Olusola Ajibaye
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View article: Prevalence and effects of placental anemia on birthweight and neonatal health in Nigeria
Prevalence and effects of placental anemia on birthweight and neonatal health in Nigeria Open
Background: Placental anemia (PlAn) relates to a deficiency in red blood cells or hemoglobin in the placenta, an indicator of maternal anemia impacting maternal and fetal health. Objective: This study aimed to determine the prevalence of P…
View article: Prevalence of Malaria Among Febrile Patients in Oluyoro Hospital, Ibadan, Oyo State
Prevalence of Malaria Among Febrile Patients in Oluyoro Hospital, Ibadan, Oyo State Open
Malaria remains a major public health burden in sub-Saharan Africa, with Nigeria accounting for a significant proportion of global cases. This cross-sectional study was conducted at Oluyoro Catholic Hospital, Ibadan, between November 2023 …
View article: Correction: Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial
Correction: Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial Open
View article: Molecular Surveillance of malaria in Nigeria reveals expansion of chloroquine-sensitive infections
Molecular Surveillance of malaria in Nigeria reveals expansion of chloroquine-sensitive infections Open
Background The success of malaria elimination in sub-Saharan Africa rests largely on the sustained efficacies of the control and prevention chemo-interventions used in malaria treatment and chemoprophylaxis in the highest-burden countries.…
View article: Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial
Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial Open
View article: Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples
Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples Open
We describe the Pf8 data resource, the latest MalariaGEN release of curated genome variation data on over 33,000 Plasmodium falciparum samples from 99 partner studies and 122 locations over more than 50 years. This release provides open a…
View article: Predictive Value of Salivary Cortisol for Pre-Event Anxiety in Elite University Athletes
Predictive Value of Salivary Cortisol for Pre-Event Anxiety in Elite University Athletes Open
This study investigated the predictive value of salivary cortisol for pre-event anxiety among elite athletes in three contact sports, to inform effective personalized psychological interventions tailored to sport and gender. Twenty-four el…
View article: The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery
The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery Open
New chemical entities are constantly being investigated towards antimalarial drug discovery, and they require animal models for toxicity and efficacy testing. Murine models show physiological similarities to humans and are therefore indisp…
View article: The Importance of Murine Models and Their Resultant In Vivo Pharmacokinetics, Safety, and Efficacy Assessments for Antimalarial Drug Discovery
The Importance of Murine Models and Their Resultant In Vivo Pharmacokinetics, Safety, and Efficacy Assessments for Antimalarial Drug Discovery Open
New chemical entities are consistently being investigated in antimalarial drug discovery and they require animal models for toxicity and efficacy testing. Murine models in searching for novel antimalarial drugs are inevitable because they …
View article: Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study
Prevalence and factors associated with childhood malaria and anaemia in Osun state, Nigeria: a baseline household malariometric study Open
View article: Evaluation of three rapigen biocredit point-of-care tests for malaria case management in Lagos, Nigeria
Evaluation of three rapigen biocredit point-of-care tests for malaria case management in Lagos, Nigeria Open
Introduction: Histidine-rich protein 2 (HRP2) antigen kits are widely used for malaria diagnosis in tropical regions due to their heat stability. The Plasmodium Lactate Dehydrogenase (pLDH) used in BIOCREDIT® malaria test kit is claimed to…
View article: Safety and Immunogenicity of Fractional Doses of COVID-19 Vaccines among Nigerian Adults- A Randomised Non-Inferiority trial
Safety and Immunogenicity of Fractional Doses of COVID-19 Vaccines among Nigerian Adults- A Randomised Non-Inferiority trial Open
The shortage of COVID-19 vaccines posed a significant challenge in optimal response to the COVID-19 pandemic. Fractional doses of vaccine with adequate immunogenic response and proven safety profile emerged as potential strategy to extend …
View article: Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria
Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria Open
Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum ( Pf )-infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status an…
View article: Sub-microscopic Plasmodium falciparum infections and multiple drug resistant single nucleotide polymorphic alleles in pregnant women from southwestern Nigeria
Sub-microscopic Plasmodium falciparum infections and multiple drug resistant single nucleotide polymorphic alleles in pregnant women from southwestern Nigeria Open
Objectives The study evaluated sub-microscopic malaria infections in pregnancy using two malaria Rapid Diagnostic Tests (mRDTs), microscopy and RT-PCR and characterized Plasmodium falciparum dihydrofolate reductase ( Pf dhfr) and Plasmodiu…
View article: Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria
Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria Open
Background Routine surveillance for antimalarial drug resistance is critical to sustaining the efficacy of artemisinin-based Combination Therapies (ACTs). Plasmodium falciparum kelch-13 (Pfkelch-13) and non- Pfkelch-13 artemisinin ( ART) r…
View article: Acute and Subacute Oral Toxicity Characterization and Safety Assessment of COVID Organics® (Madagascar’s Anti-COVID Herbal Tea) in Animal Models
Acute and Subacute Oral Toxicity Characterization and Safety Assessment of COVID Organics® (Madagascar’s Anti-COVID Herbal Tea) in Animal Models Open
Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. No drug has been generally approved as safe and effective for the treatment of COVID-19. Several therapeu…
View article: Contemporary Anti-Retroviral Drugs (ARVDs) Disrupt Follicular Development in Female Wistar Rats
Contemporary Anti-Retroviral Drugs (ARVDs) Disrupt Follicular Development in Female Wistar Rats Open
The study demonstrated a disruption in the reproductive hormones of female Wistar rats receiving anti-retroviral regimens containing EFV. Clinical studies are required to determine if these changes are seen in women receiving EFV-based tre…
View article: A survey of chloroquine use for prevention and treatment of COVID-19 in Nigeria
A survey of chloroquine use for prevention and treatment of COVID-19 in Nigeria Open
Background: Rampant chloroquine/hydroxychloroquine poisoning in Nigerian hospitals following suggestions of its possible efficacy in the treatment and prevention of the newly emerged COVID-19 disease informed this survey.
