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View article: Barriers to Care for Vulvar Lichen Sclerosus
Barriers to Care for Vulvar Lichen Sclerosus Open
Vulvar lichen sclerosus (LS) causes significant morbidity, and diagnostic delays of 5–15 years are common. This study uses a previously described secret-shopper model to evaluate access to specialized vulvar care in the United States. Of 2…
View article: An Assessment of Perception and Use of Long-Lasting Insecticidal Net Among Undergraduates of the College of Health Sciences, Benue State University, Makurdi, Nigeria
An Assessment of Perception and Use of Long-Lasting Insecticidal Net Among Undergraduates of the College of Health Sciences, Benue State University, Makurdi, Nigeria Open
Background: Malaria remains a significant public health concern in Nigeria, with LLINs playing a crucial role in malaria prevention efforts. However, the perception and practice of sleeping under LLINs remain understudied. Studying LLIN us…
View article: Practices of Complementary Feeding Amongst Breastfeeding Mothers Attending Immunization Clinics in Makurdi, Benue State
Practices of Complementary Feeding Amongst Breastfeeding Mothers Attending Immunization Clinics in Makurdi, Benue State Open
Introduction: Malnutrition is a globally common problem, particularly amongst infants – this is due to the delicate balance in their system. As such, its important to institute proper feeding and nutritional measures, especially as it rela…
View article: Combination Versus Monotherapy for Carbapenem-Resistant Acinetobacter Species Serious Infections: A Prospective IPTW Adjusted Cohort Study
Combination Versus Monotherapy for Carbapenem-Resistant Acinetobacter Species Serious Infections: A Prospective IPTW Adjusted Cohort Study Open
Combination therapy for CRAB infections needs further study in a randomised controlled trial, as this observational study showed no difference in 30-day mortality between monotherapy and combination therapy.
View article: Early detection, reactivation of cytomegalovirus DNA & immediate early (IE)-mRNA expression in hematopoietic stem cell-transplant patients
Early detection, reactivation of cytomegalovirus DNA & immediate early (IE)-mRNA expression in hematopoietic stem cell-transplant patients Open
Quantification of HCMV IE-mRNA may be a valuable tool to predict progression of HCMV infection post-transplantation, with further prospective studies needed for validation.
View article: Low Dose Risperidone Prophylaxis for The Prevention of Delirium in The Intensive Care Unit: A Randomized, Placebo Controlled Trial
Low Dose Risperidone Prophylaxis for The Prevention of Delirium in The Intensive Care Unit: A Randomized, Placebo Controlled Trial Open
Background Delirium is common among patients in intensive care units. Antipsychotics have been shown to reduce the incidence of delirium in post-operative patients. We set out to compare the efficacy of risperidone to placebo in preventing…
View article: Are physicians ready for precision antibiotic prescribing? A qualitative analysis of the acceptance of artificial intelligence-enabled clinical decision support systems in India and Singapore
Are physicians ready for precision antibiotic prescribing? A qualitative analysis of the acceptance of artificial intelligence-enabled clinical decision support systems in India and Singapore Open
In conclusion, the acceptance of AI-enabled CDSSs depends on the physician's confidence with the tool's recommendations, perceived ease of use, familiarity with AI, the organisation's digital culture and support, and the presence of medico…
View article: INTRAVENOUS DOXYCYCLINE OR AZITHROMYCIN OR A COMBINATION OF THE TWO FOR TREATMENT OF SEVERE SCRUB TYPHUS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
INTRAVENOUS DOXYCYCLINE OR AZITHROMYCIN OR A COMBINATION OF THE TWO FOR TREATMENT OF SEVERE SCRUB TYPHUS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL Open
Intro: Scrub typhus, a life-threatening zoonotic bacterial infection caused by Orientia tsutsugamushi, transmitted by trombiculid mite larvae, is a public health challenge even beyond the ‘tsutsugamushi triangle’, its traditional endemic r…
View article: Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus
Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus Open
Combination therapy with intravenous doxycycline and azithromycin was a better therapeutic option for the treatment of severe scrub typhus than monotherapy with either drug alone. (Funded by the India Alliance and Wellcome Trust; INTREST C…
View article: Economic Impact, Clinical Features and Outcomes of Hospitalised Patients with SLE in India
Economic Impact, Clinical Features and Outcomes of Hospitalised Patients with SLE in India Open
Background: Systemic lupus erythematosus (SLE), a rare multisystem disorder with a female preponderance, has a high cost for the care; however, there is no evidence relevant to the Indian setting. The primary objective of our study was to …
View article: Accuracy of Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: a retrospective cohort study
Accuracy of Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: a retrospective cohort study Open
Xpert Ultra with the trace category is superior to the conventional Xpert, and mycobacterial culture in identifying TB.
