Olivia Walch
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View article: CNSC-45. DAILY LOCOMOTOR ACTIVITY DECLINES WITH TUMOR GROWTH AND PRECEDES CLINICAL DETECTION OF PROGRESSION IN GLIOBLASTOMA
CNSC-45. DAILY LOCOMOTOR ACTIVITY DECLINES WITH TUMOR GROWTH AND PRECEDES CLINICAL DETECTION OF PROGRESSION IN GLIOBLASTOMA Open
Glioblastoma (GBM) is an aggressive brain tumor that often progresses despite resection and treatment. Early detection of GBM progression is critical to improve patient survival. Current detection approaches require costly and specialized …
View article: Circadian variation in MGMT promoter methylation and expression predicts sensitivity to Temozolomide in glioblastoma
Circadian variation in MGMT promoter methylation and expression predicts sensitivity to Temozolomide in glioblastoma Open
Purpose Recent studies show that glioblastoma (GBM) is more sensitive to Temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent TMZ efficacy, suggesting that circadian…
View article: Tracking Daily Variations in Rest-Wake to Guide Personalized Timing of Temozolomide for High-Grade Glioma Patients
Tracking Daily Variations in Rest-Wake to Guide Personalized Timing of Temozolomide for High-Grade Glioma Patients Open
High-grade gliomas, like glioblastoma multiforme (GBM), are the most common malignant brain tumors in adults and are treated with the chemotherapy drug temozolomide (TMZ). In humans, a retrospective analysis of patients’ overall survival s…
View article: 0439 Combining Wearables with Nearables: Using a Multi-Device Machine Learning Approach Improves Sleep Tracking at Home
0439 Combining Wearables with Nearables: Using a Multi-Device Machine Learning Approach Improves Sleep Tracking at Home Open
Introduction Wearables have expanded access to sleep data, but proprietary algorithms are inaccurate and legacy actigraphy algorithms are outdated. Furthermore, legacy algorithms were trained on nighttime sleep, and only identify 50.3% of …
View article: 0884 User Experience of a Mobile Application to Reduce Circadian Misalignment in Night Shift Workers
0884 User Experience of a Mobile Application to Reduce Circadian Misalignment in Night Shift Workers Open
Introduction Around 80% of night shift workers experience circadian misalignment, leading to excessive sleepiness and decline of safety and work satisfaction. To address this, our team developed a mobile application, Arcashift, which track…
View article: 0883 Use of Apple Watch to Optimize Light Therapy and Reduce Circadian Misalignment for Night Shift Workers
0883 Use of Apple Watch to Optimize Light Therapy and Reduce Circadian Misalignment for Night Shift Workers Open
Introduction Circadian misalignment can be alleviated with targeted light interventions. However, general “light at night” interventions do not account for shift workers’ variable circadian phases. Recently, our lab validated Apple Watch (…
View article: A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue
A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue Open
Lighting interventions can mitigate fatigue by promoting circadian rhythmicity. We test whether individualized, wearable-based lighting interventions delivered via a mobile app reduce cancer-related fatigue in a randomized controlled trial…
View article: 0285 Measuring Sleep with the Apple Watch: A Comparison of a Machine Learning versus Traditional Algorithms to Actiwatch
0285 Measuring Sleep with the Apple Watch: A Comparison of a Machine Learning versus Traditional Algorithms to Actiwatch Open
Introduction Consumer-based actigraphy has seen rapid adoption in the United States and presents an underutilized opportunity and resource for ecologically valid sleep-wake monitoring. Furthermore, with the discontinuation of Philips Actiw…
View article: The combination of topological data analysis and mathematical modeling improves sleep stage prediction from consumer-grade wearables
The combination of topological data analysis and mathematical modeling improves sleep stage prediction from consumer-grade wearables Open
Wearable devices have become commonplace tools for tracking behavioral and physiological parameters in real-world settings. Nonetheless, the practical utility of these data for clinical and research applications, such as sleep analysis, is…
View article: Preliminary evidence of psychological improvements and increased maternal–fetal attachment associated with a mindfulness sleep programme: secondary analysis of uncontrolled data in 11 pregnant women with insomnia disorder
Preliminary evidence of psychological improvements and increased maternal–fetal attachment associated with a mindfulness sleep programme: secondary analysis of uncontrolled data in 11 pregnant women with insomnia disorder Open
Summary Treating insomnia during pregnancy improves sleep and depressed mood. However, given well‐established links between poor sleep and a broad spectrum of adverse maternal outcomes, the benefits of insomnia care may reach beyond sleep …
View article: 0004 Using Apple Watch to predict circadian phase in night shift workers
0004 Using Apple Watch to predict circadian phase in night shift workers Open
Introduction A critical obstacle for circadian medicine is the lack of feasibility in measuring circadian phase in the clinic. Existing tools such as assessment of dim light melatonin onset (DLMO) are too resource intensive, especially in …
View article: 0269 No More Actiwatches: Can Apple Watches be a More Scalable Alternative?
