Olivier Saurel
YOU?
Author Swipe
View article: PacL-organized membrane-associated effluxosomes coordinate multi-metal resistance in <i>Mycobacterium tuberculosis</i>
PacL-organized membrane-associated effluxosomes coordinate multi-metal resistance in <i>Mycobacterium tuberculosis</i> Open
Metal ion homeostasis is crucial for bacterial pathogens to withstand metal-induced stress during infection. However, the mechanisms underlying bacterial resistance to metal stress remain incompletely understood, particularly how bacteria …
View article: Sodium is a negative allosteric regulator of the ghrelin receptor
Sodium is a negative allosteric regulator of the ghrelin receptor Open
The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment. Among them, sodium ions have been proposed to play a substantial role as endogenous all…
View article: Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms
Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms Open
Transition metals are toxic at high concentrations. The P 1B -ATPase metal exporter CtpC/Rv3270 is required for resistance to zinc poisoning in the human pathogen Mycobacterium tuberculosis . Here, we discovered that zinc resistance also d…
View article: DMSO Solubility Assessment for Fragment-Based Screening
DMSO Solubility Assessment for Fragment-Based Screening Open
In this paper, we report comprehensive experimental and chemoinformatics analyses of the solubility of small organic molecules (“fragments”) in dimethyl sulfoxide (DMSO) in the context of their ability to be tested in screening experiments…
View article: DMSO solubility assessment for fragment-based screening
DMSO solubility assessment for fragment-based screening Open
We report comprehensive experimental and chemoinformatics analysis of solubility of small organic molecules (“fragments”) in dimethyl sulfoxide (DMSO) in the context of their ability to be tested in screening experiments. Here, DMSO solubi…
View article: DMSO solubility assessment for fragment-based screening
DMSO solubility assessment for fragment-based screening Open
We report comprehensive experimental and chemoinformatics analysis of solubility of small organic molecules (“fragments”) in dimethyl sulfoxide (DMSO) in the context of their ability to be tested in screening experiments. Here, DMSO solubi…
View article: Conformational flexibility of coenzyme A and its impact on the post‐translational modification of acyl carrier proteins by 4′‐phosphopantetheinyl transferases
Conformational flexibility of coenzyme A and its impact on the post‐translational modification of acyl carrier proteins by 4′‐phosphopantetheinyl transferases Open
One central question surrounding the biosynthesis of fatty acids and polyketide‐derived natural products is how the 4′‐phosphopantetheinyl transferase (PPTase) interrogates the essential acyl carrier protein (ACP) domain to fulfill the ini…
View article: Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain
Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain Open
Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of sol…
View article: Local and Global Dynamics in <i>Klebsiella pneumoniae</i> Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution
Local and Global Dynamics in <i>Klebsiella pneumoniae</i> Outer Membrane Protein a in Lipid Bilayers Probed at Atomic Resolution Open
The role of membrane proteins in cellular mechanism strongly depends on their dynamics, and solid-state magic-angle spinning (MAS) nuclear magnetic resonance (NMR) is a unique method to exhaustively characterize motions of proteins in a li…
View article: The One-carbon Carrier Methylofuran from Methylobacterium extorquens AM1 Contains a Large Number of α- and γ-Linked Glutamic Acid Residues
The One-carbon Carrier Methylofuran from Methylobacterium extorquens AM1 Contains a Large Number of α- and γ-Linked Glutamic Acid Residues Open
Methylobacterium extorquens AM1 uses dedicated cofactors for one-carbon unit conversion. Based on the sequence identities of enzymes and activity determinations, a methanofuran analog was proposed to be involved in formaldehyde oxidation i…