Objectives: The …
View article: Baseline prevalence of molecular marker of sulfadoxine/pyrimethamine resistance in Ebonyi and Osun states, Nigeria: amplicon deep sequencing of<i>dhps</i>-540
Baseline prevalence of molecular marker of sulfadoxine/pyrimethamine resistance in Ebonyi and Osun states, Nigeria: amplicon deep sequencing of<i>dhps</i>-540 Open
Background Chemoprevention plays an important role in malaria control strategy. Perennial malaria chemoprevention (PMC) using sulfadoxine/pyrimethamine (SP) is a WHO-approved strategy to combat malaria in young children and may lead to dru…
View article: Efficacy and safety of Tenofovir-based regimen in elderly people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis
Efficacy and safety of Tenofovir-based regimen in elderly people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis Open
Objective The study examined whether the benefit and adverse effects of the tenofovir-based highly active antiretroviral therapy (HAART) regimen outweigh the non-tenofovir-based regimen in the elderly population. Methods We searched PubMed…
View article: Tumor Necrosis Factor Receptor II Gene Polymorphism and Association with Plasmodium falciparum Malaria in Badagry, Lagos, Nigeria
Tumor Necrosis Factor Receptor II Gene Polymorphism and Association with Plasmodium falciparum Malaria in Badagry, Lagos, Nigeria Open
Host genetic factors, host-parasite interactions, parasite genetic diversity, and/or environmental influences have been implicated in the molecular basis of susceptibility and resistance to Plasmodium parasite infections. Host Tumor Necros…
View article: In vivo antiplasmodial potential of Thaumatococcus danielli extracts (Benth.) against Plasmodium berghei
In vivo antiplasmodial potential of Thaumatococcus danielli extracts (Benth.) against Plasmodium berghei Open
Elimination of malaria infection with available antimalarial drugs is threatened by resistance developed by Plasmodium species and requires alternative drugs. Thaumatococcus danielli leaves are traditionally used in some local communities …
View article: First Line Anti-Retroviral (ARV) Drugs Disrupt Follicular Development in Female Wistar Rats
First Line Anti-Retroviral (ARV) Drugs Disrupt Follicular Development in Female Wistar Rats Open
INTRODUCTION: There are genuine concerns that long-term use of antiretroviral drugs may be associated with reproductive complications in females. This study aimed to ascertain the effect of highly active antiretroviral drugs on the ovarian…
View article: Plasmodium falciparum Merozoite Surface Protein 2 Genetic Diversity and Multiplicity of Infection in Asymptomatic Malaria Cases in Lagos, Nigeria
Plasmodium falciparum Merozoite Surface Protein 2 Genetic Diversity and Multiplicity of Infection in Asymptomatic Malaria Cases in Lagos, Nigeria Open
Background: The burden of malaria due to Plasmodium falciparum is high in Nigeria. Continuous surveillance of the genetic diversity of malaria parasites can provide important information on transmission intensity in an area. Objective: Thi…
View article: Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria
Outcome of Symptom-Based RT-PCR Testing for SARS-CoV-2: Experience from a Large Public Testing Centre in Nigeria Open
Background: Access to testing for SARS-CoV-2 in Nigeria is still highly restricted. Only patients who are symptomatic for SARS-CoV-2 are selected for testing. This pattern of testing will miss a large proportion of individuals with the inf…
View article: SARS-CoV-2 sequencing collaboration in west Africa shows best practices
SARS-CoV-2 sequencing collaboration in west Africa shows best practices Open
Genomic surveillance can track pathogen transmission during an outbreak, identifying actionable genomic variation on the co-evolution of pathogens with the human genome and socioeconomic demographics.1Meredith LW Hamilton WL Warne B et al.…
View article: Malaria interventions and control programes in Sub-Saharan Africa: A narrative review
Malaria interventions and control programes in Sub-Saharan Africa: A narrative review Open
Malaria transmission and prevalence involves a triangular web of interactions between man, vector, and the environment. Any meaningful effort in malaria control, elimination and or eradication should target weakening and or breaking the fo…
View article: The –250G>A polymorphism in the hepatic lipase gene promoter influences plasma lipid profile and lipoprotein ratio in patients with ischemic stroke
The –250G>A polymorphism in the hepatic lipase gene promoter influences plasma lipid profile and lipoprotein ratio in patients with ischemic stroke Open
Objective: To evaluate the influence of –250G>A (rs2070895) polymorphism in hepatic lipase gene (LIPC) promoter on plasma lipid parameters of ischemic stroke patients. Methods: A total of 100 stroke patients and 100 control subjects matche…
View article: Pro- and anti-inflammatory response profile modulates Plasmodium falciparum malaria outcomes among subjects from Baiyeku, Ikorodu, Lagos, Nigeria.
Pro- and anti-inflammatory response profile modulates Plasmodium falciparum malaria outcomes among subjects from Baiyeku, Ikorodu, Lagos, Nigeria. Open
Background Available evidence indicates that the various stages of the malaria parasite life cycle elicit specific immune responses of which the relative levels of pro-inflammatory cytokines are key to disease progression, killing the para…
View article: Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria
Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria Open