Jiawei Dai
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View article: Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapy
Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapy Open
Immunotherapy has rapidly emerged as a transformative advancement in cancer treatment, becoming essential for managing diverse malignancies. Despite the remarkable clinical efficacy of immunotherapies, including immune checkpoint inhibitor…
View article: Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrometry, bioinformatics, and molecular docking
Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrometry, bioinformatics, and molecular docking Open
Ethnopharmacological relevance The Shi Pi Zeng Ye Formula (SPZY), a traditional Chinese herbal compound, is empirically used for qi and yin replenishment and has been prescribed for managing functional constipation (FC) comorbid with depre…
View article: Genomic alterations in normal breast tissues preceding breast cancer diagnosis
Genomic alterations in normal breast tissues preceding breast cancer diagnosis Open
Background Normal breast tissues adjacent to cancer often harbor many of the same genomic alterations as the cancer itself. However, it remains unclear whether histologically normal breast tissues carry genomic changes related to cancer de…
View article: Immune-related adverse events are associated with better event-free survival in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage triple-negative breast cancer
Immune-related adverse events are associated with better event-free survival in a phase I/II clinical trial of durvalumab concomitant with neoadjuvant chemotherapy in early-stage triple-negative breast cancer Open
The development of irAE was associated with numerically improved pCR rates, lower RCB, and significantly higher EFS in patients treated with neoadjuvant immune checkpoint therapy plus chemotherapy.
View article: Data from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers
Data from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers Open
Purpose:The MammaPrint (MP) prognostic assay categorizes breast cancers into high- and low-risk subgroups, and the high-risk group can be further subdivided into high-1 (MP-H1), and very high-risk high-2 (MP-H2). The aim of this analysis w…
View article: Supplementary Figure 1 from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers
Supplementary Figure 1 from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers Open
Supplementary Figure 1
View article: Supplementary Tables 1 from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers
Supplementary Tables 1 from Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers Open
Supplementary Tables
View article: Mechanism of therapeutic action of Folium Artemisiae Argyi on Neuropathic pain based on network pharmacology and molecular docking technology
Mechanism of therapeutic action of Folium Artemisiae Argyi on Neuropathic pain based on network pharmacology and molecular docking technology Open
Objective To elucidate the mechanism of therapeutic action of Folium Artemisiae Argyi (FAA) on Neuropathic Pain (NP) based on network pharmacology, molecular docking and experimental verification. Methods The components of the FAA were scr…
View article: Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers
Hormone Receptor–Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers Open
Purpose: The MammaPrint (MP) prognostic assay categorizes breast cancers into high- and low-risk subgroups, and the high-risk group can be further subdivided into high-1 (MP-H1), and very high-risk high-2 (MP-H2). The aim of this analysis …
View article: Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair
Antioxidant Properties of Platycladus orientalis Flavonoids for Treating UV-Induced Damage in Androgenetic Alopecia Hair Open
Background: Androgenetic alopecia (AGA) causes thinning hair, but poor hair quality in balding areas and damage from UV radiation have been overlooked. Plant extracts like Platycladus orientalis flavonoids (POFs) may improve hair quality i…
View article: β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress
β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress Open
β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer’s disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of …
View article: Removal of hexavalent chromium from aqueous by Chitosan-stabilized FeS
Removal of hexavalent chromium from aqueous by Chitosan-stabilized FeS Open
In this study, FeS and chitosan (CTS) were compounded to form a new Cr (Ⅵ) treatment material FeS/CTS. FeS/CTS was characterized by SEM, FTIR, XRD, XPS, BET, etc, and the removal performance and mechanism of FeS/CTS for Cr (Ⅵ) were also di…
View article: CCDC 2254050: Experimental Crystal Structure Determination
CCDC 2254050: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2254047: Experimental Crystal Structure Determination
CCDC 2254047: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2254049: Experimental Crystal Structure Determination
CCDC 2254049: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2254046: Experimental Crystal Structure Determination
CCDC 2254046: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The Factor beyond Schmidt's Criteria Impacting the Photo‐Induced [2+2] Cycloaddition Reactivity and Photoactuation of Molecular Crystals Based on Cyclic Chalcone Analogues
The Factor beyond Schmidt's Criteria Impacting the Photo‐Induced [2+2] Cycloaddition Reactivity and Photoactuation of Molecular Crystals Based on Cyclic Chalcone Analogues Open
Generally, the potential reactive “olefin pairs” in the molecular crystals satisfying Schmidt's criteria could undergo topological [2+2] cycloaddition. In this study, another factor that affects the photodimerization reactivity of chalcone…
View article: Synergy effect between tetracycline and Cr(VI) on combined pollution systems driving biochar-templated Fe3O4@SiO2/TiO2/g-C3N4 composites for enhanced removal of pollutants
Synergy effect between tetracycline and Cr(VI) on combined pollution systems driving biochar-templated Fe3O4@SiO2/TiO2/g-C3N4 composites for enhanced removal of pollutants Open
Biochar-coupled Fe 3 O 4 @SiO 2 /TiO 2 /g-C 3 N 4 composites were successfully constructed through simple sol–gel and calcination methods. The composites efficiently removed high-concentration toxic tetracycline (TC) by means of ·OH and · …
View article: Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from a Data-Driven Perspective
Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from a Data-Driven Perspective Open
Comprehensive characterization of spatial and temporal gene expression patterns in humans is critical for uncovering the regulatory codes of the human genome and understanding the molecular mechanisms of human diseases. Ubiquitously expres…
View article: Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment
Analysis of prognostic and therapeutic values of drug resistance-related genes in the lung cancer microenvironment Open
Novel screening for immunotherapy targets and prognostic biomarkers in lung cancer may draw inspiration from our results.
View article: [Retracted] Leukemia Inhibitory Factor Facilitates Self‐Renewal and Differentiation and Attenuates Oxidative Stress of BMSCs by Activating PI3K/AKT Signaling
[Retracted] Leukemia Inhibitory Factor Facilitates Self‐Renewal and Differentiation and Attenuates Oxidative Stress of BMSCs by Activating PI3K/AKT Signaling Open
Objective . Transplantation of bone marrow‐derived mesenchymal stem cells (BMSCs) remains a hopeful therapeutic approach for bone defect reconstruction. Herein, we investigated the effects and mechanisms of leukemia inhibitory factor (LIF)…
View article: DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer
DNA Damage Response and Repair Gene Alterations Increase Tumor Mutational Burden and Promote Poor Prognosis of Advanced Lung Cancer Open
DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating lymphocytes, genomic instability, and tumor mutational burden (TMB). Whether DDR-related alterations relate to therapeutic response and prognosis in lung can…
View article: Lymphocyte activation gene-3 is associated with programmed death-ligand 1 and programmed cell death protein 1 in small cell lung cancer
Lymphocyte activation gene-3 is associated with programmed death-ligand 1 and programmed cell death protein 1 in small cell lung cancer Open
This study demonstrated that LAG3 is an important immune checkpoint that is closely associated with PD-1/PD-L1. LAG3 may be a promising novel immunotherapy target for SCLC.