Per Eriksson
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View article: Tricuspid Aortic Valve Regurgitation Associates With Ascending Aortic Aneurysm Through Endothelial Activation and Lipoprotein Infiltration
Tricuspid Aortic Valve Regurgitation Associates With Ascending Aortic Aneurysm Through Endothelial Activation and Lipoprotein Infiltration Open
BACKGROUND: An abnormal accumulation of immune cells and inflammation has been described in ascending aortic aneurysm, but the factor driving disease initiation remains elusive. Interestingly, ascending aortic dilatation often occurs along…
View article: The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis
The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis Open
Objective Despite recent advances, the pathophysiological mechanisms underlying anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) remain incompletely understood, and comparative proteomic analyses of AAV subtypes ar…
View article: Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland Open
View article: Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities
Plasma proteomic and metabolomic profiling of coronary and carotid atherosclerosis in the SCAPIS study—differences and similarities Open
Funding Agencies|European Research Council [ERC-STG-2018-801965]; Swedish Research Council [VR 2019-01471, 2019-01236]; Swedish Heart-Lung Foundation [Hjart-Lungfonden] [20190505, 20200173]; Swedish Government [ALFGBG-991828]; Swedish coun…
View article: Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes
Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes Open
Red blood cells (RBCs) induce endothelial dysfunction in type 2 diabetes (T2D), but the mechanism by which RBCs communicate with the endothelium is unknown. This study tested the hypothesis that extracellular vesicles (EVs) secreted by RBC…
View article: In‐Depth Analysis of Disease Manifestations in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides Identifies Distinct Clinical Phenotypes
In‐Depth Analysis of Disease Manifestations in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides Identifies Distinct Clinical Phenotypes Open
Objective The antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ invo…
View article: Enhancing Cardiovascular Risk Prediction with a Simplified Carotid IMT Protocol: Evidence from the IMPROVE Study
Enhancing Cardiovascular Risk Prediction with a Simplified Carotid IMT Protocol: Evidence from the IMPROVE Study Open
Background/Objectives: Carotid intima-media thickness (CIMT) has long been used as an index of subclinical atherosclerosis, but its role as a risk modifier in cardiovascular (CV) risk optimization has recently been questioned due to method…
View article: Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve
Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve Open
Bicuspid aortic valve (BAV), a prevalent congenital cardiac defect, predisposes patients to severe complications. Despite its high heritability, previously identified protein-coding and common regulatory mutations account for only a small …
View article: Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis
Blood cytokines in major depressive disorder in drug-naïve adolescents: A systematic review and meta-analysis Open
TNF-α was significantly elevated in drug-naïve adolescents with MDD. To further understand the role of TNF-α in MDD, a thorough investigation is required, taking into account the diversity, subtypes, chronicity, and severity of MDD.
View article: Statin‐associated regulation of hepatic <i>PNPLA3</i> in patients without known liver disease
Statin‐associated regulation of hepatic <i>PNPLA3</i> in patients without known liver disease Open
Background and objectives Statins are used for metabolic dysfunction‐associated steatotic liver disease (MASLD) (NAFLD) treatment, but their role in this context is unclear. Genetic variants of patatin‐like phospholipase domain containing …
View article: A functional genomic framework to elucidate novel causal metabolic dysfunction–associated fatty liver disease genes
A functional genomic framework to elucidate novel causal metabolic dysfunction–associated fatty liver disease genes Open
Background and Aims: Metabolic dysfunction–associated fatty liver disease (MASLD) is the most prevalent chronic liver pathology in western countries, with serious public health consequences. Efforts to identify causal genes for MASLD have …
View article: Lipoprotein retention and inflammation due to regurgitant blood flow as part of the natural history of degenerative ascending aortic aneurysms
Lipoprotein retention and inflammation due to regurgitant blood flow as part of the natural history of degenerative ascending aortic aneurysms Open
BACKGROUND An abnormal accumulation of immune cells and a disrupted lipoprotein metabolism has previously been described as part of the pathogenesis of ascending aortic aneurysm in patients with tricuspid aortic valves. The factor driving …
View article: An endothelial regulatory module links blood pressure regulation with elite athletic performance
An endothelial regulatory module links blood pressure regulation with elite athletic performance Open
The control of transcription is crucial for homeostasis in mammals. A previous selective sweep analysis of horse racing performance revealed a 19.6 kb candidate regulatory region 50 kb downstream of the Endothelin3 ( EDN3 ) gene. Here, the…
View article: Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1
Red blood cell-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through a mechanism involving arginase 1 Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Foundation for Geriatric Diseases Karolinska Institutet (2023-01860). Swedish Heart and Lung Foundation (20220210) Background The mechanisms driving the …