View article: The role and diagnostic accuracy of serology for COVID-19
The role and diagnostic accuracy of serology for COVID-19 Open
Background The role and performance of various serological tests for the diagnosis of COVID-19 are unclear. This study aimed to evaluate the performance of seven commercially available serological assays for SARS-CoV-2 antibodies by testin…
View article: Community-acquired fungal pyelonephritis with renal infarction and gangrene of the colon: an uncommon diagnosis
Community-acquired fungal pyelonephritis with renal infarction and gangrene of the colon: an uncommon diagnosis Open
A 54-year-old male farmer with a history of long-standing uncontrolled type 2 diabetes mellitus (HbA1c 10.8) presented with a 3-week history of fever, intermittent vomiting, malaise and left flank pain for which he was treated with broad-s…
View article: Performance of molecular and serologic tests for the diagnosis of scrub typhus
Performance of molecular and serologic tests for the diagnosis of scrub typhus Open
Diagnosis of scrub typhus, caused by the bacterium Orientia tsutsugamushi , is challenging because of the overlap of its non-specific symptoms with other infections coupled with the lack of sufficient data on the performance of diagnostic …
View article: Critical Care for COVID-19 Affected Patients: Updated Position Statement of the Indian Society of Critical Care Medicine
Critical Care for COVID-19 Affected Patients: Updated Position Statement of the Indian Society of Critical Care Medicine Open
The management of coronavirus disease-2019 (COVID-19) is witnessing a change as we learn more about the pathophysiology and the severity of the disease. Several randomized controlled trials (RCTs) and meta-analysis have been published over…
View article: Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine
Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine Open
Mehta Y, Chaudhry D, Abraham OC, Chacko J, Divatia J, Jagiasi B, et al. Critical Care for COVID-19 Affected Patients: Position Statement of the Indian Society of Critical Care Medicine. Indian J Crit Care Med 2020;24(4):222-241.
View article: Direct cost of illness for dengue in hospitalized children and adults at a referral hospital in India
Direct cost of illness for dengue in hospitalized children and adults at a referral hospital in India Open
Children and adults with dengue incur high costs when hospitalized for dengue. Since most medical costs in India are out-of-pocket expenses, these illnesses can impact households.
View article: Antiretroviral Therapy under the National Program: Experience of a Single Large Centre in Southern India
Antiretroviral Therapy under the National Program: Experience of a Single Large Centre in Southern India Open
Introduction: The National Aids Control Organization (NACO) has been providing free Antiretroviral Therapy (ART) in India since 2004. Several concerns exist regarding functional outcome, possible low rates of treatment adherence, treatment…
View article: Case Report: Failure of Therapeutic Coma in Rabies Encephalitis
Case Report: Failure of Therapeutic Coma in Rabies Encephalitis Open
Rabies encephalitis is a fulminant, almost universally fatal infection involving the central nervous system. A unique treatment protocol, including anti-exicitotoxic therapy and induced coma was credited with the survival of a vaccinated t…
View article: Effect of Interleukin-28B Polymorphism on Interleukin-28 Expression and Immunological Recovery amongst HIV-1-Infected Individuals Following Antiretroviral Therapy
Effect of Interleukin-28B Polymorphism on Interleukin-28 Expression and Immunological Recovery amongst HIV-1-Infected Individuals Following Antiretroviral Therapy Open
Our preliminary findings suggest that IL-28 polymorphisms could influence both immunological recovery and therapeutic response in HIV infection. Hence, functional studies are warranted to understand the mechanistic basis of IL-28-mediated …
View article: Pre-admission antibiotics for suspected cases of meningococcal disease
Pre-admission antibiotics for suspected cases of meningococcal disease Open
We found no reliable evidence to support the use pre-admission antibiotics for suspected cases of non-severe meningococcal disease. Moderate-quality evidence from one RCT indicated that single intramuscular injections of ceftriaxone and lo…
View article: Visual Disturbance in Patients with Cryptococcal Meningitis: The Road Ahead
Visual Disturbance in Patients with Cryptococcal Meningitis: The Road Ahead Open
Visual disturbances including visual loss have been reported in up to 40% of patients with cryptococcal meningitis (CCM).[1],[2] However, there are no clear guidelines regarding the diagnosis, follow-up, and management of visual complicati…
View article: Appropriate therapy for carbapenem-resistant Enterobacteriaceae (CRE)
Appropriate therapy for carbapenem-resistant Enterobacteriaceae (CRE) Open
CRE (KPC, NDM-1 and OXA-48 type carbapenemase producers) infections, increasingly encountered across the globe, are associated with substantial (up to 40%) mortality. Treatment options are limited due to in-vitro resistance to virtually al…
View article: Acute pancreatitis due to malaria: A case report of five patients and review of literature
Acute pancreatitis due to malaria: A case report of five patients and review of literature Open
Malaria is endemic in large parts of India and can cause multiorgan failure and death. Acute pancreatitis as a complication is rare and is potentially fatal. This case series describes five adult patients between 2005 and 2010 who presente…