A.C. Rossetti
YOU?
Author Swipe
View article: Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids
Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids Open
LIS1-lissencephaly is a neurodevelopmental disorder marked by reduced cortical folding and severe neurological impairment. Although all cases result from heterozygous mutations in the LIS1 gene, patients present a broad spectrum of severit…
View article: A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder
A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder Open
Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these omics and the contribution of individual cell type…
View article: A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder
A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder Open
Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these –omics and the contribution of individual cell typ…
View article: Disclosing the Risk Associated with Isolated REM Behavior Disorder: The Sleep Experts’ Perspective
Disclosing the Risk Associated with Isolated REM Behavior Disorder: The Sleep Experts’ Perspective Open
Background Isolated rapid‐eye‐movement sleep behavior disorder (iRBD) is associated with a high risk for phenoconversion to a neurodegenerative disorder, but the optimal approach for disclosure of this risk to patients is still debated. Ob…
View article: Resilience and its correlates in patients with narcolepsy type 1
Resilience and its correlates in patients with narcolepsy type 1 Open
View article: Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly
Capturing the biology of disease severity in an organoid model of LIS1-lissencephaly Open
Lissencephaly is a malformation of cortical development (MCD) characterized by reduced to absent gyri and a disorganized cortex, leading to severe neurological consequences in affected individuals, including epilepsy, intellectual disabili…
View article: Involvement of the IL-6 Signaling Pathway in the Anti-Anhedonic Effect of the Antidepressant Agomelatine in the Chronic Mild Stress Model of Depression
Involvement of the IL-6 Signaling Pathway in the Anti-Anhedonic Effect of the Antidepressant Agomelatine in the Chronic Mild Stress Model of Depression Open
Neuroinflammation has emerged as an important factor in the molecular underpinnings of major depressive disorder (MDD) pathophysiology and in the mechanism of action of antidepressants. Among the inflammatory mediators dysregulated in depr…
View article: Multidisciplinary care of patients with narcolepsy during coronavirus disease 2019 pandemic in Italy via televisit: the TElemedicine for NARcolepsy feasibility study
Multidisciplinary care of patients with narcolepsy during coronavirus disease 2019 pandemic in Italy via televisit: the TElemedicine for NARcolepsy feasibility study Open
Study Objectives Narcolepsy is a rare chronic central disorder of hypersomnolence with frequent endocrine-metabolic comorbidities. To address the complex care needs of patients during the COVID-19 emergency, we carried out a feasibility st…
View article: Human cerebral organoids reveal progenitor pathology in EML1‐linked cortical malformation
Human cerebral organoids reveal progenitor pathology in EML1‐linked cortical malformation Open
View article: Brain Derived Neurotrophic Factor Deficiency is Associated with Cognitive Impairment and Elevated Phospholipase A2 Activity in Plasma of Mice
Brain Derived Neurotrophic Factor Deficiency is Associated with Cognitive Impairment and Elevated Phospholipase A2 Activity in Plasma of Mice Open
View article: Terahertz scattering microscopy for dermatology diagnostics
Terahertz scattering microscopy for dermatology diagnostics Open
We explore the possibility of detecting anomalous structures buried under the skin surface by studying the deviations from the ideal Airy pattern of the point-spread function (PSF) of a terahertz microscope that includes the skin as one of…
View article: A comparison of machine learning classifiers for smartphone-based gait analysis
A comparison of machine learning classifiers for smartphone-based gait analysis Open
This paper proposes a reliable monitoring scheme that can assist medical specialists in watching over the patient’s condition. Although several technologies are traditionally used to acquire motion data of patients, the high costs as well …
View article: Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Open
View article: Electron Population Dynamics in Optically Pumped Asymmetric Coupled Ge/SiGe Quantum Wells: Experiment and Models
Electron Population Dynamics in Optically Pumped Asymmetric Coupled Ge/SiGe Quantum Wells: Experiment and Models Open
n-type doped Ge quantum wells with SiGe barriers represent a promising heterostructure system for the development of radiation emitters in the terahertz range such as electrically pumped quantum cascade lasers and optically pumped quantum …
View article: Differential Neuroinflammatory Response in Male and Female Mice: A Role for BDNF
Differential Neuroinflammatory Response in Male and Female Mice: A Role for BDNF Open
A growing body of evidence supports the close relationship between major depressive disorder (MDD), a severe psychiatric disease more common among women than men, and alterations of the immune/inflammatory system. However, despite the larg…
