Olivier Gandrillon
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View article: Mast cells act as pro-angiogenic and pro-tumorigenic players in pituitary gonadotroph tumors
Mast cells act as pro-angiogenic and pro-tumorigenic players in pituitary gonadotroph tumors Open
Background The tumor microenvironment (TME) represents a promising avenue to understand gonadotroph tumors and develop therapeutic tools. Here, we aimed to gain insight into the tumorigenesis mechanisms driven by the gonadotroph TME. Metho…
View article: Inferring and simulating a gene regulatory network for the sympathoadrenal differentiation from single-cell transcriptomics in human.
Inferring and simulating a gene regulatory network for the sympathoadrenal differentiation from single-cell transcriptomics in human. Open
Background Neuroblastoma is a malignant childhood cancer with significant inter- and intrapatient heterogeneity arising from the abnormal differentiation of neural crest cells into sympathetic neurons. The lack of actionable mutations limi…
View article: Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short range diffusive process
Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short range diffusive process Open
Neuroblastomas are heterogeneous pediatric tumors of the sympathetic nervous system for which treatments are still limited. Fundamental and applied approaches have been enabled thanks to the generation of patient-derived tumoroids (PDTs), …
View article: Identification of Nanog-Helper Genes in Early Mouse Embryo Differentiation Using Differential Entropy and Network Inference
Identification of Nanog-Helper Genes in Early Mouse Embryo Differentiation Using Differential Entropy and Network Inference Open
In the preimplantation mammalian embryo, stochastic cell-to-cell expression heterogeneity is followed by signal reinforcement to initiate the specification of Inner Cell Mass (ICM) cells into Epiblast (Epi). The expression of NANOG, the ke…
View article: Inferring and simulating a gene regulatory network for the sympathoadrenal differentiation from single-cell transcriptomics in human
Inferring and simulating a gene regulatory network for the sympathoadrenal differentiation from single-cell transcriptomics in human Open
Background Neuroblastoma is a malignant childhood cancer with significant inter- and intrapatient heterogeneity arising from the abnormal differentiation of neural crest cells into sympathetic neurons. The lack of actionable mutations limi…
View article: A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function
A temporary challenge by tumor cells can lead to a permanent partial-impairment of memory CD8 T cell function Open
Memory CD8 T cells typically exhibit improved effector functions compared to their naive counterparts. However, under certain activation conditions, such as chronic viral infections or cancer, these cells may develop functional defects. In…
View article: Differential entropy as a measure of initial heterogeneity driving differentiation in the early mouse embryo
Differential entropy as a measure of initial heterogeneity driving differentiation in the early mouse embryo Open
Background: Heterogeneity in gene expression among single cells is critical for cell differentiation. In the preimplantation mammalian embryo, stochastic cell-to-cell expression heterogeneity is followed by signal reinforcement to initiate…
View article: 8322 Mast Cells: a New Player in Gonadotroph Tumors
8322 Mast Cells: a New Player in Gonadotroph Tumors Open
Disclosure: M. Ilie: None. M. Lepetit: None. M. Chanal: None. A. Vasiljevic: None. E. Jouanneau: None. O. Gandrillon: None. F. Picard: None. G. Raverot: None. P. Bertolino: None. Context: While gonadotroph tumors lack both prognostic marke…
View article: In silico modelling of CD8 T cell immune response links genetic regulation to population dynamics
In silico modelling of CD8 T cell immune response links genetic regulation to population dynamics Open
International audience
View article: MYC shapes ER-mitochondria calcium transfer by directly targeting<i>ITPR1</i>: implications for MYC-induced safeguard mechanisms and cancer
MYC shapes ER-mitochondria calcium transfer by directly targeting<i>ITPR1</i>: implications for MYC-induced safeguard mechanisms and cancer Open
The MYC and NMYC transcription factors (TFs) play a key role in cell proliferation and are overexpressed in most cancer cells. However, in normal cells their overexpression triggers safeguard mechanisms promoting cell death and cellular se…
View article: In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection
In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection Open
CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell…
View article: Multiscale chromatin dynamics and high entropy in plant iPSC ancestors
Multiscale chromatin dynamics and high entropy in plant iPSC ancestors Open
Plant protoplasts provide starting material for of inducing pluripotent cell masses that are competent for tissue regeneration in vitro, analogous to animal induced pluripotent stem cells (iPSCs). Dedifferentiation is associated with large…
