Olivia Hunker
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View article: AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms
AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms Open
DNA replication initiation is a tightly regulated process that requires the coordinated assembly of replication machineries throughout the genome. During the first step of initiation, origin licensing, the MCM replicative helicase motor is…
View article: Multiple pathways for licensing human replication origins
Multiple pathways for licensing human replication origins Open
Summary The loading of replicative helicases constitutes an obligatory step in the assembly of DNA replication machineries. In eukaryotes, the MCM2-7 replicative helicase motor is deposited onto DNA by the origin recognition complex (ORC) …
View article: Abstract 1772 Multiple pathways for licensing human replication origins
Abstract 1772 Multiple pathways for licensing human replication origins Open
The loading of replicative helicases constitutes an obligatory step in the assembly of DNA replication machineries and in constructing bidirectional replication forks. In eukaryotes, the replicative helicase motor is the Mcm2-7 hexamer tha…
View article: Exploring novel <scp>HIV</scp>‐1 reverse transcriptase inhibitors with drug‐resistant mutants: A double mutant surprise
Exploring novel <span>HIV</span>‐1 reverse transcriptase inhibitors with drug‐resistant mutants: A double mutant surprise Open
HIV‐1 reverse transcriptase (RT) remains a key target for HIV drug development. As successful management of the disease requires lifelong treatment, the emergence of resistance mutations is inevitable, making development of new RT inhibito…
View article: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6 Open
The coordinated action of multiple replicative helicase loading factors is needed for the licensing of replication origins prior to DNA replication. Binding of the Origin Recognition Complex (ORC) to DNA initiates the ATP-dependent recruit…
View article: Fabrication and Characterization of Asymmetric Phosphoinositide-Containing Vesicles
Fabrication and Characterization of Asymmetric Phosphoinositide-Containing Vesicles Open
Biological membranes are vertically asymmetric and contain lipid rafts. Experimental evidence has linked phosphoinositide (PIP) mediated signaling events to lipid rafts. Interactions between lipid rafts and PIPs would provide an efficient …