Olivia Gugliemini
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View article: Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma
Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma Open
CD38 is a surface ectoenzyme expressed at high levels on myeloma plasma cells and is the target for the monoclonal antibodies (mAbs) daratumumab and isatuximab. Pre-treatment CD38 density on tumor cells is an important determinant of mAb e…
View article: Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis Open
Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor cells in patients. Here, we employ a recently-described method of transcriptiona…
View article: Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas
Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas Open
Since Zika virus (ZIKV) was detected in Brazil in 2015, it has spread explosively across the Americas and has been linked to increased incidence of microcephaly and Guillain-Barré syndrome (GBS). In one year, it has infected over 500,000 p…