Olivia Uddin
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View article: Ehlers-Danlos syndromes and their manifestations in the visual system
Ehlers-Danlos syndromes and their manifestations in the visual system Open
Ehlers-Danlos syndrome (EDS) is a rare, genetically variable, heterogenous group of (currently recognized) thirteen connective tissue disorders characterized by skin hyperextensibility, tissue fragility, and generalized joint hypermobility…
View article: Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection
Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection Open
Migraines cause significant disability and contribute heavily to healthcare costs. Irritation of the meninges' outermost layer (the dura mater), and trigeminal ganglion activation contribute to migraine initiation. Maladaptive changes in c…
View article: Divergent profiles of fentanyl withdrawal and associated pain in mice and rats
Divergent profiles of fentanyl withdrawal and associated pain in mice and rats Open
Opioid abuse has devastating effects on patients, their families, and society. Withdrawal symptoms are severely unpleasant, prolonged, and frequently hinder recovery or lead to relapse. The sharp increase in abuse and overdoses arising fro…
View article: Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection
Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection Open
Migraines cause significant disability and contribute heavily to healthcare costs. Irritation of the meninges’ outermost layer (the dura mater), and trigeminal ganglion activation contribute to migraine initiation. Maladaptive changes in c…
View article: Ventral arkypallidal neurons modulate accumbal firing to promote reward consumption
Ventral arkypallidal neurons modulate accumbal firing to promote reward consumption Open
A pause in firing of nucleus accumbens shell (NAcSh) neurons is critical for reward consumption; however, the substrate driving this pause is unknown. While ventral pallidal (VP) activity encodes reward value, the specific roles of VP subp…
View article: An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain
An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain Open
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We have recently reported that chronic pain is associated with amplified activi…
View article: An amygdalo-parabrachial pathway regulates pain perception and chronic pain
An amygdalo-parabrachial pathway regulates pain perception and chronic pain Open
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pain pathway. We have recently reported that chronic pain is associated with amplified activi…
View article: Parabrachial Complex: A Hub for Pain and Aversion
Parabrachial Complex: A Hub for Pain and Aversion Open
The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain, and multiple aspects of autonomic control, including re…
View article: Chronic pain after blast-induced traumatic brain injury in awake rats
Chronic pain after blast-induced traumatic brain injury in awake rats Open
Explosive blast-induced traumatic brain injury (blast-TBI) in military personnel is a leading cause of injury and persistent neurological abnormalities, including chronic pain. We previously demonstrated that chronic pain after spinal cord…
View article: Cortical Regulation of Nociception of the Trigeminal Nucleus Caudalis
Cortical Regulation of Nociception of the Trigeminal Nucleus Caudalis Open
Pain perception is strongly influenced by descending pathways from “higher” brain centers that regulate the activity of spinal circuits. In addition to the extensively studied descending system originating from the medulla, the neocortex p…