0269 No More Actiwatches: Can Apple Watches be a More Scalable Alternative? Open
Introduction The Philips Respironics Actiwatch has become a gold standard for actigraphy data collection. With the announcement of their discontinuation, there has been increased momentum to identify an alternative, particularly with consu…
View article: 0317 A single-arm proof-of-concept clinical trial of a mindfulness-based intervention for prenatal insomnia
0317 A single-arm proof-of-concept clinical trial of a mindfulness-based intervention for prenatal insomnia Open
Introduction Cognitive behavioral therapy for insomnia (CBTI) improves sleep in pregnancy, but its therapeutic benefits may be diminished in pregnancy due to undertreatment of cognitive arousal (i.e., heightened cognitive activity, especia…
View article: Validation of the Entrainment Signal Regularity Index and associations with children's changes in BMI
Validation of the Entrainment Signal Regularity Index and associations with children's changes in BMI Open
A bstract Objective This study examined the validity of a novel metric of circadian health, the Entrainment Signal Regularity Index (ESRI), and its relationship to changes in BMI during the school year and summer. Methods In a longitudinal…
View article: Reducing cognitive arousal and sleep effort alleviates insomnia and depression in pregnant women with DSM-5 insomnia disorder treated with a mindfulness sleep program
Reducing cognitive arousal and sleep effort alleviates insomnia and depression in pregnant women with DSM-5 insomnia disorder treated with a mindfulness sleep program Open
Objectives Combining mindfulness with behavioral sleep strategies has been found to alleviate symptoms of insomnia and depression during pregnancy, but mechanisms for this treatment approach remain unclear. The present study examined noctu…
View article: 0001 Associations Between Circadian Factors and Travel Distance with Performance: A retrospective analysis of 2014-2018 National Basketball Association Data
0001 Associations Between Circadian Factors and Travel Distance with Performance: A retrospective analysis of 2014-2018 National Basketball Association Data Open
Introduction Frequent travel across time zones and travelling long distances interferes with healthy sleep and disrupts the circadian system, often degrading athletic performance. National Basketball Association (NBA) players face a demand…
View article: Estimating circadian phase in elementary school children: leveraging advances in physiologically informed models of circadian entrainment and wearable devices
Estimating circadian phase in elementary school children: leveraging advances in physiologically informed models of circadian entrainment and wearable devices Open
Study Objectives Examine the ability of a physiologically based mathematical model of human circadian rhythms to predict circadian phase, as measured by salivary dim light melatonin onset (DLMO), in children compared to other proxy measure…
View article: Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers Open
Mobile measures of human circadian rhythms (CR) are needed in the age of chronotherapy. Two wearable measures of CR have recently been validated: one that uses heart rate to extract circadian rhythms that originate in the sinoatrial node o…
View article: Predicting circadian phase across populations: a comparison of mathematical models and wearable devices
Predicting circadian phase across populations: a comparison of mathematical models and wearable devices Open
From smart work scheduling to optimal drug timing, there is enormous potential in translating circadian rhythms research results for precision medicine in the real world. However, the pursuit of such effort requires the ability to accurate…
View article: M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock
M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock Open
Proper circadian photoentrainment is crucial for the survival of many organisms. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) can use the photopigment melanopsin to sense light independently from rod and cone ph…
View article: Optimal adjustment of the human circadian clock in the real world
Optimal adjustment of the human circadian clock in the real world Open
Which suggestions for behavioral modifications, based on mathematical models, are most likely to be followed in the real world? We address this question in the context of human circadian rhythms. Jet lag is a consequence of the misalignmen…
View article: Predicting circadian misalignment with wearable technology: validation of wrist-worn actigraphy and photometry in night shift workers
Predicting circadian misalignment with wearable technology: validation of wrist-worn actigraphy and photometry in night shift workers Open
Study Objectives A critical barrier to successful treatment of circadian misalignment in shift workers is determining circadian phase in a clinical or field setting. Light and movement data collected passively from wrist actigraphy can gen…