Olivia Q. Antao
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View article: CD9 Identifies and Regulates a Highly Functional T Follicular Helper (Tfh) Cell Subset Necessary for Promoting Antibodies During Infection
CD9 Identifies and Regulates a Highly Functional T Follicular Helper (Tfh) Cell Subset Necessary for Promoting Antibodies During Infection Open
View article: Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus
Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus Open
Autoimmune diseases such as lupus are characterized by polyclonal B cell activation, leading to the production of autoantibodies. The mechanism leading to B cell dysregulation is unclear; however, the defect may lie in selection within ger…
View article: A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection
A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection Open
View article: A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection
A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection Open
Current antigen delivery platforms, such as alum and nanoparticles, are not readily tunable, thus may not generate optimal adaptive immune responses. We created an antigen delivery platform by loading lyophilized Microporous Annealed Parti…
View article: Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine
Improved Humoral Immunity and Protection against Influenza Virus Infection with a 3d Porous Biomaterial Vaccine Open
New vaccine platforms that activate humoral immunity and generate neutralizing antibodies are required to combat emerging pathogens, including influenza virus. A slurry of antigen‐loaded hydrogel microparticles that anneal to form a porous…
View article: Impaired expansion and selection of geminal center B cells in lupus drives autoantibody-producing cells
Impaired expansion and selection of geminal center B cells in lupus drives autoantibody-producing cells Open
Lupus is a systemic autoimmune disease characterized by the presence of autoantibodies that form immune complexes in tissues leading to the recruitment of immune cells and subsequent inflammation and organ damage. The origin of autoantibod…
View article: CD9 identifies and regulates a highly functional and unique subset of T follicular helper (Tfh) cells necessary for the promotion of antibodies during infection
CD9 identifies and regulates a highly functional and unique subset of T follicular helper (Tfh) cells necessary for the promotion of antibodies during infection Open
T follicular helper (Tfh) cells comprise a subset of CD4+ T helper (Th) cells phenotypically and functionally distinct from Th1 and Th2 cell subsets. Tfh cells are located within B cell follicles and germinal centers (GC), where they secre…
View article: Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine
Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine Open
New vaccine platforms that properly activate humoral immunity and generate neutralizing antibodies are required to combat emerging and re-emerging pathogens, including influenza virus. Biomaterial scaffolds with macroscale porosity have de…
View article: Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers Open
View article: Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion
Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion Open
View article: Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus
Type I Interferon–Activated STAT4 Regulation of Follicular Helper T Cell–Dependent Cytokine and Immunoglobulin Production in Lupus Open
Objective To assess the role of STAT4 activation in driving pathogenic follicular helper T (Tfh) cell secretion of the cytokines interleukin‐21 (IL‐21) and interferon‐γ (IFNγ) in murine and human lupus. Methods The effect of STAT4‐dependen…
View article: Development of Tbet- and CD11c-Expressing B Cells in a Viral Infection Requires T Follicular Helper Cells Outside of Germinal Centers
Development of Tbet- and CD11c-Expressing B Cells in a Viral Infection Requires T Follicular Helper Cells Outside of Germinal Centers Open
View article: Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion
Lung macrophages mediate helminth resistance through differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion Open
Macrophages are known to mediate anti-helminth responses, but it remains uncertain which subsets are involved or how macrophages actually kill helminths. Here we show rapid monocyte recruitment to the lung after infection with the nematode…
View article: Pregnancy Downregulates Plasmablast Metabolic Gene Expression Following Influenza Without Altering Long-Term Antibody Function
Pregnancy Downregulates Plasmablast Metabolic Gene Expression Following Influenza Without Altering Long-Term Antibody Function Open
While the majority of influenza-infected individuals show no or mild symptomatology, pregnant women are at higher risk of complications and infection-associated mortality. Although enhanced lung pathology and dysregulated hormones are thou…
View article: Zika virus-induced neuro-ocular pathology in immunocompetent mice correlates with anti-ganglioside autoantibodies
Zika virus-induced neuro-ocular pathology in immunocompetent mice correlates with anti-ganglioside autoantibodies Open
A severe consequence of adult Zika virus (ZIKV) infection is Guillain-Barré Syndrome (GBS), where autoreactive antibodies attack peripheral and central nervous systems (CNS) resulting in neuro-ocular pathology and fatal complications. Duri…
View article: Cutaneous vaccination ameliorates Zika virus-induced neuro-ocular pathology via reduction of anti-ganglioside antibodies
Cutaneous vaccination ameliorates Zika virus-induced neuro-ocular pathology via reduction of anti-ganglioside antibodies Open
Zika virus (ZIKV) causes moderate to severe neuro-ocular sequelae, with symptoms ranging from conjunctivitis to Guillain-Barré Syndrome (GBS). Despite the international threat ZIKV poses, no licensed vaccine exists. As ZIKV and DENV are cl…
View article: Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza
Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza Open
The widely used influenza subunit vaccine would benefit from increased protection rates in vulnerable populations. Skin immunization by microneedle (MN) patch can increase vaccine immunogenicity, as well as increase vaccination coverage du…
View article: H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation
H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation Open
Increased susceptibility to influenza virus infection during pregnancy has been attributed to immunological changes occurring before and during gestation in order to "tolerate" the developing fetus. These systemic changes are most often ch…