Explanipedia

Reply to Guidolin et al. Comment on “Somnin et al. Study of Interactions Between Gadolinium-Based Contrast Agents and Collagen by Taylor Dispersion Analysis and Frontal Analysis Continuous Capillary Electrophoresis. Pharmaceuticals 2024, 17, 1633” Open

Chutintorn Somnin, Joseph Chamieh, Laurent Leclercq, Christelle Medina, Olivier Rousseaux , et al. · 2025

We understand your surprise regarding our data showing a GBCA retention on Amicon® filters [...]

Interaction study between gadolinium-based contrast agents and lysozyme using frontal analysis continuous capillary electrophoresis Open

Chutintorn Somnin, Joseph Chamieh, Laurent Leclercq, Christelle Medina, Olivier Rousseaux , et al. · 2025

[90Y]Y-L4-Lipo/ ethyl esters of Iodized fatty acids of poppy seed oil (lipiodol® ultra-fluid), a new TARE formulation, designed from a lipophilic ligand for stability and safety Open

Olivier Fougère, Anne Dencausse, Nicolas Lepareur, Gaëtan Van Simaeys, Gilles Doumont , et al. · 2025

With good in vitro stability at low activity lasting at least 3 half-lives and a T/NT ratio of 4 in vivo, [⁹⁰Y]Y-L4-Lipo/Lipiodol^® Ultra-Fluid is confirmed as a valid candidate treatment for transarterial radioemboliz…

[90Y]Y-L4-Lipo/ Ethyl esters of iodized fatty acids of poppy seed oil (Lipiodol® Ultra-Fluid), a new TARE formulation, designed from a lipophilic ligand for stability and safety Open

Olivier Fougère, Anne Dencausse, Nicolas Lepareur, Gaëtan Van Simaeys, Gilles Doumont , et al. · 2025

Background: Despite recent therapeutic advances, liver cancer management remains a medico-economic priority for several countries. Patients frequently present at an advanced stage, preventing them from benefiting from salvage surgery. Ther…

Study of Interactions Between Gadolinium-Based Contrast Agents and Collagen by Taylor Dispersion Analysis and Frontal Analysis Continuous Capillary Electrophoresis Open

Chutintorn Somnin, Joseph Chamieh, Laurent Leclercq, Christelle Medina, Olivier Rousseaux , et al. · 2024

Background: Gadolinium-based contrast agents (GBCA) are widely used in magnetic resonance imaging (MRI) to enhance image contrast by interacting with water molecules, thus improving diagnostic capabilities. However, understanding the resid…

Gadopiclenol: A q = 2 Gadolinium-Based MRI Contrast Agent Combining High Stability and Efficacy Open

Ilham Maimouni, Céline Henoumont, Marie-Christine De Goltstein, Jean‐François Mayer, Anissa Dehimi , et al. · 2024

Objectives Gadopiclenol is a q = 2 pyclen gadolinium-based contrast agent (GBCA) recently approved by the Food and Drug Administration, European Medicines Agency, and other European countries. The aim of this report is to demonstrate its s…

Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents Open

Chutintorn Somnin, Laurent Leclercq, Joseph Chamieh, Mael Le Menedeu, Christelle Medina , et al. · 2024

Gadolinium-based contrast agents (GBCA) are complexes of a Gadolinium metal center and a linear or macrocyclic polyamino-carboxylic acid chelating agent. These agents are employed to enhance the visibility of deep abnormalities through MRI…

CCDC 2143077: Experimental Crystal Structure Determination Open

Charlene Harriswangler, Laura Caneda‐Martínez, Olivier Rousseaux, David Esteban‐Gómez, Olivier Fougère , et al. · 2022

CCDC 2143076: Experimental Crystal Structure Determination Open

Charlene Harriswangler, Laura Caneda‐Martínez, Olivier Rousseaux, David Esteban‐Gómez, Olivier Fougère , et al. · 2022

Versatile Macrocyclic Platform for the Complexation of [natY/90Y]Yttrium and Lanthanide Ions Open

Charlene Harriswangler, Laura Caneda‐Martínez, Olivier Rousseaux, David Esteban‐Gómez, Olivier Fougère , et al. · 2022

We report a macrocyclic ligand (H₃L⁶) based on a 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane platform containing three acetate pendant arms and a benzyl group attached to the fourth nitroge…

CCDC 2043994: Experimental Crystal Structure Determination Open

Gwladys Nizou, Enikő Molnár, Nadège Hamon, Ferenc K. Kálmán, Olivier Fougère , et al. · 2021

Pyclen-Based Ligands Bearing Pendant Picolinate Arms for Gadolinium Complexation Open

Gwladys Nizou, Enikő Molnár, Nadège Hamon, Ferenc K. Kalman, Olivier Fougère , et al. · 2020

We report the synthesis of two pyclen-based regioisomer ligands (pyclen = 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca1(15),11,13-triene) functionalized with picolinic acid pendant arms either at positions 3,9-pc2pa (L5) or 3,6-pc2pa (L6) of t…

Pyclen-Based Ligands Bearing Pendant Picolinate Arms for Gadolinium Complexation Open

Gwladys Nizou, Enikő Molnár, Nadège Hamon, Ferenc K. Kalman, Olivier Fougère , et al. · 2020

We report the synthesis of two pyclen-based regioisomer ligands (pyclen = 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca1(15),11,13-triene) functionalized with picolinic acid pendant arms either at positions 3,9-pc2pa (L5) or 3,6-pc2pa (L6) of t…

CCDC 1992262: Experimental Crystal Structure Determination Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

CCDC 1992260: Experimental Crystal Structure Determination Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

CCDC 1992259: Experimental Crystal Structure Determination Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

CCDC 1992261: Experimental Crystal Structure Determination Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

A family of three picolinate pyclen based ligands, previously investigated for the complexation of Y 3+ and some lanthanide ions (Gd 3+ , Eu 3+ ), was studied with 161 Tb and 177 Lu in view of potential radiotherapeutic applications. The s…

Expanding the Scope of Pyclen-Picolinate Lanthanide Chelates to Po-Tential Theranostic Applications Open

Gwladys Nizou, Chiara Favaretto, Francesca Borgna, Pascal V. Grundler, Nathalie Saffon‐Merceron , et al. · 2020

A family of three picolinate pyclen based ligands, previously investigated for the complexation of Y³⁺ and some lanthanide ions (Gd³⁺, Eu³⁺), was studied with ¹⁶¹Tb and ¹⁷⁷Lu in view o…

Physicochemical and Pharmacokinetic Profiles of Gadopiclenol Open

Caroline Robic, Marc Port, Olivier Rousseaux, Stéphanie Louguet, Nathalie Fretellier , et al. · 2019

Objectives We aimed to evaluate gadopiclenol, a newly developed extracellular nonspecific macrocyclic gadolinium-based contrast agent (GBCA) having high relaxivity properties, which was designed to increase lesion detection and characteriz…

CCDC 1586316: Experimental Crystal Structure Determination Open

Mariane Le Fur, Enikő Molnár, Maryline Beyler, Ferenc K. Kálmán, Olivier Fougère , et al. · 2018