinical models by more precisely capturing the behavioral and neurobiol…
View article: Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats
Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats Open
Investigating how environmental factors, such as the availability of non-ethanol alternative reinforcers, influences ethanol self-administration is critical for understanding the pathology of alcohol use disorder (AUD). Here we established…
View article: Fentanyl self‐administration is accelerated by methamphetamine co‐use and results in worsened hypodopaminergia in male, but not female rats
Fentanyl self‐administration is accelerated by methamphetamine co‐use and results in worsened hypodopaminergia in male, but not female rats Open
Combined use of fentanyl and methamphetamine (FENT + METH) has increased in recent years and has been documented in a growing number overdose deaths each year. The impact of FENT + METH on behavior and neurobiology is not well understood. …
View article: Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits
Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits Open
Synaptogyrin-3, a functionally obscure synaptic vesicle protein, interacts with vesicular monoamine and dopamine transporters, bringing together dopamine release and reuptake sites. Synaptogyrin-3 was reduced by chronic cocaine exposure in…
View article: Effects of early social isolation and adolescent single prolonged stress on anxiety‐like behaviors and voluntary ethanol consumption in female Long Evans rats
Effects of early social isolation and adolescent single prolonged stress on anxiety‐like behaviors and voluntary ethanol consumption in female Long Evans rats Open
Background Exposure to stress during childhood and adolescence is a risk factor for alcohol use disorder (AUD) and comorbid conditions, including posttraumatic stress disorder (PTSD). We previously established an adolescent social isolatio…
View article: Validation of the extinction probe trial as a measure of motivation in male and female Long Evans rats
Validation of the extinction probe trial as a measure of motivation in male and female Long Evans rats Open
Background Ethanol self‐administration is governed by appetitive and consummatory behaviors. The sipper model procedurally separates these behaviors by training rats to meet a response requirement within 20 min to obtain continuous access …
View article: A new statistical model for binge drinking pattern classification in college-student populations
A new statistical model for binge drinking pattern classification in college-student populations Open
Background Binge drinking (BD) among students is a frequent alcohol consumption pattern that produces adverse consequences. A widely discussed difficulty in the scientific community is defining and characterizing BD patterns. This study ai…
View article: Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus selectively reduces appetitive, but not consummatory, alcohol drinking‐related behaviours
Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus selectively reduces appetitive, but not consummatory, alcohol drinking‐related behaviours Open
Alcohol use disorder (AUD) and anxiety/stressor disorders frequently co‐occur and this dual diagnosis represents a major health and economic problem worldwide. The basolateral amygdala (BLA) is a key brain region that is known to contribut…