Olivier Meilhac
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View article: Impact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis
Impact of the type of bacteria on high-density lipoprotein cholesterol level during sepsis Open
High-density lipoproteins (HDL) are nanoparticles that enable the reverse transport of cholesterol and have multiple endothelioprotective properties that may play a role in sepsis, where HDL-cholesterol (HDL-C) concentrations typically plu…
View article: Effects of Porphyromonas gingivalis Bacteria on Inflammation, Oxidative Stress and Lipid Metabolism in Models of Obese db/db Mice and 3T3-L1 Adipose Cells
Effects of Porphyromonas gingivalis Bacteria on Inflammation, Oxidative Stress and Lipid Metabolism in Models of Obese db/db Mice and 3T3-L1 Adipose Cells Open
During periodontitis, Porphyromonas gingivalis and its lipopolysaccharides (LPS) may translocate into the bloodstream and alter adipocyte function, aggravating obesity-related disorders. This study aimed to evaluate the inflammatory and me…
View article: Toxicity and therapeutic effects of aqueous extracts from reunionese medicinal plants: Insights from zebrafish models
Toxicity and therapeutic effects of aqueous extracts from reunionese medicinal plants: Insights from zebrafish models Open
This work presents the first comprehensive analysis of the composition and in vivo activity of these 11 Reunionese medicinal plants. It demonstrates the therapeutic value of such extracts in managing oxidative stress, enhancing regeneratio…
View article: Aerosolized ApoA1 Nanoparticles Synthesized by Microfluidics Cross the Lung Barrier and Modulate Inflammation
Aerosolized ApoA1 Nanoparticles Synthesized by Microfluidics Cross the Lung Barrier and Modulate Inflammation Open
High-density lipoproteins exert vasculoprotective effects, mainly through apolipoprotein A1, which has led to the development of treatments based on apolipoprotein A1 nanoparticles (A1NPs) administered intravenously, mainly for the treatme…
View article: NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development
NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development Open
Our data demonstrate that NLRP3-inflammasome, carried by EVs, is actively involved in vascular inflammation and atherosclerosis development in MetS. We highlight NLRP3 carried by EVs as potential biomarker and target for potential therapeu…
View article: NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development
NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development Open
Background Inappropriate activation of the Nod-like receptor protein 3 (NLRP3)-inflammasome contributes to atherosclerosis progression and plaque instability in patients with cardiovascular events. However, its role in the atherosclerosis …
View article: PCSK9 deficiency promotes the development of peripheral neuropathy
PCSK9 deficiency promotes the development of peripheral neuropathy Open
Proprotein convertase subtilisin/kexin type 9 (PCSK9) induces the hepatic degradation of the low-density lipoprotein receptor (LDLR), thereby increasing the concentration of LDL-cholesterol in the blood. Beyond its effects on LDL, recent s…
View article: High-density lipoproteins and COVID-19: preparing the next pandemic
High-density lipoproteins and COVID-19: preparing the next pandemic Open
View article: Production, characterization and biodistribution of therapeutic high-density lipoprotein-like nanoparticles reconstituted with or without histidine-tagged recombinant ApoA1
Production, characterization and biodistribution of therapeutic high-density lipoprotein-like nanoparticles reconstituted with or without histidine-tagged recombinant ApoA1 Open
High-density lipoproteins (HDLs) are known for their cardiovascular protection due to apolipoprotein A-1 (ApoA1), their primary protein. ApoA1 promotes cholesterol reverse transport and exhibits antioxidant and anti-inflammatory properties…
View article: HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients
HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients Open
In conclusion, we have shown an alteration in plasma apolipoproteins and HDL composition between surviving COVID-19 patients and non-survivors. Some markers, such as Apo H, are more predictive than baseline lipid concentrations such as HDL…
View article: Effect of metabolic disorders on reactive gliosis and glial scarring at the early subacute phase of stroke in a mouse model of diabetes and obesity
Effect of metabolic disorders on reactive gliosis and glial scarring at the early subacute phase of stroke in a mouse model of diabetes and obesity Open
It is well recognized that type II Diabetes (T2D) and overweight/obesity are established risk factors for stroke, worsening also their consequences. However, the underlying mechanisms by which these disorders aggravate outcomes are not yet…
View article: Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis
Gene expression patterns of the LDL receptor and its inhibitor Pcsk9 in the adult zebrafish brain suggest a possible role in neurogenesis Open
The low‐density lipoprotein receptor (LDLr) is the first member of a closely related transmembrane protein family. It is known for its involvement in various physiological processes, mainly in the regulation of lipid metabolism, especially…
View article: HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients
HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients Open
Background: SARS-CoV-2 infection affects both lipid metabolism and lung function. The severity of the disease has been associated with reduced levels of both high-density lipoprotein (HDL) and low-density lipoprotein cholesterol. Despite t…
View article: Metabolic Dependency Shapes Bivalent Antiviral Response in Host Cells in Response to Poly:IC: The Role of Glutamine
Metabolic Dependency Shapes Bivalent Antiviral Response in Host Cells in Response to Poly:IC: The Role of Glutamine Open
The establishment of effective antiviral responses within host cells is intricately related to their metabolic status, shedding light on immunometabolism. In this study, we investigated the hypothesis that cellular reliance on glutamine me…