View article: Drug discovery in psychopharmacology: from 2D models to cerebral organoids
Drug discovery in psychopharmacology: from 2D models to cerebral organoids Open
Psychiatric disorders are a heterogeneous group of mental illnesses associated with a high social and economic burden on patients and society. The complex symptomatology of these disorders, coupled with our limited understanding of the str…
View article: Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone
Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone Open
Our findings suggest that the susceptibility of parvalbumin neurons to stress may represent a key mechanism contributing to functional and structural impairments in specific brain regions relevant for psychiatric disorders. Moreover, we pr…
View article: S164. GABAergic Dysfunction in the Chronic Mild Stress Model: Modulation by Lurasidone Treatment
S164. GABAergic Dysfunction in the Chronic Mild Stress Model: Modulation by Lurasidone Treatment Open
View article: T221. LURASIDONE DISPLAYS ANTIDEPRESSANT AND PRO-COGNITIVE EFFECTS IN THE CHRONIC MILD STRESS MODEL: A ROLE FOR REDOX MECHANISMS AND PARVALBUMIN EXPRESSION
T221. LURASIDONE DISPLAYS ANTIDEPRESSANT AND PRO-COGNITIVE EFFECTS IN THE CHRONIC MILD STRESS MODEL: A ROLE FOR REDOX MECHANISMS AND PARVALBUMIN EXPRESSION Open
Exposure of rodents to chronic stress is able to recapitulate a number of functional alterations that are associated with psychiatric disorders, including anhedonia and cognitive impairment. Stress-based experimental models are also useful…
View article: BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates
BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates Open
Taken together, these results indicate deficits in several parameters representative of sociability. Altered BDNF expression in the ventral striatum may contribute to the deficits in sociability in 8 months old BACHD rats. These data suppo…
View article: Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine
Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine Open
These results are useful to better characterise the association between depression and inflammation, revealing new potential targets for pharmacological intervention for depression associated to inflammation.
View article: INFLAMMATION AND VULNERABILITY FOR MAJOR DEPRESSION: IN SEARCH OF COMMON MOLECULAR PATHWAYS
INFLAMMATION AND VULNERABILITY FOR MAJOR DEPRESSION: IN SEARCH OF COMMON MOLECULAR PATHWAYS Open
The comprehension of the molecular mechanisms underpinning Major Depression (MD) is becoming a crucial issue in public health, considering that this psychiatric disorder has been estimated to become the leading cause of disability within 2…
View article: Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine
Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine Open
Objectives: Several studies reported that antidepressant drugs have immune-regulatory effects by acting on specific inflammatory mediators. However, considering the highly complex nature of the inflammatory response, we have adopted…
View article: Lipopolysaccharide does not affect sucrose intake in stress-resilient rats: potential contribution of microglia
Lipopolysaccharide does not affect sucrose intake in stress-resilient rats: potential contribution of microglia Open
View article: P.024 Stimulus-Induced Rhythmic, Periodic or Ictal Discharges (SIRPIDs): associated factors and prognostic implications
P.024 Stimulus-Induced Rhythmic, Periodic or Ictal Discharges (SIRPIDs): associated factors and prognostic implications Open
Background: SIRPIDS were first described in 2004 in patients admitted in an intensive care unit. Despite few studies attempting to better characterize SIRPIDS, their pathophysiology and clinical implication remain uncertain. Methods: Adult…
View article: Effect of the antidepressant agomelatine on the IL-6 pathway in rats exposed to chronic mild stress: role of suppressor of cytokine signaling 3 SOCS3
Effect of the antidepressant agomelatine on the IL-6 pathway in rats exposed to chronic mild stress: role of suppressor of cytokine signaling 3 SOCS3 Open
View article: Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices
Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices Open
Although activity-dependent transcription represents a crucial mechanism for long-lasting experience-dependent changes in the hippocampus, limited data exist on its contribution to pathological conditions. We aim to investigate the influen…
View article: Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention
Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention Open
View article: Effect of the antidepressant agomelatine on the inflammatory response induced by lipopolysaccharide: a genome-wide study in the rat ventral hippocampus
Effect of the antidepressant agomelatine on the inflammatory response induced by lipopolysaccharide: a genome-wide study in the rat ventral hippocampus Open
View article: Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: modulatory activity of chronic treatment with the antidepressant agomelatine
Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: modulatory activity of chronic treatment with the antidepressant agomelatine Open