View article: Modeling relaxation experiments with a mechanistic model of gene expression
Modeling relaxation experiments with a mechanistic model of gene expression Open
Background In the present work, we aimed at modeling a relaxation experiment which consists in selecting a subfraction of a cell population and observing the speed at which the entire initial distribution for a given marker is reconstitute…
View article: Stochastic modeling of a gene regulatory network driving B cell development in germinal centers
Stochastic modeling of a gene regulatory network driving B cell development in germinal centers Open
Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexp…
View article: Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions
Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions Open
To investigate the impact of paracrine IL-2 signals on memory precursor (MP) cell differentiation, we activated CD8 T cell in vitro in the presence or absence of exogenous IL-2 (ex-IL-2). We assessed memory differentiation by transferring …
View article: <i>In silico</i>modelling of CD8 T cell immune response links genetic regulation to population dynamics
<i>In silico</i>modelling of CD8 T cell immune response links genetic regulation to population dynamics Open
The CD8 T cell immune response operates at multiple temporal and spatial scales, including all the early complex biochemical and biomechanical processes, up to long term cell population behavior. In order to model this response, we devised…
View article: Simuscale: un outil pour la simulation multi-echelles de populations cellulaires
Simuscale: un outil pour la simulation multi-echelles de populations cellulaires Open
Simuscale is a multiscale, individual-based modelling platform for performingnumerical simulations of heterogeneous populations of individual cells evolvingin time and interacting physically and biochemically. Models are described attwo le…
View article: scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data
scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data Open
Single cell transcriptomics has recently seen a surge in popularity, leading to the need for data analysis pipelines that are reproducible, modular, and interoperable across different systems and institutions. To meet this demand, we intro…
View article: Multiscale chromatin dynamics and high entropy in plant iPSC ancestors
Multiscale chromatin dynamics and high entropy in plant iPSC ancestors Open
Plant protoplasts constitute the starting material to induce pluripotent cell masses in vitro competent for tissue regeneration. Dedifferentiation is associated with large-scale chromatin reorganisation and massive transcriptome reprogramm…
View article: <i>In silico</i>single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection
<i>In silico</i>single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection Open
CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell…
View article: An image-guided microfluidic system for single-cell lineage tracking
An image-guided microfluidic system for single-cell lineage tracking Open
Cell lineage tracking is a long-standing and unresolved problem in biology. Microfluidic technologies have the potential to address this problem, by virtue of their ability to manipulate and process single-cells in a rapid, controllable an…
View article: S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES
S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES Open
Background: Myelodysplastic syndromes (MDS) represent a heterogeneous group of bone marrow disorders characterized by clonal evolution starting from the HSPCs compartment that contains the cell of origin for MDS. Stratification of patients…
View article: Single-cell transcriptional uncertainty landscape of cell differentiation
Single-cell transcriptional uncertainty landscape of cell differentiation Open
Background: Single-cell studies have demonstrated the presence of significant cell-to-cell heterogeneity in gene expression. Whether such heterogeneity is only a bystander or has a functional role in the cell differentiation process is st…
View article: Kernel-Based Testing for Single-Cell Differential Analysis
Kernel-Based Testing for Single-Cell Differential Analysis Open
Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for non-linear cell-wise distribution comparison, analyzing gene expression and epigen…
View article: TopoDoE: A Design of Experiment strategy for selection and refinement in ensembles of executable Gene Regulatory Networks
TopoDoE: A Design of Experiment strategy for selection and refinement in ensembles of executable Gene Regulatory Networks Open
Background Inference of Gene Regulatory Networks (GRNs) is a difficult and long-standing question in Systems Biology. Numerous approaches have been proposed with the latest methods exploring the richness of single-cell data. One of the cur…