View article: Comparison of scales for the evaluation of aneurysmal subarachnoid haemorrhage: a retrospective cohort study
Comparison of scales for the evaluation of aneurysmal subarachnoid haemorrhage: a retrospective cohort study Open
View article: Cholesterol transport and beyond: Illuminating the versatile functions of <scp>HDL</scp> apolipoproteins through structural insights and functional implications
Cholesterol transport and beyond: Illuminating the versatile functions of <span>HDL</span> apolipoproteins through structural insights and functional implications Open
High‐density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and inflammation modulation. The proteome of HDL particles is indeed complex and di…
View article: Metabolic disorders exacerbate the formation of glial scar after stroke
Metabolic disorders exacerbate the formation of glial scar after stroke Open
Metabolic disorders are risk factors for stroke exacerbating subsequent complications. Rapidly after brain injury, a glial scar forms, preventing excessive inflammation and limiting axonal regeneration. Despite the growing interest in woun…
View article: A Holistic Approach to Cardiometabolic and Infectious Health in the General Population of Reunion Island: The REUNION Study
A Holistic Approach to Cardiometabolic and Infectious Health in the General Population of Reunion Island: The REUNION Study Open
View article: PCSK9 deficiency promotes the development of peripheral neuropathy
PCSK9 deficiency promotes the development of peripheral neuropathy Open
PCSK9 best-known and studied function is to induce the hepatic degradation of the low-density lipoprotein receptor (LDLR), thereby increasing the concentration of LDL-cholesterol (LDL-C) in the blood. Beyond its effects on LDL, recent stud…
View article: Insulin signaling promotes neurogenesis in the brain of adult zebrafish
Insulin signaling promotes neurogenesis in the brain of adult zebrafish Open
Insulin is a peptide hormone that plays a central role in the regulation of circulating blood glucose in vertebrates, including zebrafish. Increasing evidence has demonstrated the important role of insulin in many brain functions. In zebra…
View article: Metabolic Dependency Shapes Bivalent Antiviral Response in Host Cells in response to poly:IC: The Role of Glutamine
Metabolic Dependency Shapes Bivalent Antiviral Response in Host Cells in response to poly:IC: The Role of Glutamine Open
The establishment of effective antiviral responses within host cells is intricately related to their metabolic status, shedding light on immunometabolism. In this study, we investigated the hypothesis that cellular reliance on glutamine me…
View article: Lipoprotein(a): A Residual Cardiovascular Risk Factor in Statin-Treated Stroke Survivors
Lipoprotein(a): A Residual Cardiovascular Risk Factor in Statin-Treated Stroke Survivors Open
Lp(a) contributes to the residual coronary artery disease risk of statin-treated stroke/TIA survivors, paving the way for use of therapies targeting Lp(a) in this population with stroke. (Lipitor In The Prevention Of Stroke, For Patients W…
View article: HDL anti-inflammatory function is impaired and associated with high SAA1 and low APOA4 levels in aneurysmal subarachnoid hemorrhage
HDL anti-inflammatory function is impaired and associated with high SAA1 and low APOA4 levels in aneurysmal subarachnoid hemorrhage Open
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease with high morbidity and mortality rates. Within 24 hours after aSAH, monocytes are recruited and enter the subarachnoid space, where they mature into macrophages, increasin…
View article: Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles
Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles Open
View article: Computed tomography in the assessment of aneurysmal subarachnoid hemorrhage for functional outcome and delayed cerebral ischemia: a retrospective cohort study.
Computed tomography in the assessment of aneurysmal subarachnoid hemorrhage for functional outcome and delayed cerebral ischemia: a retrospective cohort study. Open
BACKGROUND/OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening event with major complications such as delayed cerebral ischemia (DCI) or acute hydrocephalus and poor neurological outcome. DCI occurs most frequently 7 …
View article: Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study Open
SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoprotein…
View article: Extracellular Vesicles Are Conveyors of the NS1 Toxin during Dengue Virus and Zika Virus Infection
Extracellular Vesicles Are Conveyors of the NS1 Toxin during Dengue Virus and Zika Virus Infection Open
Extracellular vesicles (EVs), produced during viral infections, are of emerging interest in understanding infectious processes and host–pathogen interactions. EVs and exosomes in particular have the natural ability to transport nucleic aci…
View article: Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation
Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation Open
High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentr…
View article: Extracellular Vesicles are Conveyors of the NS1 Toxin during Flavivirus Infection
Extracellular Vesicles are Conveyors of the NS1 Toxin during Flavivirus Infection Open
Extracellular vesicles (EVs), produced during viral infections, are of emerging interest in understanding infectious processes and host-pathogen interactions. EVs and exosomes in particular have the natural ability to transport nucleic aci…
View article: Ayapana triplinervis Vahl: Potential toxicity and therapeutic effects assessed in a zebrafish model
Ayapana triplinervis Vahl: Potential toxicity and therapeutic effects assessed in a zebrafish model Open
Background: : In Reunion, 27 medicinal plants have recently been registered in the French Pharmacopoeia. Among them, Ayapana triplinervis Vahl (A. triplinervis) is traditionally used to combat inflammation and oxidative stress, as well as …