View article: Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data
Determinants of Carotid Wall Echolucency in a Cohort of European High Cardiovascular Risk Subjects: A Cross-Sectional Analysis of IMPROVE Baseline Data Open
Echolucency, a measure of plaque instability associated with increased cardiovascular risk, can be assessed in both the carotid plaque and the plaque-free common carotid intima–media (IM) complex as a gray-scale median (plaque-GSM and IM-G…
View article: Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult Open
Apolipoprotein-B (APOB)-containing lipoproteins cause atherosclerosis. Whether the vasculature is the initially responding site or if atherogenic dyslipidemia affects other organs simultaneously is unknown. Here we show that the liver resp…
View article: Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study
Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study Open
Objectives The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). Design and setting A prospec…
View article: Ascending Aortic Aneurysm in Relation to Aortic Valve Phenotype
Ascending Aortic Aneurysm in Relation to Aortic Valve Phenotype Open
Being born with a bicuspid aortic valve (BAV) is a significant risk factor for developing an ascending aortic aneurysm (AscAA). Research has uncovered different mechanisms influencing AscAA development in BAV-patients compared to those wit…
View article: A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes
A functional genomic framework to elucidate novel causal non-alcoholic fatty liver disease genes Open
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver pathology in western countries, with serious public health consequences. Efforts to identify causal genes for NAFLD have been hampered by the r…
View article: Interaction Between Subclinical Carotid Atherosclerosis Endotype and Biological Sex: A Study From Improve Cohort
Interaction Between Subclinical Carotid Atherosclerosis Endotype and Biological Sex: A Study From Improve Cohort Open
View article: The Natural History of Ascending Aortic Aneurysms Involve Infiltration of Lipoproteins and Immune Cells
The Natural History of Ascending Aortic Aneurysms Involve Infiltration of Lipoproteins and Immune Cells Open
View article: Hemodynamics and plasma biomarkers in individuals with mild-to-moderate ascending aortic dilatation and tricuspid aortic valves
Hemodynamics and plasma biomarkers in individuals with mild-to-moderate ascending aortic dilatation and tricuspid aortic valves Open
Background Ascending aortic (AA) dilatation is a silent disease that requires frequent follow-up measurements of the AA diameter. Unfortunately, the AA diameter is an insufficient predictor of future growth and complications. Hemodynamic a…
View article: Erythrocyte-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through arginase 1
Erythrocyte-derived extracellular vesicles from type 2 diabetes patients induce endothelial dysfunction through arginase 1 Open
Background The mechanisms driving the development of cardiovascular injury in type 2 diabetes (T2D) remain incompletely understood. We recently demonstrated that red blood cells (RBCs) from patients with T2D (T2D-RBCs) act as mediators of …
View article: The Natural History of Ascending Aortic Aneurysms Involves a Site-Specific Infiltration of Lipoproteins and Immune Cells
The Natural History of Ascending Aortic Aneurysms Involves a Site-Specific Infiltration of Lipoproteins and Immune Cells Open
Background Aortic valve regurgitation (AR) is associated with degeneration of the ascending aortic media and, opposed to aortic stenosis (AS), associates with ascending aortic aneurysm (AscAA). AscAA is characterized by immune cell infiltr…
View article: SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm?
SPP1/osteopontin: a driver of fibrosis and inflammation in degenerative ascending aortic aneurysm? Open
View article: Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases Open
View article: Bicuspid aortic valve aortopathy is characterized by embryonic endothelial to mesenchymal transition and endothelial instability
Bicuspid aortic valve aortopathy is characterized by embryonic endothelial to mesenchymal transition and endothelial instability Open
View article: A machine learning based approach to identify carotid subclinical atherosclerosis endotypes
A machine learning based approach to identify carotid subclinical atherosclerosis endotypes Open
Aims To define endotypes of carotid subclinical atherosclerosis. Methods and results We integrated demographic, clinical, and molecular data (n = 124) with ultrasonographic carotid measurements from study participants in the IMPROVE cohort…
View article: Novel Association of the NOTCH Pathway Regulator <i>MIB1</i> Gene With the Development of Bicuspid Aortic Valve
Novel Association of the NOTCH Pathway Regulator <i>MIB1</i> Gene With the Development of Bicuspid Aortic Valve Open
Importance Nonsyndromic bicuspid aortic valve (nsBAV) is the most common congenital heart valve malformation. BAV has a heritable component, yet only a few causative genes have been identified; understanding BAV genetics is a key point in …
View article: The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms
The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms Open
Endothelial cells respond to mechanical forces exerted by blood flow. Endothelial cell–cell junctions and the sites of endothelial adhesion to the matrix sense and transmit mechanical forces to the cellular cytoskeleton. Here we show that …