Olivier Peyruchaud
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View article: Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritis
Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritis Open
Autotaxin (ATX) is a lysophospholipase D (lysoPLD) serving as both a lysophosphatidic acid (LPA)-producing enzyme and a LPA docking molecule. ATX binds to the cell surface via interaction with adhesive molecules, including β1-integrin, pot…
View article: Voluntary exercise in mice triggers an anti-osteogenic and pro-tenogenic response in the ankle joint without affecting long bones
Voluntary exercise in mice triggers an anti-osteogenic and pro-tenogenic response in the ankle joint without affecting long bones Open
View article: Curcumin and amaranth as potential anti-inflammatory and protective agents in bone and joint diseases
Curcumin and amaranth as potential anti-inflammatory and protective agents in bone and joint diseases Open
There has been growing interest in medical research focused on natural products. As a result of the ancestral knowledge passed down through generations and the demands of our current era, there has been an increased demand for new strategi…
View article: Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors
Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors Open
View article: Data from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Data from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The αvβ3 integrin is an adhesion recepto…
View article: Supplementary Figure Legends 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Supplementary Figure Legends 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
Supplementary Figure Legends 1-3 from Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
View article: Supplementary Figures 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Supplementary Figures 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
Supplementary Figures 1-3 from Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
View article: Supplementary Figures 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Supplementary Figures 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
Supplementary Figures 1-3 from Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
View article: Data from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Data from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The αvβ3 integrin is an adhesion recepto…
View article: Supplementary Figure Legends 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
Supplementary Figure Legends 1-3 from Tumor α<sub>v</sub>β<sub>3</sub> Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases Open
Supplementary Figure Legends 1-3 from Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases
View article: Circulating autotaxin levels in healthy teenagers: Data from the Vitados cohort
Circulating autotaxin levels in healthy teenagers: Data from the Vitados cohort Open
Autotaxin (ATX) is a secreted enzyme with a lysophospholipase D activity, mainly secreted by adipocytes and widely expressed. Its major function is to convert lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), an essential bio…
View article: Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung
Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung Open
Metastases are the main cause of death in cancer patients, and platelets are largely known for their contribution in cancer progression. However, targeting platelets is highly challenging given their paramount function in hemostasis. Using…
View article: X-Linked Hypophosphatemia, Not Only a Skeletal Disease But Also a Chronic Inflammatory State
X-Linked Hypophosphatemia, Not Only a Skeletal Disease But Also a Chronic Inflammatory State Open
Context X-linked hypophosphatemia (XLH) is a rare genetic disease caused by a primary excess of fibroblast growth factor 23 (FGF23). FGF23 has been associated with inflammation and impaired osteoclastogenesis, but these pathways have not b…
View article: Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis
Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis Open
View article: Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders
Autotaxin/Lysophosphatidic Acid Axis: From Bone Biology to Bone Disorders Open
Lysophosphatidic acid (LPA) is a natural bioactive phospholipid with pleiotropic activities affecting multiple tissues, including bone. LPA exerts its biological functions by binding to G-protein coupled LPA receptors (LPA1-6) to stimulate…
View article: Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells
Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells Open
View article: 922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models
922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models Open
Background Autotaxin (ATX) is a secreted glycoprotein that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA). The expression of both ATX and LPA is elevated in most solid tumors and plasma. LPA signaling directly modu…
View article: Response to Cysteamine in Osteoclasts Obtained from Patients with Nephropathic Cystinosis: A Genotype/Phenotype Correlation
Response to Cysteamine in Osteoclasts Obtained from Patients with Nephropathic Cystinosis: A Genotype/Phenotype Correlation Open
Bone complications of cystinosis have been recently described. The main objectives of this paper were to determine in vitro the impact of CTNS mutations and cysteamine therapy on human osteoclasts and to carry out a genotype-phenotype anal…
View article: POS0404 VOLUNTARY WHEEL RUNNING MODEL IN MICE TO MECHANICALLY STIMULATE THE ENTHESIS OF THE ACHILLES TENDON
POS0404 VOLUNTARY WHEEL RUNNING MODEL IN MICE TO MECHANICALLY STIMULATE THE ENTHESIS OF THE ACHILLES TENDON Open
View article: Tamoxifen Treatment in the Neonatal Period Affects Glucose Homeostasis in Adult Mice in a Sex-Dependent Manner
Tamoxifen Treatment in the Neonatal Period Affects Glucose Homeostasis in Adult Mice in a Sex-Dependent Manner Open
Tamoxifen is a selective estrogen receptor modulator used to activate the CREERT2 recombinase, allowing tissue-specific and temporal control of the somatic mutagenesis to generate transgenic mice. Studies integrating development and metabo…
View article: Emerging role of cysteinyl LTs in cancer
Emerging role of cysteinyl LTs in cancer Open
Cysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these lipid mediators orch…
View article: BMP9, but Not BMP10, Acts as a Quiescence Factor on Tumor Growth, Vessel Normalization and Metastasis in a Mouse Model of Breast Cancer
BMP9, but Not BMP10, Acts as a Quiescence Factor on Tumor Growth, Vessel Normalization and Metastasis in a Mouse Model of Breast Cancer Open
Background: Angiogenesis has become an attractive target for cancer therapy.However, despite the initial success of anti-VEGF (Vascular endothelial growth factor) therapies, the overall survival appears only modestly improved and resistanc…
View article: Bioactive lipids and cancer metastasis to bone
Bioactive lipids and cancer metastasis to bone Open
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, h…
View article: The type 1 lysophosphatidic acid receptor is involved in osteoblastogenesis up to osteocytogenesis
The type 1 lysophosphatidic acid receptor is involved in osteoblastogenesis up to osteocytogenesis Open
International audience
View article: Emerging role of cysteinyl leukotrienes in cancer
Emerging role of cysteinyl leukotrienes in cancer Open
Cysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these lipid mediators orch…
View article: Inhibition of Osteoclast Differentiation by 1.25-D and the Calcimimetic KP2326 Reveals 1.25-D Resistance in Advanced CKD
Inhibition of Osteoclast Differentiation by 1.25-D and the Calcimimetic KP2326 Reveals 1.25-D Resistance in Advanced CKD Open
Active vitamin D analogs and calcimimetics are the main therapies used for treating secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD). Peripheral blood mononuclear cells of 19 pediatric patients with CKD1-5…
View article: Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification
Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification Open
View article: Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell Surface
Autotaxin Implication in Cancer Metastasis and Autoimunne Disorders: Functional Implication of Binding Autotaxin to the Cell Surface Open
Autotaxin (ATX) is an exoenzyme which, due to its unique lysophospholipase D activity, is responsible for the synthesis of lysophosphatidic acid (LPA). ATX activity is responsible for the concentration of LPA in the blood. ATX expression i…
View article: The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice
The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice Open
Breast cancer with bone metastasis is essentially incurable with current anticancer therapies. The bone morphogenetic protein (BMP) pathway is an attractive therapeutic candidate, as it is involved in the bone turnover and in cancer cell f…
View article: Osteoclast‐Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss
Osteoclast‐Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss Open
Objective The severity of rheumatoid arthritis ( RA ) correlates directly with bone erosions arising from osteoclast ( OC ) hyperactivity. Despite the fact that inflammation may be controlled in patients with RA , those in a state of susta…