Olivier Rosnet
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View article: Deciphering the dynamic proteome of multiciliated cells
Deciphering the dynamic proteome of multiciliated cells Open
Multiciliated cells (MCCs) are essential for generating directional fluid flow across specialized epithelia in various vertebrate organs. MCC differentiation involves a unique, tightly regulated program characterized by massive centriole a…
View article: Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer
Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer Open
View article: Dual role of Xenopus Odf2 in multiciliated cell patterning and differentiation
Dual role of Xenopus Odf2 in multiciliated cell patterning and differentiation Open
View article: Inhibition of STAT3/Fanconi anemia axis by Nifuroxazide is synthetic lethal with PARP inhibitor and selectively targets breast cancer stem cells
Inhibition of STAT3/Fanconi anemia axis by Nifuroxazide is synthetic lethal with PARP inhibitor and selectively targets breast cancer stem cells Open
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen…
View article: The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly
The evolutionary conserved proteins CEP90, FOPNL, and OFD1 recruit centriolar distal appendage proteins to initiate their assembly Open
In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface, and docking to the plasma membrane. Basal body docking involves the interaction of both the distal end of …
View article: Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function
Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function Open
Ciliated epithelia perform essential functions in animals across evolution, ranging from locomotion of marine organisms to mucociliary clearance of airways in mammals. These epithelia are composed of multiciliated cells (MCCs) harboring my…
View article: The evolutionary conserved complex CEP90, FOPNL and OFD1 specifies the future location of centriolar distal appendages, and promotes their assembly
The evolutionary conserved complex CEP90, FOPNL and OFD1 specifies the future location of centriolar distal appendages, and promotes their assembly Open
In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface and docking to the plasma membrane. Basal body docking involves the interaction of both the distal end of t…
View article: Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function
Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function Open
Ciliated epithelia perform a variety of essential functions across animal evolution, ranging from locomotion of marine organisms to mucociliary clearance of airways in mammals. These epithelia are composed of multiciliated cells (MCCs) har…
View article: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells Open
View article: Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy
Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy Open
Skeletal dysplasias are a clinically and genetically heterogeneous group of bone and cartilage disorders. A total of 436 skeletal dysplasias are listed in the 2015 revised version of the nosology and classification of genetic skeletal diso…
View article: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells Open
Multiciliated cells (MCCs) harbour dozens to hundreds of motile cilia, which beat in a synchronized and directional manner, thus generating hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation critically …
View article: Fifteen years of research on oral–facial–digital syndromes: from 1 to 16 causal genes
Fifteen years of research on oral–facial–digital syndromes: from 1 to 16 causal genes Open
Oral–facial–digital syndromes (OFDS) gather rare genetic disorders characterised by facial, oral and digital abnormalities associated with a wide range of additional features (polycystic kidney disease, cerebral malformations and several o…
View article: OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome
OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome Open
Oral-facial-digital (OFD) syndromes are rare heterogeneous disorders characterized by the association of abnormalities of the face, the oral cavity and the extremities, some due to mutations in proteins of the transition zone of the primar…
View article: Recruitment of FOR20 and OFD1 onto pericentriolar satellites and centrosomes depends on the formation of a ternary complex with KIAA0753
Recruitment of FOR20 and OFD1 onto pericentriolar satellites and centrosomes depends on the formation of a ternary complex with KIAA0753 Open
Stable microtubules organized on the basis of a nine-fold rotational symmetry constitute the structural basis of centrioles and basal bodies. A number of proteins associate with these structures to drive the process of centrosomes and cili…