Explanipedia

Meta-analyses of clozapine, norclozapine levels and their ratio across three genome wide association studies Open

Susanna Maria Rask, Anssi Solismaa, Ari Ahola‐Olli, Espen Molden, Kevin S. O’Connell , et al. · 2025

Recent genome wide association studies (GWAS) found associations between clozapine serum levels and single nucleotide polymorphisms (SNP) in intragenic region between cytochrome P450 1A1 ( CYP1A1 ) and CYP1A2 and nuclear factor 1B ( NFIB )…

Treatment adherence in first-episode psychosis: A one-year follow-up study comparing self-reported adherence, pharmacy refill data, and therapeutic drug monitoring Open

J. Leijala, Olli Kampman, Teemu Gunnar, Jaana Suvisaari · 2025

Medication non-adherence is common in FEP. Pharmacy refill data provided a more accurate adherence measure than self-report. Enhancing adherence requires psychoeducation, follow-up, and proactive monitoring. Measuring drug concentrations a…

IL-8 and IL-1RA serum levels predicting depression treatment response in 6-week follow-up Open

Tuukka Mökkönen, Anssi Solismaa, Mari Hämäläinen, Eeva Moilanen, Olli Kampman · 2025

Objective: This study aims to ascertain the effect of baseline IL-1Ra and IL-8 in the treatment response of patients with major depressive disorder (MDD) and to clarify the relationship between inflammation markers and depression. Methods:…

Suicidal acts and thoughts among persons with psychotic disorders in the Finnish SUPER study Open

Johan Ahti, Willehard Haaki, Willehard Haaki, Jaana Suvisaari, Solja Niemelä , et al. · 2025

Background Psychotic disorders, including schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), psychotic depression (PD), and other nonaffective psychoses (ONAP), are associated with increased risk of suicidal acts. F…

Socioeconomic status, antidepressant use, and return to work after disability due to common mental disorders Open

Helena Leppänen, Olli Kampman, Reija Autio, Antti Tanskanen, Heidi Taipale , et al. · 2025

Background Common mental disorders (CMDs) are significant causes of work disability. Low socioeconomic status (SES) is a known risk factor for CMDs and work disability, one possible reason being poorer treatment adherence. We aimed to stud…

Influence of CYP2D6 phenotype on adherence, adverse effects, and attitudes in aripiprazole and risperidone users Open

Elina Hietala, Anssi Solismaa, Markku Lähteenvuo, Ari Ahola‐Olli, Katja Häkkinen , et al. · 2025

Non-adherence and negative attitudes towards medication are major problems in treating psychotic disorders. Cytochrome P450 2D6 (CYP2D6) contributes to the metabolism of aripiprazole and risperidone, and variations in CYP2D6 activity may a…

Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders Open

Erik Cederlöf, Minna Torniainen‐Holm, Anders Kämpe, Ari Ahola‐Olli, Katri Kantojärvi , et al. · 2025

Background Sleep problems are common in psychotic disorders and are associated with worse quality of life and disease prognosis. Genome-wide association studies (GWAS) have revealed genetic influences for schizophrenia and sleep, but polyg…

General medical comorbidities in psychotic disorders in the Finnish SUPER study Open

Johan Ahti, Tuula Kieseppä, Willehard Haaki, Jaana Suvisaari, Solja Niemelä , et al. · 2024

Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk f…

Leptin and leptin receptor gene polymorphisms and depression treatment response Open

Ida-Maria Tavast, Anssi Solismaa, Leo-Pekka Lyytikäinen, Nina Mononen, Eeva Moilanen , et al. · 2024

Objective: Associations between leptin ( LEP ) and leptin receptor ( LEPR ) gene polymorphisms and mood disorders have been found but not yet confirmed in multiple studies. The aim of our study was to study the associations between LEP and…

Association of obesity to reaction time and visual memory in schizophrenia Open

J.S. Toimela, Anu‐Helmi Halt, Martta Kerkelä, Olli Kampman, Jaana Suvisaari , et al. · 2024

A retrospective analysis of iv ketamine outcome on hospitalisations in an unselected psychiatric sample Open

Karl Sandström, Olli Kampman, Peter Asellus · 2024

Objective: This study aims to explore the outcome with iv ketamine treatment in a real-world clinical setting, primarily measured as posttreatment days hospitalised. Methods: The psychiatric medical records of 46 patients having received i…

Antipsychotic medications and sleep problems in patients with schizophrenia Open

Erik Cederlöf, Minna Torniainen‐Holm, Heidi Taipale, Jari Tiihonen, Antti Tanskanen , et al. · 2024

Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders Open

Anders Kämpe, Jaana Suvisaari, Markku Lähteenvuo, Tarjinder Singh, Ari Ahola‐Olli , et al. · 2024

Association of somatic comorbidity and treatment adherence in patients with psychotic disorder Open

J. Leijala, Olli Kampman, Jaana Suvisaari, Saana Eskelinen · 2024

Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia Open

Ville Mäkipelto, Annamari Tuulio‐Henriksson, Christian Hakulinen, Solja Niemelä, Markku Lähteenvuo , et al. · 2024

