Olumide Ogunbiyi
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Spatial transcriptomic analysis of muscle biopsy from patients with treatment-naive juvenile dermatomyositis reveals mitochondrial abnormalities despite disease-related interferon-driven signature Open
This study highlights mitochondrial dysfunction as a consistent pathological feature in JDM muscle, which may be independent of interferon-driven inflammation. These findings highlight the potential for mitochondrial-targeted therapies in …
View article: Supplementary Figure S5 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S5 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 5 Features of the GBM_CBM and GBM_MES_ATYP subgroups
View article: Supplementary Figure S6 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S6 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 6 Multivariate analyses within the TYA cohort.
View article: Supplementary Table S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 2 Copy number analysis. Gene amplifications derived from methylation array analysis for the TYA cohort with associated frequencies.
View article: Supplementary Table S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 4 Sequencing data analysis. Mutations in Cancer Census Genes identified in TYA HGG cases from available whole exome sequencing data (n=107).
View article: Supplementary Figure S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S4 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 4 Mutations in TYA gliomas
View article: Supplementary Figure S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S2 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 2 DNA Methylation profiling of the TYA HGG cohort.
View article: Supplementary Table S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 3 Copy number analysis. Gene deletions derived from methylation array analysis for the TYA cohort with associated frequencies.
View article: Supplementary Figure S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 1 A, Bar plot showing the frequency of age distribution across the TYA cohort, and the gender proportions. Blue representing male, pink representing female. B, Pie chart representing the original diagnoses of the TYA c…
View article: Supplementary Figure S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Figure S3 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary figure 3 DNA copy number profiling of the TYA cohort.
View article: Supplementary Table S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Supplementary Table S1 from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Supplementary Table 1 Sample cohort. Clinicopathological and molecular profiling data of the TYA HGG cohort (n=207).
View article: Data from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
Data from The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Purpose:High-grade gliomas (HGG) occur in any central nervous system location and at any age. HGGs in teenagers/young adults (TYA) are understudied. This project aimed to characterize these tumors to support accurate stratification of pati…
Spatial transcriptomic analysis of muscle biopsy from treatment-naive juvenile dermatomyositis patients reveals mitochondrial abnormalities despite disease-related interferon driven signature Open
Objectives This study aimed to investigate the spatial transcriptomic landscape of muscle tissue from treatment-naïve juvenile dermatomyositis (JDM) patients in comparison to healthy paediatric muscle tissue. Methods Muscle biopsies from t…
View article: Characterizing the Human Fetal Perimeiotic 45,X Ovary at Single-Cell Resolution
Characterizing the Human Fetal Perimeiotic 45,X Ovary at Single-Cell Resolution Open
Context Turner syndrome (TS) is the most common genetic cause of premature (primary) ovarian insufficiency (POI). Human fetal 45,X ovaries demonstrate marked apoptosis by 15 to 20 weeks post conception (wpc), likely partly driven by X-chro…
View article: Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer
Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer Open
Multiple Endocrine Neoplasia Type 2 (MEN2) is an autosomal dominant disease caused by pathogenic variants in the receptor tyrosine kinase RET, with strong genotype-phenotype correlations. The development and progression of these tumours ar…
View article: The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations
The Spectrum of IDH- and H3-Wildtype High-Grade Glioma Subgroups Occurring across Teenage and Young Adult Patient Populations Open
Purpose: High-grade gliomas (HGG) occur in any central nervous system location and at any age. HGGs in teenagers/young adults (TYA) are understudied. This project aimed to characterize these tumors to support accurate stratification of pat…
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Data from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary methods and figures
View article: Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma
Supplementary Video from Short-wave infrared imaging enables high-contrast fluorescence-guided surgery in neuroblastoma Open
Supplementary video showing fluorescence-guided resection of a subcutaneous model of Neuroblastoma injected with anti-GD2 fluorescence probes
Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids Open
Faithful genetically engineered in vivo models of medulloblastoma (MB) are currently available only for some molecular subgroups, in keeping with recent studies showing the unique role of human-specific progenitors in the development of G3…