Heather Olson
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View article: Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors
Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors Open
This study demonstrates that INS, IGF-1, and IGF-2 regulate Rho GTPase and MRTFA activation, thereby contributing to the control of actin cytoskeletal dynamics in neuronal cells. Given the role of INS and IGFs in neuronal survival and neur…
View article: Untargeted GC-MS Metabolic Profiling of Anaerobic Gut Fungi Reveals Putative Terpenoids and Strain-Specific Metabolites
Untargeted GC-MS Metabolic Profiling of Anaerobic Gut Fungi Reveals Putative Terpenoids and Strain-Specific Metabolites Open
Background/Objectives: Anaerobic gut fungi (Neocallimastigomycota) are biotechnologically relevant, lignocellulose-degrading microbes with under-explored biosynthetic potential for secondary metabolites. Untargeted metabolomic profiling wi…
View article: Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism
Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism Open
Syntrophic microbial consortia can contribute significantly to the activity and function of anoxic ecosystems, yet are often too rare to study their in situ physiologies using traditional molecular methods. Here, we combined bioorthogonal …
View article: Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors
Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors Open
Background Given the role of metabolism in brain health and disease, investigating the role of insulin (INS) and insulin-like growth factors (IGFs) as potential therapeutic strategies for neurodegenerative diseases is currently underway. Y…
View article: A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia
A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia Open
Lung tissue is composed of various functional units, each essential for maintaining the intricate functions of the lung. Disruptions in the molecular and cellular mechanisms in the lung can cause tissue fibrosis, inflammation, and severe b…
View article: Sex differences in story recall decline in preclinical Alzheimer's disease
Sex differences in story recall decline in preclinical Alzheimer's disease Open
Stage II pre-clinical Alzheimer's disease is defined by the presence of increased amyloid-beta evidenced by fluid and/or imaging biomarkers, in the absence of clinical signs and symptoms. Previous research suggests that pre-clinical sex di…
View article: The relationship between right and left hemisphere regional tau and proper name recall from Logical Memory story recall
The relationship between right and left hemisphere regional tau and proper name recall from Logical Memory story recall Open
Background Sensitive screening for early Alzheimer’s disease (AD)‐related cognitive decline are needed. Prior research links high beta‐amyloid (Aβ) levels to reduced proper name (PN) retrieval in individuals without cognitive impairment. W…
View article: The relationship between right and left hemisphere regional tau and proper name recall from Logical Memory story recall
The relationship between right and left hemisphere regional tau and proper name recall from Logical Memory story recall Open
Background Sensitive screening for early Alzheimer’s disease (AD)‐related cognitive decline are needed. Prior research links high beta‐amyloid (Aß) levels to reduced proper name (PN) retrieval in individuals without cognitive impairment. W…
View article: O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis
O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic pulmonary disease that is characterized by an excessive accumulation of extracellular matrix (ECM) proteins (e.g. collagens) in the parenchyma, which ultimately leads to respirato…