Influence of Cyp2d6 Phenotype on Adherence, Adverse Effects, and Attitudes Towards Antipsychotic Treatment in Aripiprazole and Risperidone Users Open

Elina Hietala, Anssi Solismaa, Markku Lähteenvuo, Ari Ahola‐Olli, Katja Häkkinen , et al. · 2024

Predictors of short-term response and the role of heavy alcohol use in treatment of depression Open

Kaisa Luoto, Antero Lassila, Esa Leìnonen, Olli Kampman · 2023

Machine Learning Classification of Psychiatric Data Associated with Compensation Claims for Patient Injuries Open

Martti Juhola, Tommi Nikkanen, Juho Niemi, Maiju Welling, Olli Kampman · 2023

Background Adverse events are common in health care. In psychiatric treatment, compensation claims for patient injuries appear to be less common than in other medical specialties. The most common types of patient injury claims in psychiatr…

Socioeconomic status, psychotherapy duration, and return to work from disability due to common mental disorders Open

Helena Leppänen, Olli Kampman, Reija Autio, Tino Karolaakso, P Rissanen , et al. · 2023

Objective Low socioeconomic status (SES) is a risk factor for work disability due to common mental disorders (CMDs), one possible reason being inequal use of services. Psychotherapy is an evidence-based treatment for CMDs. This stud…

Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity Open

Kimmo Suokas, Olli Kurkela, Jaakko Nevalainen, Jaana Suvisaari, Christian Hakulinen , et al. · 2023

Purpose In Finland, prevalence of schizophrenia is higher in the eastern and northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores. Both genetic and environmental factors have been hypothesized to cont…

The impact of rare protein coding genetic variation on adult cognitive function Open

Chia‐Yen Chen, Ruoyu Tian, Tian Ge, Max Lam, Gabriela Sánchez-Andrade , et al. · 2023

Compelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact cognitive function in the adult population ( n…

Geographical variation in treated psychotic and other mental disorders in Finland by region and urbanicity Open

Kimmo Suokas, Olli Kurkela, Jaakko Nevalainen, Jaana Suvisaari, Christian Hakulinen , et al. · 2023

Background In Finland, prevalence of schizophrenia is higher in the eastern and northern regions and co-occurs with the distribution of schizophrenia polygenic risk scores. Both genetic and environmental factors have been hypothesized to c…

Cohort profile: SUPER-Finland – the Finnish study for hereditary mechanisms of psychotic disorders Open

Markku Lähteenvuo, Ari Ahola‐Olli, Kimmo Suokas, Minna Torniainen‐Holm, Zuzanna Misiewicz , et al. · 2023

Purpose SUPER-Finland is a large Finnish collection of psychosis cases. This cohort also represents the Finnish contribution to the Stanley Global Neuropsychiatric Genetics Initiative, which seeks to diversify genetic sample collection to …

Functional Characterization of Six <i>SLCO1B1</i> (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder Open

Katja Häkkinen, Wilma Kiander, Heidi Kidron, Markku Lähteenvuo, Lea Urpa , et al. · 2023

Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose…

The effect of nuclear factor 1B polymorphisms and valproate use on clozapine metabolism Open

Susanna Maria Rask, Anssi Solismaa, Ari Ahola‐Olli, Leo‐Pekka Lyytikäinen, Nina Mononen , et al. · 2023

Substance Use and Sleep Problems in Patients With Psychotic Disorders Open

Erik Cederlöf, Minna Torniainen‐Holm, Johan Ahti, Markku Lähteenvuo, Jarmo Hietala , et al. · 2022

Background Substance use and sleep problems are common in patients with psychotic disorders, but their associations in these patients have not been evaluated. We aimed to investigate associations between substance use and sleep problems in…

Mortality in persons with recent primary or secondary care contacts for mental disorders in Finland Open

Kimmo Suokas, Christian Hakulinen, Reijo Sund, Olli Kampman, Sami Pirkola · 2022

Excess mortality among persons with mental disorders has been consistently documented1, 2, but the mortality risk over a full spectrum of mental disorders treated both in primary and secondary care remains to be explored at a nationwide le…

Functional characterization of six <i>SLCO1B1</i> (OATP1B1) variants observed in Finnish individuals with a psychotic disorder Open

Katja Häkkinen, Wilma Kiander, Heidi Kidron, Markku Lähteenvuo, Lea Urpa , et al. · 2022

Aim Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose pa…

Socioeconomic factors and use of psychotherapy in common mental disorders predisposing to disability pension Open

Helena Leppänen, Olli Kampman, Reija Autio, Tino Karolaakso, Turkka Näppilä , et al. · 2022

Differences in psychosocial functioning between psychotic disorders in the Finnish SUPER study Open

Johan Ahti, Tuula Kieseppä, Jaana Suvisaari, Kimmo Suokas, Minna Torniainen‐Holm , et al. · 2022

Level of functioning and psychosocial outcomes differed markedly between psychotic disorders, particularly in independent living. Outcomes were worst for schizophrenia and best for BD. Across all psychotic disorders, female gender and life…

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